Results 51 to 60 of about 4,293 (152)
Magnetic Resonance in Chemistry, Volume 64, Issue 12, Page 1013-1019, December 2026.The impact of temperature on the analysis of STD NMR ligand epitope mapping has been thoroughly investigated. For protein–ligand complexes under fast exchange kinetics, a negligible temperature effect is observed. For the intermediate exchange regime, VT‐STD NMR allows to obtain better discriminated epitope mappings, hence enabling the accurate ...
Gabriel Rocha +3 more
wiley +1 more source
Frontiers in ImmunologyAberrant glycosylation patterns of glycoproteins and glycolipids have long been recognized as one the major hallmarks of cancer cells that has led to numerous glycoconjugate vaccine attempts.
René Roy
doaj +1 more source
Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V
Nature Communications, 2018 The activity of glycosyltransferase GnT-V correlates with cancer malignancy and poor prognosis but its mechanism of action is poorly understood. Here, the authors solve crystal structures of free and substrate analog-bound GnT-V, providing insights into ...
Masamichi Nagae +8 more
doaj +1 more source
, 2021 Glycan-Protein interactions in pathological processes: development of new molecular and cellular models for glycobiology-oriented studiesGlycan-Protein interactions in pathological processes: development of new molecular and cellular models for ...
PAIARDI, GIULIA
core
Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu +2 more
wiley +1 more source
Decoding the Role of Glycans in Malaria
Frontiers in Microbiology, 2017 Complications arising from malaria are a concern for public health authorities worldwide, since the annual caseload in humans usually exceeds millions. Of more than 160 species of Plasmodium, only 4 infect humans, with the most severe cases ascribed to ...
Pollyanna S. Gomes +4 more
doaj +1 more source
Global functions of O-glycosylation:promises and challenges in O-glycobiology
, 2021 Mucin type O-glycosylation is one of the most diverse types of glycosylation, playing essential roles in tissue development and homeostasis. In complex organisms, O-GalNAc glycans comprise a substantial proportion of the glycocalyx, with defined ...
Mathias A. I. Nielsen +9 more
core +1 more source
Structural glycobiology in the age of electron cryo-microscopy [PDF]
, 2020 The methodology underpinning the construction, refinement, validation and analysis of atomic models of glycoproteins and protein-carbohydrate complexes has received a long-overdue boost in the last five years.
Haroldas Bagdonas +5 more
core +1 more source
Bacterial sialidases subvert the complement system through desialylation
Protein Science, Volume 35, Issue 11, November 2026.Abstract Bacterial sialidases (neuraminidases) are widely studied virulence factors, yet their impact on the complement system, a central component of innate immunity, remains poorly understood. Here, we investigate the effects of six sialidases from five human pathogens, including Bacteroides fragilis, Clostridium perfringens, Tannerella forsythia ...
Kurni Kurniyati +6 more
wiley +1 more source
Veterinary SciencesToxoplasmosis is a relevant parasitic infection in sheep, with ovine meat an important source of human exposure. Accurate detection of the early immune response to Toxoplasma gondii is essential for preventing reproductive losses and improving diagnostic
Patrícia Oliveira Meira-Santos +9 more
doaj +1 more source