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The Endothelial Glycocalyx: A Possible Therapeutic Target in Cardiovascular Disorders
Frontiers in Cardiovascular Medicine, 2022 The physiological, anti-inflammatory, and anti-coagulant properties of endothelial cells (ECs) rely on a complex carbohydrate-rich layer covering the luminal surface of ECs, called the glycocalyx.
Anastasia Milusev +3 more
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The endothelial glycocalyx—All the same? No, it is not
Acute Medicine & Surgery, 2023 The endothelial glycocalyx covers the lumen of blood vessels throughout the body and plays an important role in endothelial homeostasis. Advances in electron microscopy techniques have provided clues to better understand the structure and composition of ...
Kodai Suzuki +2 more
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Endothelial glycocalyx in different flow regions of the trabecular outflow pathway in bovine eyes [PDF]
Frontiers in Cell and Developmental BiologyBackgroundGlycocalyx is a hair-like structure covering the endothelium of the aqueous outflow pathway. While trabecular outflow is segmental circumferentially around the eye, regional differences in glycocalyx morphology remain largely unexplored.
Hoi-Lam Li +5 more
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Sex differences in endothelial glycocalyx thickness and the response to glycocalyx‐targeted therapy among older adults [PDF]
Physiological ReportsEndothelial glycocalyx thickness declines with age, potentially increasing cardiovascular disease risk. However, sex differences in glycocalyx thickness and responses to glycocalyx‐targeted therapies remain unclear.
Colin J. Gimblet +3 more
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Protective Effects of Hydrogen-Rich Saline Against Hemorrhagic Shock in Rats via an Endothelial Glycocalyx Pathway [PDF]
BiomedicinesBackground/Objective: The endothelial glycocalyx is a gel-like layer on the vascular endothelial surface that is crucial for maintaining vascular homeostasis.
Aya Kimura +7 more
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Heliyon, 2023 Glycocalyx is located outside the vascular endothelial cells playing an important role in vascular homeostasis. However, lacking efficient detection methods is one of the biggest obstacles to study the glycocalyx. In this study, three dehydration methods
Zhi Li +3 more
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Mechanotransduction and the glycocalyx [PDF]
Journal of Internal Medicine, 2006 Abstract.Endothelial cells (ECs) line all blood vessel walls and are exposed to the mechanical forces of blood flow which modulate their function and play a role in vascular regulation, remodelling and disease. The principal mechanical forces sensed by ECs are the shear stress of flowing blood on their apical surface, and the circumferential stress ...
M. Y. Pahakis, John M. Tarbell
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Biophysical Journal, 2013 Glycocalyx is a highly charged layer of membrane-bound biological macromolecules attached to a cell membrane. This layer functions as a barrier between a cell and its surrounding. Glycocalyx also serves as a mediator for cell-cell interactions and protects a cell membrane from the direct action of physical forces and stresses allowing the membrane to ...
Reinis Danne +4 more
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Glycocalyx in Endotoxemia and Sepsis [PDF]
The American Journal of Pathology, 2020 Along with the recognition of a crucial role played by endothelial dysfunction secondarily igniting cardiovascular, pulmonary, and renal complications, investigational focus has extended toward endothelial glycocalyx. This delicate coating of cells, including the vascular endothelium, regulates permeability, leukocyte traffic, nitric oxide production ...
Michael S. Goligorsky, Dong Sun
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Endothelial glycocalyx degradation during sepsis: Causes and consequences
Matrix Biology Plus, 2021 The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the vascular lumen. It is enriched in proteoglycans, which are proteins attached to the glycosaminoglycans heparan sulfate, chondroitin sulfate, dermatan sulfate ...
Ryan C. Sullivan +3 more
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