Results 101 to 110 of about 43,679 (304)

Factors influencing glycocalyx degradation: a narrative review

Frontiers in Immunology
The glycocalyx is a layer of villus-like structure covering the luminal surface of vascular endothelial cells. Damage to the glycocalyx has been proven linked to the development of many diseases. However, the factors that promote damage to the glycocalyx
Jing Wang, Lan Ma, Yu Fang, Tengteng Ye, Hongbo Li, Peng Lan   +5 more
doaj   +1 more source

Pro-atherosclerotic disturbed flow disrupts caveolin-1 expression, localization, and function via glycocalyx degradation

Journal of Translational Medicine, 2018
Background Endothelial-dependent atherosclerosis develops in a non-random pattern in regions of vessel bending and bifurcations, where blood flow exhibits disturbed flow (DF) patterns.
Ian C. Harding, Ronodeep Mitra, Solomon A. Mensah, Ira M. Herman, Eno E. Ebong   +4 more
doaj   +1 more source

The effect of perturbations of the glycocalyx on microvascular perfusion in the obese trauma population: an in vitro study

Trauma Surgery & Acute Care Open, 2021
Objectives Patients with morbid obesity have impaired responses to resuscitation following severe injury, which may contribute to adverse outcomes.
David Edelman, Lawrence N Diebel, Alexander Liviu Marinica, David Liberati   +3 more
doaj   +1 more source

Glycocalyx-induced formation of membrane tubes. [PDF]

Biophys J
Xiao K, Rangamani P.
europepmc   +2 more sources

Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome

JCI Insight, 2021
Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure yet has few pharmacologic therapies, reflecting the mechanistic heterogeneity of lung injury.
A. Rizzo, S. Haeger, K. Oshima, Yimu Yang, A. Wallbank, Ying Jin, M. Lettau, Lynda A Mccaig, N. Wickersham, J. McNeil, I. Zakharevich, S. McMurtry, Christophe J. Langouët-Astrié, K. Kopf, D. Voelker, K. Hansen, C. Shaver, V. Kerchberger, R. Peterson, W. Kuebler, M. Ochs, R. Veldhuizen, Bradford J. Smith, L. Ware, J. Bastarache, E. Schmidt   +25 more
semanticscholar   +1 more source

Shear Conditioning Promotes Microvascular Endothelial Barrier Resilience in a Human BBB‐on‐a‐Chip Model of Systemic Inflammation Leading to Astrogliosis

Advanced Science, EarlyView.
Physiological flow (0.5 Pa) conditioning promotes resilience of an iPSC‐derived blood–brain barrier endothelium to mild systemic inflammation. In contrast, high “cytokine storm” levels induce barrier breakdown, fibrinogen leakage, and astrocyte activation, reconstituting the two‐hit injury mechanism on‐a‐chip.
Kaihua Chen, Isabelle M. Linares, Michelle A. Trempel, Alexis M. Feidler, Dinindu De Silva, Sami Farajollahi, Jordan Jones, Julia Kuebel, Pelin Kasap, Britta Engelhardt, Jonathan Flax, Vinay V. Abhyankar, Richard E. Waugh, Harris A. Gelbard, Niccolo Terrando, James L. McGrath   +15 more
wiley   +1 more source

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease

Nature
The blood–brain barrier (BBB) is highly specialized to protect the brain from harmful circulating factors in the blood and maintain brain homeostasis1,2.
Sophia M. Shi, Ryan J Suh, D. J. Shon, Francisco J. García, Josephine K Buff, Micaiah Atkins, Lulin Li, Nannan Lu, Bryan Sun, Jian Luo, Ning-Sum To, Tom H. Cheung, M. W. Mcnerney, Myriam Heiman, Carolyn R. Bertozzi, Tony Wyss-Coray   +15 more
semanticscholar   +1 more source

Sialic acids regulate microvessel permeability, revealed by novel in vivo studies of endothelial glycocalyx structure and function [PDF]

, 2017
The endothelial glycocalyx forms a continuous coat over the luminal surface of all vessels, and regulates multiple vascular functions. The contribution of individual components of the endothelial glycocalyx to one critical vascular function ...
Aamelfot, Adamson, Adamson, Adamson, Adamson, Adembri, Arkill, Bai, Baldwin, Barker, Bates, Bates, Bingaman, Born, Cai, Cassidy, Chappell, Cioffi, Cuniberti, Curry, Curry, Curry, Curry, Curry, Curry, Curry, Damiano, Dekan, Florian, Fu, Fu, Gao, Gelberg, Geyer, Gorog, Gretz, Haraldsson, Haraldsson, Hu, Huxley, Huxley, Jeansson, Jeansson, Jeansson, Kendall, Kumagai, Lee, Levick, Mason, Michel, Michel, Michel, Nassimizadeh, Oltean, Pahakis, Peti-Peterdi, Pries, Sakarya, Salmon, Salmon, Salmon, Schindelin, Singh, Squire, Tarbell, Tarbell, Tarbell, Tatsuzuki, Vargas, Varki, Weinbaum, Weinbaum, Yen, Zeng   +73 more
core   +3 more sources

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Advanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song   +11 more
wiley   +1 more source

Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The endothelial glycocalyx is a vasoprotective barrier between the blood and endothelium. We hypothesized that glycocalyx degradation is present in preeclampsia, a pregnancy‐specific hypertensive disorder characterized by endothelial ...
Tracey L. Weissgerber, Oscar Garcia‐Valencia, Natasa M. Milic, Elizabeth Codsi, Hajrunisa Cubro, Meryl C. Nath, Wendy M. White, Karl A. Nath, Vesna D. Garovic   +8 more
doaj   +1 more source