Results 111 to 120 of about 6,575 (136)

Glycocalyx shedding as a clinical biomarker in critical illness

Experimental and Molecular Pathology
The endothelial glycocalyx, a carbohydrate-rich layer lining the vascular endothelium, plays a critical role in maintaining vascular homeostasis by regulating permeability, leukocyte adhesion, and inflammatory signaling.
Ayako Inoda, Keiko Suzuki, Hiroyuki Tomita, Hideshi Okada   +3 more
doaj   +1 more source

Antifouling Glycocalyx-Mimetic Peptoids

, 2016
The glycocalyx of the cell is composed of highly hydrated saccharidic groups conjugated to protein and lipid cores. Although components of the glycocalyx are important in cell–cell interactions and other specific biological recognition events, a ...
Sung Hyun Park (521290), Phillip B. Messersmith (765789), Hyun Ok Ham (1917103), Josh W. Kurutz (1917100), Igal G. Szleifer (1917106)   +4 more
core   +1 more source

In vivo glycocalyx assessment in aneurysmal subarachnoid hemorrhage patients: protocol for a prospective observational feasibility study

Pilot and Feasibility Studies
Background Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) is a severe complication linked to prolonged hospitalization, reduced functional outcomes, and increased mortality.
Hanna Schenck, Inger de Ridder, Erik Gommer, Werner Mess, Govert Hoogland, Onno Teernstra, Jim Dings, Sander van Kuijk, Yasin Temel, Roel Haeren   +9 more
doaj   +1 more source

Sex differences in endothelial glycocalyx thickness and the response to glycocalyx‐targeted therapy among older adults

Physiological Reports
Endothelial glycocalyx thickness declines with age, potentially increasing cardiovascular disease risk. However, sex differences in glycocalyx thickness and responses to glycocalyx‐targeted therapies remain unclear.
Colin J. Gimblet, Anthony J. Donato, Diana I. Jalal, Gary L. Pierce   +3 more
doaj   +1 more source

Glomerular endothelial glycocalyx constitutes a barrier to protein permeability

, 2007
Glycocalyx, composed of glycoproteins including proteoglycans, coats the luminal surface of the glomerular capillaries. Human heparanase degrades heparan sulphate glycosaminoglycans and is upregulated in proteinuric states.
Satchell, SC, Peter W. Mathieson, Neal, Chris R., Satchell, Simon C., Tooke, John E., McKenzie, EA, Mckenzie, Eddie, John E. Tooke, McKenzie, Edward A., Simon C. Satchell, Chris R. Neal, Mathieson, Peter W., Anurag Singh, Singh, A, Neal, CR, Tooke, JE, Mathieson, PW, Singh, Anurag, Edward A. McKenzie   +18 more
core   +1 more source

High salt intake and HIV infection on endothelial glycocalyx shedding in salt-sensitive hypertension

Frontiers in Cell and Developmental Biology
The endothelial glycocalyx is closely associated with various physiological and pathophysiological events. Significant modification of the endothelial glycocalyx is an early process in the pathogenesis of cardiovascular disease. High dietary salt and HIV
Sepiso K. Masenga, Sepiso K. Masenga, Situmbeko Liweleya, Annet Kirabo, Annet Kirabo, Annet Kirabo, Annet Kirabo   +6 more
doaj   +1 more source

Porphyromonas gingivalis-derived outer membrane vesicles promote vascular endothelial glycocalyx injury via the PPAD/CitH3/B3GAT1 pathway

Journal of Nanobiotechnology
Background The glycocalyx serves as the skeletal structure of the outer layer of endothelial cells and regulates the function of endothelial cells. Porphyromonas gingivalis (P. gingivalis) outer membrane vesicles (OMVs) exhibit the fundamental biological
Shoucheng Yin, Qihui Qiao, Zhaorong Li, Lijie Lu, Muzhou Jiang, Hanyu Gao, Ziming Ge, Chen Li, Yaping Pan, Li Lin   +9 more
doaj   +1 more source

The native glycocalyx ultrastructure in humans and sponges is a self-assembled, lamellar micro- and nanoarray

Communications Biology
Mucin, proteoglycan, glyconectin, and hyaluronan intermolecular binding in the physiological hydrated state forms the native glycocalyx ultrastructure via the polyvalent interactions of their similar bottle-brush morphologies.
Emanuela Garbarino, Guruprakash Subbiahdoss, Andrea Scheberl, Erik Reimhult, Gradimir Misevic   +4 more
doaj   +1 more source

The Blood-Brain Barrier Glycocalyx

The blood-brain barrier (BBB) is a specialized set of features unique to the central nervous system vasculature that tightly regulates the movement of ions, molecules, and cells between the blood and the brain, maintaining neural homeostasis.
Larsen, Reid
core  

The Endothelial Glycocalyx: Composition, Functions, and Visualization [PDF]

Pflugers Archiv European Journal of Physiology, 2007
This review aims at presenting state-of-the-art knowledge on the composition and functions of the endothelial glycocalyx. The endothelial glycocalyx is a network of membrane-bound proteoglycans and glycoproteins, covering the endothelium luminally.
Mirjam Oude Egbrink, Marc A M J van Zandvoort, Hans Vink   +2 more
exaly   +2 more sources