Results 11 to 20 of about 43,679 (304)

Glycocalyx Impairment in Vascular Disease: Focus on Inflammation [PDF]

Frontiers in Cell and Developmental Biology, 2021
The glycocalyx is a complex polysaccharide-protein layer lining the lumen of vascular endothelial cells. Changes in the structure and function of the glycocalyx promote an inflammatory response in blood vessels and play an important role in the ...
Jing Qu, Yue Cheng, Wenchao Wu, Lixing Yuan, Xiaojing Liu, Xiaojing Liu   +5 more
doaj   +2 more sources

The glycocalyx: a novel diagnostic and therapeutic target in sepsis

Critical Care, 2019
The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It is comprised of membrane-attached proteoglycans, glycosaminoglycan chains, glycoproteins, and adherent plasma proteins. The glycocalyx maintains homeostasis
Ryo Uchimido, Eric P. Schmidt, Nathan I. Shapiro   +2 more
doaj   +2 more sources

The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation

Frontiers in Cell and Developmental Biology, 2020
All cells in the human body are covered by a dense layer of sugars and the proteins and lipids to which they are attached, collectively termed the “glycocalyx.” For decades, the organization of the glycocalyx and its interplay with the cellular state ...
Leonhard Möckl
doaj   +2 more sources

The glycocalyx as a permeability barrier: basic science and clinical evidence

Critical Care, 2022
Preclinical studies in animals and human clinical trials question whether the endothelial glycocalyx layer is a clinically important permeability barrier. Glycocalyx breakdown products in plasma mostly originate from 99.6–99.8% of the endothelial surface
Randal O. Dull, Robert G. Hahn
doaj   +2 more sources

Derangement of the endothelial glycocalyx in sepsis [PDF]

Journal of Thrombosis and Haemostasis, 2019
The vascular endothelial surface is coated by the glycocalyx, a ubiquitous gel-like layer composed of a membrane-binding domain that contains proteoglycans, glycosaminoglycan side-chains, and plasma proteins such as albumin and antithrombin. The endothelial glycocalyx plays a critical role in maintaining vascular homeostasis. However, this component is
T. Iba, J.H. Levy
openaire   +4 more sources

Basal endothelial glycocalyx’s response to shear stress: a review of structure, function, and clinical implications

Frontiers in Cell and Developmental Biology
The endothelial glycocalyx encompasses the entire endothelial cell, transducing extracellular signals and regulating vascular permeability and barrier functions. The apical glycocalyx, which forms the lumen of the vessel, and the basal glycocalyx, at the
Zoe Vittum, Samantha Cocchiaro, Solomon A. Mensah, Solomon A. Mensah   +3 more
doaj   +2 more sources

Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: from the viewpoint of surviving sepsis campaign guidelines

Annals of Intensive Care
Maintaining tissue perfusion in sepsis depends on vascular integrity provided by the endothelial glycocalyx, the critical layer covering the luminal surface of blood vessels. The glycocalyx is composed of proteoglycans, glycosaminoglycans, and functional
Toshiaki Iba, Cheryl L. Maier, Julie Helms, Ricard Ferrer, Jecko Thachil, Jerrold H. Levy   +5 more
doaj   +2 more sources

Salmonella Degrades the Host Glycocalyx Leading to Altered Infection and Glycan Remodeling. [PDF]

, 2016
Complex glycans cover the gut epithelial surface to protect the cell from the environment. Invasive pathogens must breach the glycan layer before initiating infection.
Arabyan, Narine, Desai, Prerak, Foutouhi, Soraya, Huang, Bihua C, Jeannotte, Richard, Kong, Nguyet, Lebrilla, Carlito B, Park, Dayoung, Shah, Jigna, Weimer, Bart C, Weis, Allison M, Williams, Cynthia C   +11 more
core   +3 more sources

Studying the Endothelial Glycocalyx in vitro: What Is Missing? [PDF]

Frontiers in Cardiovascular Medicine, 2021
All human cells are coated by a surface layer of proteoglycans, glycosaminoglycans (GAGs) and plasma proteins, called the glycocalyx. The glycocalyx transmits shear stress to the cytoskeleton of endothelial cells, maintains a selective permeability ...
Andrew B. Haymet, Andrew B. Haymet, Nicole Bartnikowski, Nicole Bartnikowski, Emily S. Wood, Emily S. Wood, Michael P. Vallely, Angela McBride, Angela McBride, Sophie Yacoub, Sophie Yacoub, Scott B. Biering, Eva Harris, Jacky Y. Suen, Jacky Y. Suen, John F. Fraser, John F. Fraser   +16 more
doaj   +2 more sources

The glycocalyx affects the mechanotransductive perception of the topographical microenvironment

Journal of Nanobiotechnology, 2022
The cell/microenvironment interface is the starting point of integrin-mediated mechanotransduction, but many details of mechanotransductive signal integration remain elusive due to the complexity of the involved (extra)cellular structures, such as the ...
Matteo Chighizola, Tania Dini, Stefania Marcotti, Mirko D’Urso, Claudio Piazzoni, Francesca Borghi, Anita Previdi, Laura Ceriani, Claudia Folliero, Brian Stramer, Cristina Lenardi, Paolo Milani, Alessandro Podestà, Carsten Schulte   +13 more
doaj   +2 more sources