Results 21 to 30 of about 43,679 (304)

Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis

Respiratory Research, 2022
Highlights It is the first time to prove the confirm the endothelial glycocalyx impairment in COPD. FGF10 attenuates the development of emphysema and the shedding of glycocalyx induced by CSE in vivo.
Tian Jiang, Weiping Hu, Shaoyuan Zhang, Changhao Ren, Siyun Lin, Zhenyu Zhou, Hao Wu, Jun Yin, Lijie Tan   +8 more
doaj   +2 more sources

Endothelial glycocalyx damage in kidney disease correlates with uraemic toxins and endothelial dysfunction

BMC Nephrology, 2021
Background Damage to the endothelial glycocalyx is an early indicator of vascular damage and a potential marker of endothelial dysfunction. This study aimed to assess the relationship between markers of glycocalyx damage, endothelial dysfunction, and ...
Hui Liew, Matthew A. Roberts, Alun Pope, Lawrence P. McMahon   +3 more
doaj   +2 more sources

The Structure and Function of the Glycocalyx and Its Connection With Blood-Brain Barrier

Frontiers in Cellular Neuroscience, 2021
The vascular endothelial glycocalyx is a dense, bush-like structure that is synthesized and secreted by endothelial cells and evenly distributed on the surface of vascular endothelial cells.
Jing Jin, Fuquan Fang, Wei Gao, Hanjian Chen, Jiali Wen, Xuehua Wen, Junfa Chen   +6 more
doaj   +2 more sources

Recombinant thrombomodulin and recombinant antithrombin attenuate pulmonary endothelial glycocalyx degradation and neutrophil extracellular trap formation in ventilator-induced lung injury in the context of endotoxemia

Respiratory Research
Background Vascular endothelial damage is involved in the development and exacerbation of ventilator-induced lung injury (VILI). Pulmonary endothelial glycocalyx and neutrophil extracellular traps (NETs) are endothelial protective and damaging factors ...
Kenichiro Kikuchi, Satoshi Kazuma, Michiaki Yamakage   +2 more
doaj   +2 more sources

Sulodexide improves vascular permeability via glycocalyx remodelling in endothelial cells during sepsis

Frontiers in Immunology, 2023
Background Degradation of the endothelial glycocalyx is critical for sepsis-associated lung injury and pulmonary vascular permeability. We investigated whether sulodexide, a precursor for the synthesis of glycosaminoglycans, plays a biological role in ...
J. Ying, Caiyan Zhang, Yaodong Wang, Tingyan Liu, Zhenhao Yu, Kexin Wang, Weiming Chen, Yufeng Zhou, Guoping Lu   +8 more
semanticscholar   +1 more source

Evaluation of Endothelial Glycocalyx Damage in Neonatal Lambs With Diarrhoea: A Biomarker-Based Approach. [PDF]

Vet Med Sci
Neonatal lambs with diarrhoea showed increased nitric oxide and decreased heparan sulphate and angiopoietin‐2 levels, suggesting preserved endothelial glycocalyx integrity. Elevated ADAM15 levels in E. coli cases indicate a pathogen‐specific endothelial response, highlighting nitric oxide's potential protective role during inflammation.
Durgut MK, Ok M, Ider M, Tras B, Naseri A, Parlak TM, Alhallaq A, Iyigun SS.   +7 more
europepmc   +2 more sources

The role of the alveolar epithelial glycocalyx in acute respiratory distress syndrome.

American Journal of Physiology - Cell Physiology, 2023
The alveolar epithelial glycocalyx is a dense anionic layer of glycosaminoglycans (GAGs) and proteoglycans that lines the apical surface of the alveolar epithelium.
A. Rizzo, E. Schmidt
semanticscholar   +1 more source

THE GLYCOCALYX AND TRAUMA [PDF]

Shock, 2016
In the United States trauma is the leading cause of mortality among those under the age of 45, claiming approximately 192,000 lives each year. Significant personal disability, lost productivity, and long-term healthcare needs are common and contribute 580 billion dollars in economic impact each year.
Chignalia, Andreia Z., Yetimakman, Feliz, Christiaans, Sarah C., Unal, Sule, Bayrakci, Benan, Wagener, Brant M., Russell, Robert T., Kerby, Jeffrey D., Pittet, Jean-Francois, Dull, Randal O.   +9 more
openaire   +4 more sources

Endothelial Glycocalyx in Retina, Hyperglycemia, and Diabetic Retinopathy.

American Journal of Physiology - Cell Physiology, 2023
The endothelial glycocalyx (EG) is a mesh-like network present on the apical surface of the endothelium. Membrane-bound proteoglycans, the major backbone molecules of the endothelial glycocalyx, consist of glycosaminoglycans attached to core proteins. In
G. Kaur, Norman R. Harris
semanticscholar   +1 more source

An IGFBP7hi endothelial cell subset drives T cell extravasation in psoriasis via endothelial glycocalyx degradation

Journal of Clinical Investigation, 2023
Dysfunction of vascular endothelial cells (ECs) facilitates imbalanced immune responses and tissue hyperinflammation. However, the heterogeneous functions of skin ECs and their underlying mechanism in dermatoses remain to be determined. Here, focusing on
Qingyang Li, S. Shao, Zhenlai Zhu, Jiaoling Chen, Junfeng Hao, Yaxing Bai, Bing Li, E. Dang, G. Wang   +8 more
semanticscholar   +1 more source