Results 31 to 40 of about 43,679 (304)

Sirtuin 1 and endothelial glycocalyx [PDF]

Pflügers Archiv - European Journal of Physiology, 2020
AbstractSirtuin1 deficiency or reduced activity comprises one of the hallmarks of diseases as diverse as chronic cardiovascular, renal, and metabolic, some malignancies, and infections, as well as aging-associated diseases. In a mouse model of endothelium-limited defect in sirtuin 1 deacetylase activity, we found a dramatic reduction in the volume of ...
Lipphardt, Mark, Song, Jong Wook, Goligorsky, Michael S, Lipphardt, Mark; Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, Göttingen, Germany, Song, Jong Wook; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea, Goligorsky, Michael S; Renal Research Institute, New York Medical College at the Touro University, Valhalla, USA   +5 more
openaire   +6 more sources

Glycocalyx–Sodium Interaction in Vascular Endothelium

Nutrients, 2023
The glycocalyx generally covers almost all cellular surfaces, where it participates in mediating cell-surface interactions with the extracellular matrix as well as with intracellular signaling molecules. The endothelial glycocalyx that covers the luminal
L. F. Sembajwe, Abdul M Ssekandi, A. Namaganda, H. Muwonge, J. Kasolo, R. Kalyesubula, A. Nakimuli, Mwesigwa Naome, K. Patel, S. Masenga, Annet Kirabo   +10 more
semanticscholar   +1 more source

The glycocalyx of the sperm surface [PDF]

Human Reproduction Update, 1999
The surface of mammalian spermatozoa is covered by a dense coating of carbohydrate-rich molecules forming a 20-60 nm thick glycocalyx. The majority of sugar residues are attached to proteins which are either integrated within the sperm membrane, or are more or less loosely associated with it.
McArdle, WL, Schroter, S, Osterhof, C, Ivell, R   +3 more
openaire   +3 more sources

Endothelial Damage and the Microcirculation in Critical Illness

Biomedicines, 2022
Endothelial integrity maintains microcirculatory flow and tissue oxygen delivery. The endothelial glycocalyx is involved in cell signalling, coagulation and inflammation.
Rachael Cusack, Marc Leone, Alejandro H. Rodriguez, Ignacio Martin-Loeches   +3 more
doaj   +1 more source

The Endothelial Glycocalyx and Neonatal Sepsis

International Journal of Molecular Sciences, 2022
Sepsis carries a substantial risk of morbidity and mortality in newborns, especially preterm-born neonates. Endothelial glycocalyx (eGC) is a carbohydrate-rich layer lining the vascular endothelium, with important vascular barrier function and cell adhesion properties, serving also as a mechano-sensor for blood flow.
Ahlam Fatmi, Wiam Saadi, Jesús Beltrán-García, José Luis García-Giménez, Federico V. Pallardó   +4 more
openaire   +4 more sources

Endothelial Glycocalyx Degradation in Critical Illness and Injury

Frontiers in Medicine, 2022
The endothelial glycocalyx is a gel-like layer on the luminal side of blood vessels that is composed of glycosaminoglycans and the proteins that tether them to the plasma membrane.
E. Patterson, G. Cepinskas, D. Fraser
semanticscholar   +1 more source

The Endothelial Glycocalyx and Retinal Hemodynamics

Pathophysiology, 2022
Purpose. Previous studies suggest that the endothelial glycocalyx adds to vascular resistance, inhibits thrombosis, and is critical for regulating homogeneous blood flow and ensuring uniform red blood cell (RBC) distribution. However, these functions and consequences of the glycocalyx have not been examined in the retina.
Gaganpreet Kaur, Wendy Leskova, Norman R. Harris   +2 more
openaire   +3 more sources

Cell‐specific targeting of extracellular vesicles through engineering the glycocalyx

Journal of Extracellular Vesicles, 2022
Extracellular vesicles (EVs) are promising carriers for the delivery of a variety of chemical and biological drugs. However, their efficacy is limited by the lack of cellular specificity.
Wenyi Zheng, Rui He, Xiuming Liang, Samantha Roudi, Jeremy P Bost, P. Coly, G. Niel, S. E. Andaloussi   +7 more
semanticscholar   +1 more source

Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-κB/HPSE1 Signaling Pathway During Inflammation

Frontiers in Pharmacology, 2022
Tetramethylpyrazine (TMP), a Chinese traditional herbal extraction widely used in treating cardiovascular diseases, could attenuate vascular endothelial injuries, but the underlying mechanism remains incomprehensive.
Jin Lei, Jin Lei, Peng Xiang, Peng Xiang, Shengmei Zeng, Shengmei Zeng, Le Chen, Le Chen, Lei Zhang, Lei Zhang, Zhiyi Yuan, Zhiyi Yuan, Jun Zhang, Jun Zhang, Tingting Wang, Tingting Wang, Ruihong Yu, Ruihong Yu, Wanping Zhang, Wanping Zhang, Issa Issoufou Ibrahim, Issa Issoufou Ibrahim, Limei Ma, Limei Ma, Chao Yu, Chao Yu   +25 more
doaj   +1 more source

Initial interaction of citrate-coated iron oxide nanoparticles with the glycocalyx of THP-1 monocytes assessed by real-time magnetic particle spectroscopy and electron microscopy [PDF]

, 2020
Interaction with biological material can alter physicochemical parameters of magnetic nanoparticles and might thereby change their magnetic behavior with potentially important implications for various nanoparticle applications.
Ludwig, Antje, Löwa, Norbert, Münster-Wandowski, Agnieszka, Poller, Wolfram C., Schleicher, Moritz, Stangl, Verena, Taupitz, Matthias, Wiekhorst, Frank   +7 more
core   +1 more source