Results 61 to 70 of about 7,626 (185)

Development of novel O-polysaccharide based glycoconjugates for immunization against glanders

Frontiers in Cellular and Infection Microbiology, 2012
Burkholderia mallei, the etiologic agent of glanders, causes severe disease in humans and animals and is a potential agent of biological warfare and terrorism. Diagnosis and treatment of glanders can be challenging, and in the absence of chemotherapeutic
Mary N Burtnick, Christian eHeiss, A. Michele eSchuler, Parastoo eAzadi, Paul J Brett   +4 more
doaj   +1 more source

Genome‐scale insights into metabolic streamlining and photosynthetic energy balance in the extremophile green alga Picocystis salinarum (Picocystophyceae, Chlorophyta)

Journal of Phycology, EarlyView.
Abstract Picocystis salinarum is an early‐diverging chlorophyte and the sole described member of the Picocystophyceae, frequently dominating hypersaline and alkaline lakes despite extreme physicochemical constraints. To elucidate the genomic foundations of its ecological success, we generated a fully annotated, chromosome‐scale nuclear genome assembly ...
Claude Lemieux, Christian Otis, Monique Turmel   +2 more
wiley   +1 more source

Understanding exosomes: A history of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), including exosomes, have emerged as fundamental regulators of cell‐to‐cell communication and are increasingly recognized for their therapeutic and diagnostic promise. While EV research has expanded remarkably over the past two decades, the discipline is rooted in a much longer history of observations ...
Richard J. Miron, Paras Ahmad, Anton Sculean   +2 more
wiley   +1 more source

Predicting cardiovascular disease in peritoneal dialysis patients using glycated proteomics and machine learning: A prospective multicentre study

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Graphical Headlights 1. Glycated proteomics identified candidate cardiovascular biomarkers in peritoneal dialysis patients. 2. A machine learning model integrated two glycated peptides with six clinical indicators. 3. The model achieved ROC‐AUCs of 0.781 in the internal testing set and 0.822 in multicentre external validation.
Ji Ji, Zhaoying Nie, Na Jiang, Ting Xie, Lei Zhang, Xiaoyan Liu, Min Lu, Bo Xiang, Weiwei Wu, Xiaotian Jiang, Lin Zhang, Jun Ji, Jianzhou Zou, Xiaoqiang Ding, Haojie Lu, Xiaofang Yu   +15 more
wiley   +1 more source

Identification of a Glycosylation‐Related Gene Prognostic Signature for Non–Small Cell Lung Cancer

The Journal of Gene Medicine, Volume 28, Issue 11, November 2026.
A ten‐glycosylation‐related‐gene (GRG) prognostic signature for non‐small cell lung cancer (NSCLC) was constructed using TCGA data. Differentially expressed GRGs were screened and refined by Cox and LASSO regression. The ten‐gene signature (including ADAMTS15, PCSK9, MUC2, and B3GNT3) stratified patients into high‐ and low‐risk groups with distinct ...
Qingtao Zhao, Xiaopeng Zhang, Guochen Duan   +2 more
wiley   +1 more source

Preclinical validation of an Escherichia coli O-antigen glycoconjugate for the prevention of serotype O1 invasive disease

Microbiology Spectrum
A US collection of invasive Escherichia coli serotype O1 bloodstream infection (BSI) isolates were assessed for genotypic and phenotypic diversity as the basis for designing a broadly protective O-antigen vaccine.
Laurent Chorro, Duston Ndreu, Axay Patel, Srinivas Kodali, Zhenghui Li, David Keeney, Kaushik Dutta, Aniruddha Sasmal, Arthur Illenberger, C. Lynn Torres, Rosalind Pan, Natalie C. Silmon de Monerri, Ling Chu, Raphael Simon, Annaliesa S. Anderson, Robert G. K. Donald   +15 more
doaj   +1 more source

Bacterial sialidases subvert the complement system through desialylation

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Bacterial sialidases (neuraminidases) are widely studied virulence factors, yet their impact on the complement system, a central component of innate immunity, remains poorly understood. Here, we investigate the effects of six sialidases from five human pathogens, including Bacteroides fragilis, Clostridium perfringens, Tannerella forsythia ...
Kurni Kurniyati, Nicholas D. Clark, Qin Fu, Sheng Zhang, Weigang Qiu, Michael G. Malkowski, Chunhao Li   +6 more
wiley   +1 more source

The Role of Glycoconjugates in Development of Floor Plate During Early Morphogenesis in Mouse Embryo [PDF]

Journal of Kerman University of Medical Sciences, 2004
The floor plate is a small group of cells located at the ventral midline of neural tube. During early neurogenesis the floor plate plays critical role (s) in differentiation of ventral portion of neural tube.The purpose of this study was to determine the
M.M Hasanzadeh- Taheri, M.R Nikravesh, M Jalali, A.R Fazel   +3 more
doaj  

Beyond Bactericidal: Plasma Surface Engineering to Defeat Food Matrix‐Conditioning Layers

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 6, November 2026.
ABSTRACT The persistence of foodborne pathogens on industrial food contact surfaces continues to challenge global food safety despite advances in sanitation technologies. A central limitation of current antimicrobial strategies lies in their validation under simplified laboratory conditions that overlook the physicochemically driven formation of food ...
Rafael Bianchini Fulindi, Argemiro Soares da Silva Sobrinho, Anderson S. Sant'Ana   +2 more
wiley   +1 more source

DNA display of glycoconjugates to emulate oligomeric interactions of glycans

Beilstein Journal of Organic Chemistry, 2015
Glycans (carbohydrate portion of glycoproteins and glycolipids) frequently exert their function through oligomeric interactions involving multiple carbohydrate units.
Alexandre Novoa, Nicolas Winssinger
doaj   +1 more source