Glycogen Synthase Kinase 3β in Cancer Biology and Treatment
Cells, 2020 Glycogen synthase kinase (GSK)3β is a multifunctional serine/threonine protein kinase with more than 100 substrates and interacting molecules. GSK3β is normally active in cells and negative regulation of GSK3β activity via phosphorylation of its serine 9
Takahiro Domoto +3 more
semanticscholar +1 more source
The involvement of GSK3β for glycogen synthesis throughout the annual cycle of Pacific oyster, Crassostrea gigas (Magallana gigas) [PDF]
, 2023 Crassostrea gigas is a frequently studied species in understanding physiological processes in bivalves. Similar to other animals, oysters store glucose in the body as glycogen. Glycogen is known to supply energy for germ cell development and maintenance.
Cadangin, Josel +5 more
core +2 more sources
Discovery and development of small-molecule inhibitors of glycogen synthase.
Journal of Medicinal Chemistry, 2020 The over-accumulation of glycogen appears as a hallmark in various glycogen storage diseases (GSDs), including Pompe, Cori, Andersen and Lafora disease.
B. Tang +12 more
semanticscholar +1 more source
Lipid metabolism in pancreatic cancer: emerging roles and potential targets
Cancer Communications, Volume 42, Issue 12, Page 1234-1256, December 2022., 2022 Abstract Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5‐year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection.
Xinpeng Yin +6 more
wiley +1 more source
Cancer Communications, Volume 42, Issue 12, Page 1347-1366, December 2022., 2022 Abstract Background N‐acetyltransferase 10 (NAT10) is the only enzyme known to mediate the N4‐acetylcytidine (ac4C) modification of mRNA and is crucial for mRNA stability and translation efficiency. However, its role in cancer development and prognosis has not yet been explored.
Xiao Zheng +8 more
wiley +1 more source
Glycogenin is Dispensable for Glycogen Synthesis in Human Muscle, and Glycogenin Deficiency Causes Polyglucosan Storage [PDF]
, 2020 Glycogenin is considered to be an essential primer for glycogen biosynthesis. Nevertheless, patients with glycogenin-1 deficiency due to biallelic GYG1 (NM_004130.3) mutations can store glycogen in muscle.
Dellgren, Göran +10 more
core +1 more source
Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States. [PDF]
PLoS ONE, 2015 Human pluripotent stem cells (hPSCs) represent very promising resources for cell-based regenerative medicine. It is essential to determine the biological implications of some fundamental physiological processes (such as glycogen metabolism) in these stem
Richard J Chen +6 more
doaj +1 more source
Alternative splicing of the porcine glycogen synthase kinase 3β (GSK-3β) gene with differential expression patterns and regulatory functions. [PDF]
PLoS ONE, 2012 Glycogen synthase kinase 3 (GSK3α and GSK3β) are serine/threonine kinases involved in numerous cellular processes and diverse diseases including mood disorders, Alzheimer's disease, diabetes, and cancer.
Linjie Wang +7 more
doaj +1 more source
Lafora disease offers a unique window into neuronal glycogen metabolism [PDF]
, 2018 Lafora disease (LD) is a fatal, autosomal recessive, glycogen-storage disorder that manifests as severe epilepsy. LD results from mutations in the gene encoding either the glycogen phosphatase laforin or the E3 ubiquitin ligase malin. Individuals with LD
Gentry, Matthew S. +4 more
core +2 more sources
Allosteric Regulation of Glycogen Synthase Controls Glycogen Synthesis in Muscle [PDF]
Cell Metabolism, 2010 Glycogen synthase (GS), a key enzyme in glycogen synthesis, is activated by the allosteric stimulator glucose-6-phosphate (G6P) and by dephosphorylation through inactivation of GS kinase-3 with insulin. The relative importance of these two regulatory mechanisms in controlling GS is not established, mainly due to the complex interplay between multiple ...
Kei Sakamoto +9 more
openaire +5 more sources