Results 131 to 140 of about 98,730 (257)

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

AMPK activation is sufficient to increase skeletal muscle glucose uptake and glycogen synthesis but is not required for contraction-mediated increases in glucose metabolism. [PDF]

Heliyon, 2022
Esquejo RM, Albuquerque B, Sher A, Blatnik M, Wald K, Peloquin M, Delmore J, Kindt E, Li W, Young JD, Cameron K, Miller RA.   +11 more
europepmc   +1 more source

Multi‐Target Pharmacological Mechanisms of Salvia miltiorrhiza Bunge in Metabolic Syndrome and Cardiovascular Diseases: A Comprehensive Review Based on the Theory of “Same Treatment for Different Diseases”

Phytotherapy Research, EarlyView.
Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia, Kaiyi Wu, Jiaying Qi, Nana Huang, Yusheng Liu, Xiumei Gao, Rong Sun   +6 more
wiley   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Aqueous Extract of Guava (Psidium guajava L.) Leaf Ameliorates Hyperglycemia by Promoting Hepatic Glycogen Synthesis and Modulating Gut Microbiota. [PDF]

Front Pharmacol, 2022
Chu S, Zhang F, Wang H, Xie L, Chen Z, Zeng W, Zhou Z, Hu F.   +7 more
europepmc   +1 more source

The Effect of Natural Compounds on Cognitive Impairment Through BDNF/TrkB/CREB Pathway: A Review

Phytotherapy Research, EarlyView.
Natural compounds improve cognitive function by activating BDNF/TrkB/CREB signaling to reduce neuroinflammation, oxidative stress, apoptosis, and Aβ accumulation while promoting synaptogenesis. ABSTRACT Considering the global prevalence of Alzheimer's disease (AD) and the restrictions of current treatment procedures, natural compounds (such as curcumin,
Vahid Pourbarkhordar, Sohrab Rahmani, Hossein Hosseinzadeh, Soghra Mehri   +3 more
wiley   +1 more source

Bombyxin II Regulates Glucose Absorption and Glycogen Synthesis through the PI3K Signaling Pathway in HepG2 Cells. [PDF]

Biomed Res Int, 2021
Yang H, Li H, Song Y, Sui Y, Du Z, Zhang G.   +5 more
europepmc   +1 more source

Design and synthesis of responsive glycopolymers for biomedical and environmental applications

Responsive Materials, EarlyView.
This review highlighted recent advances in the synthetic methodology of polymerization and post‐polymerization modification, which enable precise structural control and broaden the applications of responsive glycopolymers in biomedical and environmental fields. Abstract Glycopolymers are a unique class of synthetic polymers bearing pendant carbohydrate
Arpita Samal, Shubhi Dwivedi, Mahesh Peddigari, Abhijit Sau   +3 more
wiley   +1 more source

Linking visceral fat accumulation to gut microbiota: key bacterial taxa and their roles in the glycogen synthesis pathway. [PDF]

Exp Mol Med
Kim NE, Cho B, Kim Y, Kim G, Yie GE, Kim H, Park J, Kim H, Jeong C, Lee M, Joo Y, Lim S, Park S, Hong Y, Min K, Cho B, Yun JM, Jung ES, Ji Y, Cho S, Seong JK, Park H, Park JH, Won S.   +23 more
europepmc   +1 more source

Coingestion of Carbohydrate and Protein on Muscle Glycogen Synthesis after Exercise: A Meta-analysis. [PDF]

Med Sci Sports Exerc, 2021
Margolis LM, Allen JT, Hatch-McChesney A, Pasiakos SM.   +3 more
europepmc   +1 more source