Results 121 to 130 of about 98,730 (257)

Role of hepatic PKCβ in nutritional regulation of hepatic glycogen synthesis. [PDF]

JCI Insight, 2021
Shu Y, Hassan F, Ostrowski MC, Mehta KD.
europepmc   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Empagliflozin Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis by AMPK/CREB/GSK3β Signalling Pathway. [PDF]

Front Physiol, 2022
Yu X, Meng Z, Fang T, Liu X, Cheng Y, Xu L, Liu X, Li X, Xue M, Li T, Sun B, Chen L.   +11 more
europepmc   +1 more source

Incretin‐Based Therapies: A Testable Hypothesis Linking Incretin Signaling, Mitochondrial Redox, and OXPHOS Efficiency

Obesity, EarlyView.
ABSTRACT Objective Incretin‐based obesity therapies (IBTs), especially GLP‐1 receptor agonists (GLP‐1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns ...
Bryn Falahee, Caroline M. Apovian, Nawfal Istfan   +2 more
wiley   +1 more source

Uridine alleviates high-carbohydrate diet-induced metabolic syndromes by activating sirt1/AMPK signaling pathway and promoting glycogen synthesis in Nile tilapia (Oreochromis niloticus). [PDF]

Anim Nutr, 2023
Zhou NN, Wang T, Lin YX, Xu R, Wu HX, Ding FF, Qiao F, Du ZY, Zhang ML.   +8 more
europepmc   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice. [PDF]

Acta Pharmacol Sin, 2023
Huang SL, Xie W, Ye YL, Liu J, Qu H, Shen Y, Xu TF, Zhao ZH, Shi Y, Shen JH, Leng Y.   +10 more
europepmc   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source

Postexercise muscle glycogen synthesis with glucose, galactose, and combined galactose-glucose ingestion.

Am J Physiol Endocrinol Metab, 2023
Podlogar T, Shad BJ, Seabright AP, Odell OJ, Lord SO, Civil R, Salgueiro RB, Shepherd EL, Lalor PF, Elhassan YS, Lai YC, Rowlands DS, Wallis GA.   +12 more
europepmc   +1 more source

Polygonatum sibiricum saponin Exerts Beneficial Hypoglycemic Effects in Type 2 Diabetes Mice by Improving Hepatic Insulin Resistance and Glycogen Synthesis-Related Proteins. [PDF]

Nutrients, 2022
Chen Z, Luo J, Jia M, Chai Y, Bao Y.
europepmc   +1 more source