Results 101 to 110 of about 98,730 (257)

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancer. [PDF]

Cell Death Dis, 2023
Hasani S, Young LEA, Van Nort W, Banerjee M, Rivas DR, Kim J, Xiong X, Sun RC, Gentry MS, Sesaki H, Gao T.   +10 more
europepmc   +1 more source

Subchronic Exposure to Cannabis‐Based Nanoemulsions Induces Histopathological and Molecular Alterations in the Rat Submandibular Gland

Journal of Applied Toxicology, EarlyView.
ABSTRACT The increasing therapeutic incorporation of cannabis has expanded phytocannabinoid application, yet peripheral adverse effects like xerostomia raise concerns regarding emerging biotechnological formulations. This study evaluated the effects of cannabis‐based lipid nanoemulsions on the rat submandibular gland parenchyma.
Lorrany Avanci Bullo, Gabriel Carvalhal de Aguiar, Daniel Vitor Souza, Barbara dos Anjos Rosário, Flavia de Oliveira, Fernando Augusto Cintra Magalhaes, Nágila Maria Pontes Silva Ricardo, Edilberto Rocha Silveira, Dávila Zampieri, Milena de Barros Viana, Daniel Araki Ribeiro   +10 more
wiley   +1 more source

GSK3 Inhibition During Annelid Head Regeneration Results in a Hyper‐Proliferative Blastema and Impaired Differentiation

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
A whole‐body regenerative annelid was treated with a GSK3 inhibitor. While posterior regeneration was mostly normal, GSK3 inhibition prevented differentiation of anterior‐specific structures and instead produced a persistent, oversized, hyper‐proliferative blastema. This suggests that GSK3 promotes anterior identity and halts proliferation during axial
James D. Nowotny, Eduardo E. Zattara, Maria Balarezo, Kevin G. Nyberg, Kenna M. Costello, Alexandra E. Bely   +5 more
wiley   +1 more source

Ginsenoside Rb1 Promotes Hepatic Glycogen Synthesis to Ameliorate T2DM Through 15-PGDH/PGE₂/EP4 Signaling Pathway. [PDF]

Diabetes Metab Syndr Obes, 2023
Liang M, Zhan W, Wang L, Bei W, Wang W.
europepmc   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

Two Diseases-One Preclinical Treatment Targeting Glycogen Synthesis. [PDF]

Neurotherapeutics, 2022
Gentry MS, Markussen KH, Donohue KJ.
europepmc   +1 more source

Gastroprotective effects of Sapodilla fruit powder against ethanol‐induced gastric injury in Sprague–Dawley rats: In silico prediction and in vivo validation

JSFA reports, EarlyView.
Abstract Background Gastrointestinal disorders are rapidly increasing worldwide due to the disturbance of mucosal defenses. Manilkara zapota possesses significant therapeutic attributes to improve individual well‐being. Objectives The current study was conducted to evaluate the antioxidant activity, phytochemical characterization, and in silico and in ...
Ayesha Siddiqa, Adnan Amjad, Muhammad Maaz, Ahmad Mujtaba Noman, Tadesse Fenta Yehuala, Shehnshah Zafar, Syeda Khimar Zahra Kazmi, Duaa Tariq   +7 more
wiley   +1 more source

Peaches (Prunus persica L.) pulp mitigate type 2 diabetic mice by modulating of glucose metabolism and gut microbiota

Food Science and Human Wellness
Peach are a fruit with high nutritional and economic value, but their safety and suitability for diabetic patients have been questioned. This study investigated the effects and potential mechanisms of peach pulp (PP) on type 2 diabetes mellitus (T2DM) in
Leyi Zhou, Jianfen Ye, Yingying Wei, Mouayche Salma, Shu Jiang, Yi Chen, Xingfeng Shao   +6 more
doaj   +1 more source

Distribution of Exonic Variants in Glycogen Synthesis and Catabolism Genes in Late Onset Pompe Disease (LOPD). [PDF]

Curr Issues Mol Biol, 2023
De Filippi P, Errichiello E, Toscano A, Mongini T, Moggio M, Ravaglia S, Filosto M, Servidei S, Musumeci O, Giannini F, Piperno A, Siciliano G, Ricci G, Di Muzio A, Rigoldi M, Tonin P, Croce MG, Pegoraro E, Politano L, Maggi L, Telese R, Lerario A, Sancricca C, Vercelli L, Semplicini C, Pasanisi B, Bembi B, Dardis A, Palmieri I, Cereda C, Valente EM, Danesino C.   +31 more
europepmc   +1 more source