Results 81 to 90 of about 98,730 (257)
Animal Research and One Health, EarlyView.In this study, we used cross‐species comparisons to identify ruminant hepatocyte features. We also identified potential genes and TFs involved in coordinating gluconeogenesis in ruminant hepatocytes. By integrating single‐cell data with population genetic analyses, we further identified candidate genetic variation in glucose metabolism and ...
Yaqi Zhou +6 more
wiley +1 more source
Animal Research and One Health, EarlyView.Integrated phenotypic, histological, transcriptomic, and validation analyses reveal that emaciation syndrome in Plectropomus leopardus is associated with intestinal structural damage, hepatic metabolic remodeling, and muscle protein degradation, highlighting coordinated multi‐tissue alterations underlying disease progression.
Zhihao Zhang +11 more
wiley +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2023 Mingjie Liang,1,2,* Wenjing Zhan,1,2,* Lexun Wang,1,2 Weijian Bei,1,2 Weixuan Wang1,2 1Traditional Chinese Medicine Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, People’s Republic of China; 2Guangdong ...
Liang M, Zhan W, Wang L, Bei W, Wang W
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Glycogen Synthesis from Pyruvate in Muscle [PDF]
Nature, 1966 UNDER normal conditions glucose is the major source of muscle glycogen. In muscle, pyruvate and lactate make only a minimal contribution to glycogen but the liver can freely convert these compounds into glycogen1,2. One of the key enzymes in the process of glycogenesis in liver is fructose-l,6-diphosphatase (FDPase)3, and the inability of muscle to ...
openaire +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk +5 more
wiley +1 more source
Synthesis of Glycogen Fractions by Heart Homogenates.
Experimental Biology and Medicine, 1955 SummaryGlycolysis reduces both glycogen fractions of the rat heart at about the same rate for the first 5 minutes, regardless of the medium used for suspension of the tissue. In Krebs Phosphate Ringer's solution and in unoxygenated 5.4% glucose, the 2 glycogens drop to a low, but stable level.
D K, MEYER +4 more
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British Journal of Clinical Pharmacology, EarlyView.SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić +7 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden +3 more
wiley +1 more source
Initiation of glycogen synthesis. Control of glycogenin by glycogen phosphorylase.
Journal of Biological Chemistry, 1993 Glycogen biosynthesis involves a specific initiation event, mediated by a specialized protein, glycogenin. Glycogenin undergoes self-glucosylation to generate an oligosaccharide primer, which, when long enough, supports the action of glycogen synthase to elongate the polysaccharide chain, leading ultimately to the formation of glycogen.
Y, Cao +3 more
openaire +2 more sources
Cytoskeleton, EarlyView.ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith +9 more
wiley +1 more source