Results 61 to 70 of about 10,062 (222)

Bacterial Glycolipid Activation of Cd1d-Restricted Nkt Cells [PDF]

open access: yes, 2023
Disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, methods of improving vaccine efficacy, and methods of treating an infection.

core   +2 more sources

Heat Stress in Quail: Impacts on Health and Productivity, and Mitigation Strategies

open access: yesAnimal Research and One Health, EarlyView.
Heat stress disrupts physiological homeostasis in quail, inducing oxidative stress, immune dysregulation, and metabolic imbalance, which impair growth, reproduction, product quality, and welfare. Integrating nutritional, environmental, and genetic–epigenetic strategies enhances thermotolerance, sustains productivity, and supports climate‐smart quail ...
T. A. Eletu   +6 more
wiley   +1 more source

Cellular and thylakoid-membrane glycolipids of Chlamydomonas reinhardtii 137+.

open access: yesJournal of Lipid Research, 1981
The glycolipids of the green alga Chlamydomonas reinhardtii 137+ have been quantitated in the phototrophically-cultured cell and in its thylakoid membrane. Three lipids, the galactolipids monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol
D R Janero, R Barrnett
doaj   +1 more source

Glycolipid receptors for verotoxin and Helicobacter pylori: role in pathology [PDF]

open access: yes, 1999
Eukaryotic cell surface glycolipids can act as both the primary interface between bacteria and their host and secondly as a targeting mechanism for bacterial virulence factors.
Lingwood, Clifford A   +1 more
core   +1 more source

A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells

open access: yesChemistry – A European Journal, EarlyView.
A microbial metabolite covalently binds immunological protein MR1 to potently activate specific lymphocytes called MAIT cells, but it is too unstable for biological applications. Here, using synthesis, assays, protein crystallography, and computer modelling, we report a water‐stable analogue that activates reporter cells expressing the MAIT T cell ...
Jeffrey Y. W. Mak   +9 more
wiley   +1 more source

Glycolipid-peptide conjugate vaccines enhance CD8+ T cell responses against human viral proteins

open access: yes, 2017
An important goal of vaccination against viruses and virus-driven cancers is to elicit cytotoxic CD8+ T cells specific for virus-derived peptides. CD8+ T cell responses can be enhanced by engaging help from natural killer T (NKT) cells.
Axel Heiser (10099146)   +13 more
core  

Vesicular traffic in polarized epithelial cells : identification and characterization of general and epithelial specific factors [PDF]

open access: yes, 1994
Polarized epithelial cells are differentiated into apical and basolateral plasma membrane domains separated by tight junctions. The apical cell surface usually faces the external milieu, the basolateral domain provides cell-cell and cell-substratum ...
Fiedler, Klaus
core   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara   +20 more
wiley   +1 more source

Helicobacter suis binding to carbohydrates on human and porcine gastric mucins and glycolipids occurs via two modes

open access: yesVirulence, 2018
Helicobacter suis colonizes the stomach of most pigs and is the most prevalent non-Helicobacter pylori Helicobacter species found in the human stomach. In the human host, H.
Médea Padra   +13 more
doaj   +1 more source

Neuraminidase-3 Is a Negative Regulator of LFA-1 Adhesion

open access: yesFrontiers in Chemistry, 2019
Within the plasma membrane environment, glycoconjugate-receptor interactions play an important role in the regulation of cell-cell interactions. We have investigated the mechanism and activity of the human neuraminidase (NEU) isoenzyme, NEU3, on T cell ...
Md. Amran Howlader   +5 more
doaj   +1 more source

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