Immunoglobulin G glycome composition in transition from premenopause to postmenopause [PDF]
iScience, 2022 Summary: Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
Helena Deriš +11 more
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The glycome of normal and malignant plasma cells.
PLoS ONE, 2013 The glycome, i.e. the cellular repertoire of glycan structures, contributes to important functions such as adhesion and intercellular communication. Enzymes regulating cellular glycosylation processes are related to the pathogenesis of cancer including ...
Thomas M Moehler +12 more
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The effect of blood sampling and preanalytical processing on human N-glycome. [PDF]
PLoS ONE, 2018 Glycome modulations have been described in the onset and progression of many diseases. Thus, many studies have proposed glycans from blood glycoproteins as disease markers.
Tereza Dědová +5 more
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Plasma protein N-glycome composition associates with postprandial lipaemic response
BMC Medicine, 2023 Background A dysregulated postprandial metabolic response is a risk factor for chronic diseases, including type 2 diabetes mellitus (T2DM). The plasma protein N-glycome is implicated in both lipid metabolism and T2DM risk. Hence, we first investigate the
Panayiotis Louca +14 more
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Immunoglobulin G N-Glycome as a biomarker of mortality risk in Escherichia coli induced sepsis [PDF]
Frontiers in ImmunologyBackgroundSepsis is a life-threatening syndrome caused by an imbalance in the inflammatory response to an infection that can lead to a high mortality rate. Escherichia coli is a common pathogen that causes sepsis.
Huachen Wang +9 more
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Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches
BMJ Open Diabetes Research & Care, 2021 Introduction Prediction of type 2 diabetes mellitus (T2DM) and its preceding factors, such as insulin resistance (IR), is of great importance as it may allow delay or prevention of onset of the disease. Plasma protein N-glycome has emerged as a promising
Gordan Lauc +7 more
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Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn’s Disease [PDF]
Biomolecules, 2023 Crohn’s disease (CD) is a chronic inflammation of the digestive tract that significantly impairs patients’ quality of life and well-being. Anti-TNF biologicals revolutionised the treatment of CD, yet many patients do not adequately respond to such ...
Maja Hanić +10 more
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Impact of different pathogen classes on the serum N-glycome in septic shock
BBA AdvancesThe morbidity and mortality of sepsis remain high. Clinicians lack effective markers to rapidly diagnose sepsis and identify the underlying pathogen infection particularly for patients with candidaemia or cases of culture-negative sepsis where culture ...
Helena Torpy +6 more
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Non-targeted N-glycome profiling reveals multiple layers of organ-specific diversity in mice
Nature CommunicationsN-glycosylation is one of the most common protein modifications in eukaryotes, with immense importance at the molecular, cellular, and organismal level.
Johannes Helm +7 more
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FEMS Microbiology Reviews, 2005 Microbial cell surface glycans in the form of glycolipids and glycoproteins frequently play important roles in cell-cell interaction and host immune responses.
A KARLYSHEV, J KETLEY, B WREN
openaire +2 more sources