Results 11 to 20 of about 6,080 (220)
Immunoglobulin G N-Glycome as a biomarker of mortality risk in Escherichia coli induced sepsis [PDF]
Frontiers in ImmunologyBackgroundSepsis is a life-threatening syndrome caused by an imbalance in the inflammatory response to an infection that can lead to a high mortality rate. Escherichia coli is a common pathogen that causes sepsis.
Huachen Wang +9 more
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Plasma protein N-glycome composition associates with postprandial lipaemic response
BMC Medicine, 2023 Background A dysregulated postprandial metabolic response is a risk factor for chronic diseases, including type 2 diabetes mellitus (T2DM). The plasma protein N-glycome is implicated in both lipid metabolism and T2DM risk. Hence, we first investigate the
Panayiotis Louca +14 more
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Engineering, 2023 “Life requires more than nucleic acids and proteins; sweet sugar molecules could be another life code beyond the central dogma of molecular biology.†…
Wei Wang, Baofeng Yang
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Impact of different pathogen classes on the serum N-glycome in septic shock [PDF]
BBA AdvancesThe morbidity and mortality of sepsis remain high. Clinicians lack effective markers to rapidly diagnose sepsis and identify the underlying pathogen infection particularly for patients with candidaemia or cases of culture-negative sepsis where culture ...
Helena Torpy +6 more
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Effects of low-calorie and different weight-maintenance diets on IgG glycome composition
Frontiers in Immunology, 2022 Obesity-induced inflammation activates the adaptive immune system by altering immunoglobulin G (IgG) glycosylation in a way to produce more proinflammatory antibodies. The IgG glycome has already been well studied, and its alterations are correlated with
Helena Deriš +9 more
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Mouse tissue glycome atlas 2022 highlights inter-organ variation in major N-glycan profiles
Scientific Reports, 2022 This study presents “mouse tissue glycome atlas” representing the profiles of major N-glycans of mouse glycoproteins that may define their essential functions in the surface glycocalyx of mouse organs/tissues and serum-derived extracellular vesicles ...
Michiru Otaki +6 more
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Urinary extracellular vesicle N-glycomics identifies diagnostic glycosignatures for bladder cancer [PDF]
Nature CommunicationsBladder cancer (BC) is the most common urologic malignancy, facing enormous diagnostic challenges. Urinary extracellular vesicles (EVs) are promising source for developing diagnostic markers for bladder cancer because of the direct contact between urine ...
Yang Li +10 more
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Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India
Microorganisms, 2021 Background: Non-communicable diseases (NCDs) have become a major cause of morbidity and mortality in India. Perturbation of host–microbiome interactions may be a key mechanism by which lifestyle-related risk factors such as tobacco use, alcohol ...
Tanya M. Monaghan +22 more
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Proceedings of the National Academy of Sciences, 2009 Molecular imaging enables visualization of specific molecules in vivo and without substantial perturbation to the target molecule's environment. Glycans are appealing targets for molecular imaging but are inaccessible with conventional approaches.
Scott T, Laughlin, Carolyn R, Bertozzi
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Shotgun glycomics: a microarray strategy for functional glycomics [PDF]
Nature Methods, 2010 Major challenges of glycomics are to characterize a glycome and identify functional glycans as ligands for glycan-binding proteins (GBPs). To address these issues we developed a general strategy termed shotgun glycomics. We focus on glycosphingolipids (GSLs), a class of glycoconjugates that is challenging to study, recognized by toxins, antibodies and ...
Song, Xuezheng +9 more
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