Results 11 to 20 of about 75,906 (337)

pGlycoQuant with a deep residual network for quantitative glycoproteomics at intact glycopeptide level

Nature Communications, 2022
Software tools for larger-scale intact glycopeptide quantification lag far behind, which hinders exploring the differential sitespecific glycosylation.
Siyuan Kong, Pengyun Gong, Wen-Feng Zeng, Biyun Jiang, Xinhang Hou, Yang Zhang, Huanhuan Zhao, Mingqi Liu, Guoquan Yan, Xinwen Zhou, Xihua Qiao, Mengxi Wu, Pengyuan Yang, Chao Liu, Weiqian Cao   +14 more
doaj   +2 more sources

Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities. [PDF]

Angew Chem Int Ed Engl
Non‐canonical glycopeptides of the proteoglycan linkage region are accessible by the enzymes B3GalT6 and GlcAT‐1 confirming a recently discovered rescue mode in glycosaminoglycan (GAG) biosynthesis. The crystal structure of B3GalT6 revealed a covalent dimer linked by a disulfide. Abstract We selected the N,O‐glycosylated proteoglycan bikunin as a model
Weidler S, Bundgaard O, Hessefort M, Rädisch M, Graf CGF, Lam K, Neubauer VJ, Eisenreich J, Köhler L, Moremen KW, Steentoft C, Clausen H, Huang TY, Hung SC, Steegborn C, Weyand M, Unverzagt C.   +16 more
europepmc   +3 more sources

Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis

Nature Methods, 2021
Glycoproteomics is a powerful yet analytically challenging research tool. Software packages aiding the interpretation of complex glycopeptide tandem mass spectra have appeared, but their relative performance remains untested.
R. Kawahara, A. Chernykh, K. Alagesan, M. Bern, Weiqian Cao, R. Chalkley, Kai Cheng, Matthew S F Choo, N. Edwards, R. Goldman, M. Hoffmann, Yingwei Hu, Yifan Huang, J. Kim, Doron Kletter, B. Liquet, Mingqi Liu, Y. Mechref, Bo Meng, S. Neelamegham, Terry Nguyen-Khuong, J. Nilsson, Ádám Pap, Gun Wook Park, B. Parker, Cassandra L. Pegg, J. Penninger, Toan K. Phung, Markus Pioch, E. Rapp, Enes Sakalli, M. Sanda, B. Schulz, Nichollas E. Scott, G. Sofronov, J. Stadlmann, S. Vakhrushev, Christina M. Woo, Hung-Yi Wu, Pengyuan Yang, W. Ying, Hui Zhang, Yong Zhang, Jingfu Zhao, J. Zaia, S. Haslam, G. Palmisano, J. Yoo, G. Larson, K. Khoo, K. Medzihradszky, D. Kolarich, N. Packer, M. Thaysen‐Andersen   +53 more
semanticscholar   +1 more source

Recent Advances in the Development of Semisynthetic Glycopeptide Antibiotics: 2014–2022

ACS Infectious Diseases, 2022
The accelerated appearance of drug-resistant bacteria poses an ever-growing threat to modern medicine’s capacity to fight infectious diseases. Gram-positive species such as methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae ...
Emma van Groesen, P. Innocenti, N. Martin   +2 more
semanticscholar   +1 more source

ZIC-cHILIC-Based StageTip for Simultaneous Glycopeptide Enrichment and Fractionation toward Large-Scale N-Sialoglycoproteomics.

Analytical Chemistry, 2021
Alterations of protein glycosylation are closely related with pathophysiological regulation. Due to the structural macro- and microheterogeneity, low stoichiometry, and low ionization efficiency of glycopeptides, high-performance tools to enrich ...
Yi-Ju Chen, T. Yen, Yu-Hsien Lin, Yan-lin Chen, K. Khoo, Yu‐Ju Chen   +5 more
semanticscholar   +1 more source

O-Pair Search with MetaMorpheus for O-glycopeptide Characterization

Nature Methods, 2020
We report O-Pair Search, an approach to identify O-glycopeptides and localize O-glycosites. Using paired collision- and electron-based dissociation spectra, O-Pair Search identifies O-glycopeptides via an ion-indexed open modification search and ...
Lei Lu, N. Riley, M. Shortreed, C. Bertozzi, Lloyd M. Smith   +4 more
semanticscholar   +1 more source

Recent advances in software tools for more generic and precise intact glycopeptide analysis.

Molecular & Cellular Proteomics, 2020
Intact glycopeptide identification has long been known as a key and challenging barrier to the comprehensive and accurate understanding the role of glycosylation in an organism.
Weiqian Cao, Mingqi Liu, Siyuan Kong, Mengxi Wu, Yang Zhang, Pengyuan Yang   +5 more
semanticscholar   +1 more source

Bacterial Cell Wall Analogue Peptides Control the Oligomeric States and Activity of the Glycopeptide Antibiotic Eremomycin: Solution NMR and Antimicrobial Studies

Pharmaceuticals, 2021
For some time, glycopeptide antibiotics have been considered the last line of defense against Methicillin-resistant Staphylococcus aureus (MRSA). However, vancomycin resistance of Gram-positive bacteria is an increasingly emerging worldwide health ...
László Izsépi, Réka Erdei, Anna N. Tevyashova, Natalia E. Grammatikova, Andrey E. Shchekotikhin, Pál Herczegh, Gyula Batta   +6 more
doaj   +1 more source

Glycomic analysis of high density lipoprotein shows a highly sialylated particle. [PDF]

, 2014
Many of the functional proteins and lipids in high density lipoprotein (HDL) particles are potentially glycosylated, yet very little is known about the glycoconjugates of HDL.
German, J Bruce, Huang, Jincui, Lebrilla, Carlito B, Lee, Hyeyoung, Rivera, Nancy, Smilowitz, Jennifer T, Zivkovic, Angela M   +6 more
core   +1 more source

Phosphonopeptides Revisited, in an Era of Increasing Antimicrobial Resistance [PDF]

, 2020
Given the increase in resistance to antibacterial agents, there is an urgent need for the development of new agents with novel modes of action. As an interim solution, it is also prudent to reinvestigate old or abandoned antibacterial compounds to assess
Anderson, Rosaleen, Bedernjak, Alexandre F., Cummings, Stephen P., Day, Kathryn M., Gray, Mark, Jones, Amanda L., Marrs, Emma C.L., Perry, John D., Varadi, Linda   +8 more
core   +2 more sources