Results 41 to 50 of about 23,942 (220)

Exploiting gene regulation as an approach to identify, analyze and utilize the biosynthetic pathways of the glycopeptide ristomycin A and the zincophore [S,S]-EDDS in Amycolatopsis japonicum [PDF]

, 2017
The microbial secondary metabolism is a rich source for valuable products that have found their way into various clinical and industrial applications. A particularly productive bacterial genus for the discovery of natural products is Amycolatopsis.
Spohn, Marius
core   +1 more source

Immobilised teicoplanin does not demonstrate antimicrobial activity against Staphylococcus aureus

Scientific Reports, 2022
Antibacterial bone biomaterial coatings appeal to orthopaedics, dentistry and veterinary medicine. Achieving the successful, stable conjugation of suitable compounds to biomaterial surfaces is a major challenge.
S. Britton, K. Lee, L. Azizova, G. Shaw, W. Nishio Ayre, J. P. Mansell   +5 more
doaj   +1 more source

Genetics Behind the Glycosylation Patterns in the Biosynthesis of Dalbaheptides

Frontiers in Chemistry, 2022
Glycopeptide antibiotics are valuable natural metabolites endowed with different pharmacological properties, among them are dalbaheptides used to treat different infections caused by multidrug-resistant Gram-positive pathogens. Dalbaheptides are produced
Oleksandr Yushchuk, Oleksandr Yushchuk, Kseniia Zhukrovska, Francesca Berini, Victor Fedorenko, Flavia Marinelli   +5 more
doaj   +1 more source

Aminoalkylamides of Eremomycin Exhibit an Improved Antibacterial Activity

Pharmaceuticals, 2021
After decades, the glycopeptide vancomycin is still the preferred antibiotic against resistant strains of Gram-positive bacteria. Although its clinical use is strictly regulated, the gradual spread of vancomycin-resistant bacteria, such as glycopeptide ...
Elena I. Moiseenko, Réka Erdei, Natalia E. Grammatikova, Elena P. Mirchink, Elena B. Isakova, Eleonora R. Pereverzeva, Gyula Batta, Andrey E. Shchekotikhin   +7 more
doaj   +1 more source

Preliminary evaluation of probiotic properties of Lactobacillus strains isolated from Sardinian dairy products [PDF]

, 2014
Twenty-three Lactobacillus strains of dairy origin were evaluated for some functional properties relevant to their use as probiotics. A preliminary subtractive screening based on the abilities to inhibit the growth of microbial pathogens and hydrolyze ...
Conti S, Cosentino S, Deiana M, Deplano M, Fadda ME, Melis MP, Pisano MB, Viale S   +7 more
core   +1 more source

Specificity of Induction of Glycopeptide Antibiotic Resistance in the Producing Actinomycetes

Antibiotics, 2018
Glycopeptide antibiotics are drugs of last resort for treating severe infections caused by Gram-positive pathogens. It is widely believed that glycopeptide-resistance determinants (van genes) are ultimately derived from the producing actinomycetes.
Elisa Binda, Pamela Cappelletti, Flavia Marinelli, Giorgia Letizia Marcone   +3 more
doaj   +1 more source

Antimicrobial stewardship in high-risk febrile neutropenia patients

Antimicrobial Resistance and Infection Control, 2022
Background The 2011 4th European Conference on Infections in Leukemia (ECIL4) guidelines recommend antibiotics de-escalation/discontinuation in selected febrile neutropenia (FN) patients. We aimed to assess the impact of an antimicrobial stewardship (AMS)
Adrien Contejean, Salam Abbara, Ryme Chentouh, Sophie Alviset, Eric Grignano, Nabil Gastli, Anne Casetta, Lise Willems, Etienne Canouï, Caroline Charlier, Frédéric Pène, Julien Charpentier, Jeanne Reboul-Marty, Rui Batista, Didier Bouscary, Solen Kernéis   +15 more
doaj   +1 more source

Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin [PDF]

, 2017
VanA-type resistance to glycopeptide antibiotics in clinical enterococci is regulated by the VanSARA two-component signal transduction system. The nature of the molecular ligand that is recognised by the VanSA sensory component has not hitherto been ...
AM Stock, AT Ulijasz, C Rayner, CA Potter, CA Potter, CP Zschiedrich, D Kahne, EJ Capra, G Batta, G Werner, GD Wright, H Kinouchi, J Dam, J Grissom-Arnold, JM Creeth, JM Creeth, JP Mackay, JP Waltho, K Koteva, M Arthur, M Arthur, M Arthur, M Arthur, M Baptista, M Baptista, M Jung Kwun, M Nieto, M Rholam, M-C Tseng, MH Lai, N Mani, NE Allen, P Courvalin, P Courvalin, P Groves, P Ma, P Schuck, PE Reynolds, PJ Loll, RB Gillis, RJ Willems, S Ang, S Handwerger, SG Patching, U Gerhard, Y Nakama, Z-G Jia   +46 more
core   +5 more sources

Biosynthesis of Antibacterial Iron-Chelating Tropolones in Aspergillus nidulans as Response to Glycopeptide-Producing Streptomycetes

Frontiers in Fungal Biology, 2022
The soil microbiome comprises numerous filamentous fungi and bacteria that mutually react and challenge each other by the production of bioactive secondary metabolites. Herein, we show in liquid co-cultures that the presence of filamentous Streptomycetes
Jennifer Gerke, Anna M. Köhler, Jan-Peer Wennrich, Jan-Peer Wennrich, Verena Große, Lulu Shao, Lulu Shao, Antje K. Heinrich, Helge B. Bode, Helge B. Bode, Wanping Chen, Frank Surup, Frank Surup, Gerhard H. Braus   +13 more
doaj   +1 more source

Synthesis of (–)-Bulgecinine and 5-epi-Bulgecinine through Proline-Catalysed Asymmetric α-Hydroxylation of an Aldehyde Derived from l-Glutamic Acid

SynOpen, 2019
A very efficient synthetic route to (–)-bulgecinine and 5-epibulgecinine from an aldehyde derived from l-glutamic acid is reported. Proline-catalysed asymmetric α-hydroxylation reaction of an aldehyde is the key step in this synthesis, which is used to ...
Vipin Kumar Jain, Mrityunjay Kumar
doaj   +1 more source