Results 31 to 40 of about 23,942 (220)

Affinities and in-plane stress forces between glycopeptide antibiotics and biomimetic bacterial membranes

Sensing and Bio-Sensing Research, 2015
Understanding the molecular basis of interactions between antibiotics affecting bacterial cell wall biosynthesis and cellular membranes is important in rational drug design of new drugs to overcome resistance.
Sisi Bi, Andrea Ranzoni, Johnny X. Huang, Karl Hansford, Matthew A. Cooper   +4 more
doaj   +1 more source

Risk factors for failure of outpatient parenteral antibiotic therapy (OPAT) in infective endocarditis [PDF]

, 2013
Objectives: To identify risk factors for failure of outpatient antibiotic therapy (OPAT) in infective endocarditis (IE). Patients and methods: We identified IE cases managed at a single centre over 12 years from a prospectively maintained database. ‘
Barr, D. A., Duncan, C. J. A., Ho, A., Seaton, R. A., Semple, L., Sharp, E.   +5 more
core   +1 more source

New Avoparcin-like Molecules from the Avoparcin Producer Amycolatopsis coloradensis ATCC 53629

Fermentation, 2022
Amycolatopsis coloradensis ATCC 53629 is the producer of the glycopeptide antibiotic avoparcin. While setting up the production of the avoparcin complex, in view of its use as analytical standard, we uncovered the production of a to-date not described ...
Gina Ramoni, Carmine Capozzoli, Adriana Bava, Francesca Foschi, Gianluigi Broggini, Fabrizio Beltrametti   +5 more
doaj   +1 more source

Impact of Linker Modification and PEGylation of Vancomycin Conjugates on Structure-Activity Relationships and Pharmacokinetics

Pharmaceuticals, 2022
As multidrug-resistant bacteria represent a concerning burden, experts insist on the need for a dramatic rethinking on antibiotic use and development in order to avoid a post-antibiotic era.
Florian Umstätter, Julia Werner, Leah Zerlin, Eric Mühlberg, Christian Kleist, Karel D. Klika, Tobias Hertlein, Barbro Beijer, Cornelius Domhan, Stefan Zimmermann, Knut Ohlsen, Uwe Haberkorn, Walter Mier, Philipp Uhl   +13 more
doaj   +1 more source

Combinations of β-lactam or aminoglycoside antibiotics with plectasin are synergistic against methicillin-sensitive and methicillin-resistant Staphylococcus aureus. [PDF]

, 2015
Bacterial infections remain the leading killer worldwide which is worsened by the continuous emergence of antibiotic resistance. In particular, methicillin-sensitive (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) are prevalent and the ...
A Anantharaman, A Elemam, A Giacometti, AF Zuluaga, AL Barry, Alexander Liu, Angela Kearns, Anthony Coates, AR Coates, B Mazurek, B Zechini, Brigita Vaiciunaite, C Ostergaard, CA Arias, Christiana Moigboi, CT Mascio, D Andes, D Harmsen, DE Fry, EJ Toone, EL Chan, FC Odds, H Lam, HW Boucher, J Yoon, James Vaudrey, JM Pages, JR Aeschlimann, K Hiramatsu, KS Brinch, L Cui, L Kalan, M Aligholi, M Magret, M Shahid, M Wu, NC Gordon, Oliver Schildgen, P Cottagnoud, PE Reynolds, PH Mygind, RC Moellering Jr, RE Hancock, RL Hill, Sharla M. McTavish, T Schneider, W Yuan, WE Alborn Jr, Y Hu, Y Hu, Y Quiros, Y Zhang, Yanmin Hu, YQ Xiong   +53 more
core   +3 more sources

Glycopeptide Antibiotic Resistance Genes: Distribution and Function in the Producer Actinomycetes

Frontiers in Microbiology, 2020
Glycopeptide antibiotics (GPAs) are considered drugs of “last resort” for the treatment of life-threatening infections caused by relevant Gram-positive pathogens (enterococci, staphylococci, and clostridia).
Oleksandr Yushchuk, Elisa Binda, Flavia Marinelli   +2 more
doaj   +1 more source

In Vivo Characterization of the Activation and Interaction of the VanR-VanS Two-Component Regulatory System Controlling Glycopeptide Antibiotic Resistance in Two Related Streptomyces Species. [PDF]

, 2015
This is the author accepted manuscript. The final version is available from the American Society for Microbiology via http://dx.doi.org/10.1128/AAC.01367-15The VanR-VanS two-component system is responsible for inducing resistance to glycopeptide ...
Hong, Hee-Jeon, Kwun, Min Jung, Novotna, Gabriela Balikova   +2 more
core   +1 more source

Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A

Angewandte Chemie, EarlyView.
Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham, Edward S. Hems, Daniel C. L. Van, Justin E. Clarke, Sergey Nepogodiev, Julius S. P. Adamson, Christian Bassi, Michael E. Webb, Glyn R. Hemsworth, Orde Q. Munro, Barrie Wilkinson, Ryan F. Seipke   +11 more
wiley   +2 more sources

Measurement of teicoplanin by liquid chromatography-tandem mass spectrometry:development of a novel method [PDF]

, 2012
Teicoplanin is an antibiotic used for the treatment of endocarditis, osteomyelitis, septic arthritis and methicillin-resistant Staphylococcus aureus. Teicoplanin is emerging as a suitable alternative antibiotic to vancomycin, where their trough serum ...
Bailey, Lisa M, Davison, Andrew S, Dutton, John, Fung, Francis H Y, Hopkins, John P P, Tang, Jonathan C Y   +5 more
core   +1 more source

Looking Back to Amycolatopsis: History of the Antibiotic Discovery and Future Prospects

Antibiotics, 2021
The emergence of antibiotic-resistant pathogenic bacteria in recent decades leads us to an urgent need for the development of new antibacterial agents. The species of the genus Amycolatopsis are known as producers of secondary metabolites that are used ...
Olga V. Kisil, Tatiana A. Efimenko, Olga V. Efremenkova   +2 more
doaj   +1 more source