Results 51 to 60 of about 23,942 (220)

Glycopeptide Antibiotics Impair Neutrophil Effector Functions

International Archives of Allergy and Immunology, 2023
Introduction: Neutrophilic granulocytes represent the first line of defense against microorganisms. Granulocytes phagocytose microorganisms and specifically synthesize oxygen radicals against them, which eventually kills the invaders. Methods: Neutrophilic granulocytes were isolated from peripheral blood of healthy volunteer donors.
Paul, Ettel, Al Nasar Ahmed, Sehgal, Nicole, Harrison, Winfried F, Pickl, Katharina, Grabmeier-Pfistershammer   +4 more
openaire   +2 more sources

Trimethoprim‐Sulfamethoxazole Activity and Pharmacodynamics against Glycopeptide‐Intermediate Staphylococcus aureus [PDF]

, 2002
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90392/1/phco.22.12.983.33599 ...
Chen, David C., Close, Sandy J., Garvin, Cory G., Martin, Steven J., McBurney, Christopher R.   +4 more
core   +1 more source

Glycopeptide antibiotics: Back to the future [PDF]

The Journal of Antibiotics, 2014
Glycopeptide antibiotics have been a key weapon in the fight against bacterial infections for over half a century, with the progenitors, vancomycin (1) and teicoplanin (2), still used extensively. The increased occurrence of resistance and the effectiveness of these 'last resort' treatments for Gram-positive infections has led to the discovery and ...
Butler, Mark S., Hansford, Karl A., Blaskovich, Mark A. T., Halai, Reena, Cooper, Matthew A.   +4 more
openaire   +3 more sources

Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]

, 2008
Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Paradis-Bleau , Catherine, Lloyd, Adrian, Sanschagrin, François, Clark, Tom, Blewett, Ann, Bugg, Tim, Levesque, Roger C.   +6 more
core   +2 more sources

Central venous catheter related infections: Risk factors and the effect of glycopeptide antibiotics

Annals of Clinical Microbiology and Antimicrobials, 2003
Backround We undertook a prospective study of all new central venous catheters inserted into patients in the intensive care units, in order to identify the risk factors and to determine the effect of glycopeptide antibiotics on catheter – related ...
Eraksoy Haluk, Çakar Nahit, Ay Pinar, Yildirim Ayşe, Özsüt Halit, Öncü Serkan, Çalangu Semra   +6 more
doaj   +1 more source

Bacterial Cell Wall Analogue Peptides Control the Oligomeric States and Activity of the Glycopeptide Antibiotic Eremomycin: Solution NMR and Antimicrobial Studies

Pharmaceuticals, 2021
For some time, glycopeptide antibiotics have been considered the last line of defense against Methicillin-resistant Staphylococcus aureus (MRSA). However, vancomycin resistance of Gram-positive bacteria is an increasingly emerging worldwide health ...
László Izsépi, Réka Erdei, Anna N. Tevyashova, Natalia E. Grammatikova, Andrey E. Shchekotikhin, Pál Herczegh, Gyula Batta   +6 more
doaj   +1 more source

Genome-scale metabolic representation of Amycolatopsis balhimycina [PDF]

, 2012
Infection caused by methicillin-resistant Staphylococcus aureus (MRSA) is an increasing societal problem. Typically, glycopeptide antibiotics are used in the treatment of these infections.
Altschul, Ayar-Kayali, Badger, Baltz, Bentley, Borodina, Caspi, Chamber, Chang, Chen, Claudel-Renard, Cole, Cvijovic, Ewing, Ewing, Finn, Fleischmann, Fleischmann, Gertz, Gordon, Gough, Gunnarsson, Haft, Henry, Kalinowski, Kanehisa, Kanehisa, Köck, Lees, Malabarba, Nadkarni, Neidhardt, Oliynyk, Olukoshi, Omura, Orth, Osterman, Patil, Pearson, Pelzer, Puk, Quevillon, Recktenwald, Rocha, Scheer, Shahab, Sigrist, Süssmuth, The Gene Ontology consortium, Thomas, Thykaer, Tian, Wink, Wohlleben, Zhao   +54 more
core   +1 more source

Antibacterial sensitizers from natural plants: A powerful weapon against methicillin-resistant Staphylococcus aureus

Frontiers in Pharmacology, 2023
Methicillin-resistant Staphylococcus aureus (MRSA) is a drug-resistant bacterium that can cause a range of infections with high morbidity and mortality, including pneumonia, etc.
Xiaoli Li, Xiaoli Li, Yongqing Cai, Qinchuan Xia, Yongqun Liao, Rongxin Qin   +5 more
doaj   +1 more source

Combinatorial Glycosylation of Glycopeptide Antibiotics [PDF]

Chemistry & Biology, 2002
The glycosyltransferases GtfE and GtfD from the vancomycin producer Amycolatopsis orientalis have promiscuous substrate and NDP-sugar specificities. They have been used to generate novel glycopeptide antibiotics containing the heptapeptide scaffolds of vancomycin and teichoplanin.
openaire   +2 more sources

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source