Results 101 to 110 of about 48,098 (265)

Pharmacokinetics of teicoplanin in paediatric patients—A systematic review of current literature

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 396-421, February 2026.
Background and Objective Teicoplanin is commonly used in children to treat gram‐positive infections and is sometimes used off‐label prophylactically in surgical or paediatric oncology settings. The pharmacokinetics (PK) of teicoplanin in children exhibit considerable variability, such as in critically ill children or those with renal impairment.
Noa E. Wijnen   +4 more
wiley   +1 more source

Characterization of core fucosylation via sequential enzymatic treatments of intact glycopeptides and mass spectrometry analysis [PDF]

open access: gold, 2022
Liwei Cao   +14 more
openalex   +1 more source

Elucidation of Proteoforms of Chinese Hamster Ovary (CHO) Phospholipase B‐Like 2 (PLBL2) Captured From a Monoclonal Antibody

open access: yesBiotechnology and Bioengineering, Volume 123, Issue 2, Page 406-419, February 2026.
A platform approach to the affinity capture and enrichment of host cell proteins to enable their subsequent deep characterization and elucidation of variants or proteoforms (e.g., molecular size variants, charge variants, glycoforms, etc.). ABSTRACT Removing host cell proteins (HCPs) during biotherapeutic manufacturing is essential to ensure patient ...
Michael E. Dolan   +6 more
wiley   +1 more source

Glycopeptide resistance among coagulase- negative staphylococci that cause bacteremia: epidemiological and clinical findings from a case-control study [PDF]

open access: yes, 2001
A 1-year prospective case-control study (ratio of control patients to case patients, 3:1) was performed to assess the incidence, risk factors, and genotypic patterns of bacteremia caused by glycopeptide-resistant coagulasenegative staphylococci (CoNS ...
Bettio, Manola   +9 more
core   +1 more source

Development and Validation of a Novel Scoring Model Integrating Clinical Risk Factors and Pharmacokinetic Parameters to Predict Vancomycin‐Induced Nephrotoxicity

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 2, February 2026.
ABSTRACT Background Vancomycin (VCM), a first‐line treatment option for infections caused by methicillin‐resistant Staphylococcus aureus, has been reported to cause nephrotoxicity even within therapeutic concentration ranges. Traditional therapeutic drug monitoring strategies rely primarily on the area under the concentration–time curve (AUC), without ...
Yoshihiko Matsuki   +6 more
wiley   +1 more source

Annotation of Peptide Structures Using SMILES and Other Chemical Codes–Practical Solutions

open access: yesMolecules, 2017
Contemporary peptide science exploits methods and tools of bioinformatics, and cheminformatics. These approaches use different languages to describe peptide structures—amino acid sequences and chemical codes (especially SMILES), respectively.
Piotr Minkiewicz   +2 more
doaj   +1 more source

Increased sialylation of site specific O-glycoforms of hemopexin in liver disease [PDF]

open access: yes, 2016
Additional file 1 . Supplemental methods, figures and tables. SM 1.1. Mapping of the O-glycosylation sites. SM 1.2. Beta elimination and mass spectrometric analysis of HPX O-glycans. Table S1.
Coleman I. Smith   +9 more
core   +2 more sources

Pharmacokinetics and Customized Dosing of Vancomycin in Adult Patients With Hematological Malignancies: Status, Challenges, and Opportunities

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
Framework diagram of CDvan informed by MCS (Eucast, European committee for antimicrobial susceptibility testing; CLSI, clinical and laboratory standard institute). ABSTRACT Vancomycin (VAN) remains the first‐line treatment for methicillin‐resistant, multidrug‐resistant gram‐positive bacterial infections, even among cancer patients.
Xiangqing Song   +3 more
wiley   +1 more source

Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations

open access: yesBeilstein Journal of Organic Chemistry, 2020
For investigations on the biological functions of oligosaccharides and peptidomimetics, new asparagine-based mono- and disaccharides containing glycopeptides were prepared in solution.
Laura Sršan, Thomas Ziegler
doaj   +1 more source

Antibiotic resistance mechanisms inform discovery: identification and characterization of a novel amycolatopsis strain producing ristocetin. [PDF]

open access: yes, 2014
Discovering new antibiotics is a major scientific challenge, made increasingly urgent by the continued development of resistance in bacterial pathogens.
Cheng, Jinhua   +5 more
core   +2 more sources

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