Results 71 to 80 of about 47,783 (272)

Human complement component C3 N-glycome changes in type 1 diabetes complications

Frontiers in Endocrinology, 2023
AimChanges in N-glycosylation have been described in numerous diseases and are being considered as biomarkers of ongoing pathological condition. Previous studies demonstrated the interrelation of N-glycosylation and type 1 diabetes (T1D), particularly ...
Dinko Šoić, Jerko Štambuk, Marko Tijardović, Toma Keser, Gordan Lauc, Gordan Lauc, Tomislav Bulum, Tomislav Bulum, Marijana Vučić Lovrenčić, Sandra Vučković Rebrina, Martina Tomić, Mislav Novokmet, Lea Smirčić-Duvnjak, Lea Smirčić-Duvnjak, Olga Gornik   +14 more
doaj   +1 more source

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research, EarlyView.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
wiley   +1 more source

Synthetic glycopeptides and glycoproteins with applications in biological research

Beilstein Journal of Organic Chemistry, 2012
Over the past few years, synthetic methods for the preparation of complex glycopeptides have been drastically improved. The need for homogenous glycopeptides and glycoproteins with defined chemical structures to study diverse biological phenomena further
Ulrika Westerlind
doaj   +1 more source

How to Dig Deeper? Improved Enrichment Methods for Mucin Core-1 Type Glycopeptides [PDF]

, 2012
Two different workflows were tested in order to develop methods that provide deeper insight into the secreted O-glycoproteome. Bovine serum samples were subjected to lectin affinity-chromatography both at the protein- and peptide-level in order to ...
Darula, Zsuzsanna, Medzihradszky F., Katalin, Sherman, J.   +2 more
core   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Solid-Phase Synthesis and Evaluation of Glycopeptide Fragments from Rat Epididymal Cysteine-Rich Secretory Protein-1 (Crisp-1) ‡

Molecules, 2010
Three 18-residue peptides with the sequence Glp-Asp-Thr-Thr-Asp-Glu-Trp-Asp-Arg-Asp-Leu-Glu-Asn-Leu-Ser-Thr-Thr-Lys, taken from the N-terminus of the rat epididymal cysteine-rich secretory protein (Crisp-1) that is important in the fertilization process,
George Barany, David W. Hamilton, Mian Liu   +2 more
doaj   +1 more source

Antimicrobials in animal agriculture: Parables and policy [PDF]

, 2015
In addition to the scientific, economic, regulatory and other policy factors that impact on antimicrobial decision-making in different jurisdictions around the world, there exist ethical, social and cultural bases for the contemporary use of these ...
Aarestrup, Aarestrup, Aarestrup, Aarestrup, Alali, Amachawadi, Bunner, Cavaco, Checkland, Cottell, Dean, Doyle, Dutil, Food and Drug Administration, Food and Drug Administration, Food and Drug Administration, Food and Drug Administration, G. H. Loneragan, G. Midgley, H. M. Scott, H. Morgan Scott, Hollway, Hurd, Hurd, Jaap A. Wagenaar, Jan, Jan, Kanwar, Kanwar, Keelara, Lowrance, Maturana, McIntosh, Midgley, Midgley, Midgley, Midgley, Platt, Popper, Ulrich, Von Foerster, Von Glasersfeld, World Health Organization, World Health Organization   +43 more
core   +1 more source

Metabolic Plasticity and Terpenoid Modulation in Zanthoxylum armatum Callus Cultures: Chemical Composition and Biotechnological Perspectives

Flavour and Fragrance Journal, EarlyView.
Graphical abstract illustrating the metabolic dynamics and regulation of terpenoid production in Zanthoxylum armatum callus cultures. On the left, callus initiation and growth from explants are shown, followed by the establishment of suspension cultures.
Sumit Purohit, Balwant Rawat, Ravendra Kumar, Mrinalini Agarwal, Somya Sinha, Shivani Negi, Namini Joshi, Akshita Raj, Prabhakar Semwal, A. Dheerani, Janhvi Mishra Rawat, Mozaniel Santana de Oliveira   +11 more
wiley   +1 more source

Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation. [PDF]

, 2018
Given that unnatural sugar expression is metabolically achieved, the kinetics and disposition of incorporation can lend insight into the temporal and localization preferences of sialylation across the cell surface.
Haigh, Nathan E, Lebrilla, Carlito B, Liu, Mingqi, Maverakis, Emanual, Park, Diane Dayoung, Phoomak, Chatchai, Wong, Maurice, Wongkham, Sopit, Xu, Gege, Yang, Pengyuan   +9 more
core  

Climate change and temperature dependent biogeography: oxygen limitation of thermal tolerance in animals [PDF]

, 2001
Recent years have shown a rise in mean global temperatures and a shift in the geographical distribution of ectothermic animals. For a cause and effect analysis the present paper discusses those physiological processes limiting thermal tolerance.
Pörtner, Hans-Otto
core   +1 more source