Results 21 to 30 of about 42,353 (227)

Absence of bleeding upon dual antiplatelet therapy in a patient with a immune GPVI deficiency

Platelets, 2021
Acquired deficiencies in platelet glycoprotein VI are rare and have not been found associated with other defects. Here we report the case of a 64-year old male patient presenting an immune GPVI deficiency associated to a mutation in the alpha-actinin ...
Stéphane Loyau Inserm, Dorothée Faille, Philippe Gautier, Paquita Nurden, Martine Jandrot-Perrus, Nadine Ajzenberg   +5 more
doaj   +1 more source

Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity

Platelets, 2021
Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP ...
Delia I. Fernández, Marijke J. E. Kuijpers, Johan W. M. Heemskerk   +2 more
doaj   +1 more source

Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member. [PDF]

PLoS ONE, 2010
LAIR-1 (Leukocyte Associated Ig-like Receptor -1) is a collagen receptor that functions as an inhibitory receptor on immune cells. It has a soluble family member, LAIR-2, that also binds collagen and can interfere with LAIR-1/collagen interactions ...
Peter J Lenting, Geertje H A Westerlaken, Cécile V Denis, Jan Willem Akkerman, Linde Meyaard   +4 more
doaj   +1 more source

Association between endometriosis, infertility and autoimmune antiplatelet glycoprotein VI antibodies in two patients

Platelets, 2023
The association between endometriosis and autoimmune diseases is well known, however no acquired platelet function defect has been described so far. We describe the case of two patients with endometriosis associated with an antiplatelet glycoprotein VI ...
Stéphane Loyau, Anne Bauters, Nathalie Trillot, Cédric Garcia, Pierre Cougoul, Hélène Pol, Camille Paris, Geoffroy Robin, Chrystèle Rubod, Bernard Payrastre, Martine Jandrot-Perrus, Sophie Voisin, Annabelle Dupont   +12 more
doaj   +1 more source

Ibrutinib-associated alveolar hemorrhage and spontaneous hemothorax

Polish Journal of Thoracic and Cardiovascular Surgery, 2022
Ibrutinib is an irreversible inhibitor of Bruton’s tyrosine kinase (BTK), a cytoplasmic tyrosine kinase of the Tec family, which plays an important role in the B-cell receptor signaling pathway [1].
Ismail Tombul, Muhammet Sayan, Nazlihan Dundar, Asena Dikyar, Seyma Yildiz, Ali Celik   +5 more
doaj   +1 more source

Co-expression of the collagen receptors leukocyte-associated immunoglobulin-like receptor-1 and glycoprotein VI on a subset of megakaryoblasts

Haematologica, 2010
Background The collagen receptor glycoprotein VI generates activating signals through an immunoreceptor tyrosine-based activating motif on the co-associated Fc receptor gamma chain.
Tessa A.M. Steevels, Geertje H.A. Westerlaken, Marloes R. Tijssen, Paul J. Coffer, Peter J. Lenting, Jan Willem N. Akkerman, Linde Meyaard   +6 more
doaj   +1 more source

The relationship between platelet glycoprotein VI T13254C polymorphism and acute myocardial infarction (MI) [PDF]

پیاورد سلامت, 2011
Background and Aim: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide. Epidemiological studies indicate that MI results from complex interactions between long-term environmental influences, concomitant disorders, and ...
A Fatemi, A Kazemi, MM Peighambari, N Givtaj, H Bakhshandeh   +4 more
doaj   +1 more source

Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation

Biomedicines, 2021
Sanguinarine, a benzophenanthridine alkaloid, has been described to have an antiplatelet activity. However, its antithrombotic effect and the mechanism of platelet inhibition have not thoroughly been explored.
Dan Shu, Ying Zhu, Meng Lu, Ao-Di He, Jiang-Bin Chen, Ding-Song Ye, Yue Liu, Xiang-Bin Zeng, Rong Ma, Zhang-Yin Ming   +9 more
doaj   +1 more source

Posttranslational modifications of platelet adhesion receptors

Pharmacological Research, 2022
Platelets play a key role in normal hemostasis, whereas pathological platelet adhesion is involved in various cardiovascular events. The underlying cause in cardiovascular events involves plaque rupture leading to subsequent platelet adhesion, activation,
Shukun Sun, Bao Qiao, Yu Han, Bailu Wang, Shujian Wei, Yuguo Chen   +5 more
doaj   +1 more source

Increased platelet reactivity as measured by plasma glycoprotein VI in gout

Platelets, 2018
Patients with gout have an increased risk of cardiovascular events. The glycoprotein VI (GPVI) receptor is found exclusively on platelets and megakaryocytes, is proteolytically cleaved upon platelet activation, and detectable in plasma as soluble GPVI ...
Richard Conway, Claire-Louise Murphy, Anne Madigan, Patricia Kavanagh, Liz Geraghty, Niamh Redmond, Laura Helbert, John J. Carey, Eimear Dunne, Dermot Kenny, Geraldine M. McCarthy   +10 more
doaj   +1 more source