PLoS Pathogens, 2023 The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates virus-cell membrane fusion.
Pantelis Poumbourios +12 more
doaj +1 more source
Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI. [PDF]
PLoS ONE, 2014 Platelets are not only central actors of hemostasis and thrombosis but also of other processes including inflammation, angiogenesis, and tissue regeneration.
Véronique Ollivier +6 more
doaj +1 more source
Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice. [PDF]
Haematologica, 2019 Wichaiyo S +9 more
europepmc +3 more sources
Evolution of replication efficiency following infection with a molecularly cloned feline immunodeficiency virus of low virulence [PDF]
, 2002 The development of an effective vaccine against human immunodeficiency virus is considered to be the most practicable means of controlling the advancing global AIDS epidemic.
Cannon, C. +7 more
core +2 more sources
Design principles for the glycoprotein quality control pathway [PDF]
, 2020 Newly-translated glycoproteins in the endoplasmic reticulum (ER) often undergo cycles of chaperone binding and release in order to assist in folding. Quality control is required to distinguish between proteins that have completed native folding, those that have yet to fold, and those that have misfolded.
arxiv +1 more source
Antibody binding reports spatial heterogeneities in cell membrane organization [PDF]
, 2022 The spatial organization of cell membrane glycoproteins and glycolipids is critical for mediating the binding of ligands, receptors, and macromolecules on the plasma membrane. However, we currently do not have the methods to quantify the spatial heterogeneities of macromolecular crowding on live cell surfaces.
arxiv +1 more source
The properties conferred upon triple-helical collagen-mimetic peptides by the presence of cysteine residues [PDF]
, 2012 Recently, the ability of polymeric collagen-like peptides to regulate cell behavior has generated great interest. A triple-helical peptide known as collagen-related peptide (CRP) contains the sequence (Gly-Pro-Hyp)10.
Bihan, Dominique G. +6 more
core +1 more source
Temperature Dependence of the Viscoelastic Properties of a Natural Gastropod Mucus by Brillouin Light Scattering Spectroscopy [PDF]
, 2023 Brillouin spectroscopy was used to probe the viscoelastic properties of a natural gastropod mucus at GHz frequencies over the range -11 $^\circ$C $\leq T \leq$ 52 $^\circ$C. Anomalies in the temperature dependence of mucus longitudinal acoustic mode peak parameters and associated viscoelastic properties at $T = -2.5^\circ$C, together with the ...
arxiv +1 more source
JACC: Basic to Translational Science, 2016 To enhance the antithrombotic properties of recombinant glycoprotein VI fragment crystallizable (GPVI-Fc), the authors incubated GPVI-Fc with anti-human Fc antibodies to cross-link the Fc tails of GPVI-Fc.
Janina Jamasbi, RPh +14 more
doaj +1 more source
Platelets at the vascular interface [PDF]
, 2018 ..
Bergmeier, Wolfgang, Stefanini, Lucia
core +1 more source