Probing Glycosaminoglycan–Protein Interactions: Applications of Surface Plasmon Resonance [PDF]
BiosensorsGlycosaminoglycans (GAGs) are highly negatively charged polysaccharides that play essential roles in numerous physiological and pathological processes through their interactions with proteins.
Changkai Bu +6 more
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Raman Investigation of Cardiac Tissues with Sodium-Induced High Stiffness [PDF]
MoleculesThis study investigates the molecular and mechanical effects of sodium accumulation in myocardial tissue using a combination of physiological measurements and Raman spectroscopy.
Igor Artyukov +6 more
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The Effect of Genipin Matrix Augmentation on the Retention of Glycosaminoglycans in the Intervertebral Disc—A Pilot Study [PDF]
BioengineeringThe degradation of intervertebral disc proteoglycans, including the loss or shortening of their hydrophilic glycosaminoglycan chains, causes a loss of disc hydration, leading to an increase in solid matrix stresses.
Thomas Hedman +2 more
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, 2021 Glycosaminoglycans (GAGs) are important constituents of human glycome. They are negatively charged unbranched polysaccharides that are usually covalently attached to proteins, forming glycan-protein conjugates, called proteoglycans. Glycosaminoglycans play critical roles in numerous biological processes throughout individual development and are also ...
Yuefan, Song +2 more
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Molecules, 2022 Glycosaminoglycans (GAGs) are a class of periodic anionic linear polysaccharides involved in a number of biologically relevant processes in the extracellular matrix via interactions with various types of molecules including proteins, peptides and small ...
Martyna Maszota-Zieleniak +2 more
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A method for characterising human intervertebral disc glycosaminoglycan disaccharides using liquid chromatography-mass spectrometry with multiple reaction monitoring [PDF]
European Cells & Materials, 2018 Intervertebral disc (IVD) degeneration results in the depletion of proteoglycans and glycosaminoglycans (GAGs), which can lead to structural and mechanical loss of IVD function, ingrowth of nociceptive nerve fibres and eventually discogenic pain ...
X Liu +7 more
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Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease β Secretase, BACE1
Marine Drugs, 2021 Only palliative therapeutic options exist for the treatment of Alzheimer’s Disease; no new successful drug candidates have been developed in over 15 years.
Courtney J. Mycroft-West +10 more
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Interactions of Pleiotrophin with a Structurally Defined Heparin Hexasaccharide
Biomolecules, 2021 Pleiotrophin (PTN) is a potent cytokine that plays an important role in neural generation, angiogenesis, inflammation, and cancers. Its interactions with the polysaccharide glycosaminoglycan (GAG) are crucial to PTN’s biological activities. In this study,
Eathen O. Ryan +3 more
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Glycosaminoglycan Modification of Decorin Depends on MMP14 Activity and Regulates Collagen Assembly
Cells, 2020 Proper processing of collagens COL1 and COL6 is required for normal function of adipose tissue and skeletal muscle. Proteoglycan decorin (DCN) regulates collagen fiber formation.
Alexes C. Daquinag +4 more
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Frontiers in Molecular Biosciences, 2020 Self-propagating form of the prion protein (PrPSc) causes many neurodegenerative diseases, such as Creutzfeldt-Jakob disease (CJD) and Gerstmann-Straussler-Scheinker syndrome (GSS).
So Young Kim +5 more
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