Results 1 to 10 of about 87,090 (247)
Glycosaminoglycan–Protein Interactions: The First Draft of the Glycosaminoglycan Interactome [PDF]
The six mammalian glycosaminoglycans (GAGs), chondroitin sulfate, dermatan sulfate, heparin, heparan sulfate, hyaluronan, and keratan sulfate, are linear polysaccharides. Except for hyaluronan, they are sulfated to various extent, and covalently attached
Sylvain D. Vallet+2 more
semanticscholar +4 more sources
PURPOSE: Development of synthetic regenerative materials inspired by the extracellular matrix (ECM) has been a topic of significant interest due to the known properties of the ECM to direct cell fate determination via tunable mate-rial composition and ...
M. Bedar+6 more
semanticscholar +1 more source
Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease
Glycosaminoglycans (GAGs) are a family of linear and negatively charged polysaccharides that exist ubiquitously on the human cell surface as well as in the extracellular matrix.
Deling Shi, Anran Sheng, Lianli Chi
semanticscholar +1 more source
Chemical Modification of Hyaluronan and Their Biomedical Applications
Hyaluronan, the extracellular matrix glycosaminoglycan, is an important structural component of many tissues playing a critical role in a variety of biological contexts.
Vera Hintze+2 more
doaj +1 more source
Effect of Glycosaminoglycan Replacement on Markers of Interstitial Cystitis In Vitro
Aims: To examine the effect of three commercial intravesical formulations of glycosaminoglycan on in vitro inflammatory models of IC/BPS to better understand there effect on specific markers of disease.Methods: Human urothelial cells (HTB-4) were ...
Peadar Rooney+8 more
doaj +1 more source
The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis
Circulating tumor cells (CTCs) are accessible by liquid biopsies via an easy blood draw. They represent not only the primary tumor site, but also potential metastatic lesions, and could thus be an attractive supplement for cancer diagnostics.
Theresa D. Ahrens+12 more
doaj +1 more source
Interactions of Pleiotrophin with a Structurally Defined Heparin Hexasaccharide
Pleiotrophin (PTN) is a potent cytokine that plays an important role in neural generation, angiogenesis, inflammation, and cancers. Its interactions with the polysaccharide glycosaminoglycan (GAG) are crucial to PTN’s biological activities. In this study,
Eathen O. Ryan+3 more
doaj +1 more source
Targeting Chemokine—Glycosaminoglycan Interactions to Inhibit Inflammation
Leukocyte migration into tissues depends on the activity of chemokines that form concentration gradients to guide leukocytes to a specific site. Interaction of chemokines with their specific G protein-coupled receptors (GPCRs) on leukocytes induces ...
Helena Crijns+2 more
semanticscholar +1 more source
Proteoglycans (PGs), present in diverse environments, such as the cell membrane surface, extracellular milieu, and intracellular granules, are fundamental to life.
Krishna Rajarathnam+3 more
doaj +1 more source
Genistein Enhances or Reduces Glycosaminoglycan Quantity in a Cell Type-Specific Manner
Background/Aims: Genistein is a natural isoflavone enriched in soybeans. It has beneficial effects for patients with mucopolysaccharidose type III through inhibiting glycosaminoglycan biosynthesis.
Ying Lan+8 more
doaj +1 more source