Results 21 to 30 of about 87,090 (247)
Mast cell glycosaminoglycans [PDF]
Glycoconjugate Journal, 2016 Mast cells contain granules packed with a mixture of proteins that are released on degranulation. The proteoglycan serglycin carries an array of glycosaminoglycan (GAG) side chains, sometimes heparin, sometimes chondroitin or dermatan sulphate. Tight packing of granule proteins is dependent on the presence of serglycin carrying these GAGs.
B. Mulloy, R. Lever, C. P. Page
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Marine Drugs, 2017 In this study, the immunomodulatory activities of Apostichopus japonicus glycosaminoglycan (AHG) on the nature killer (NK) cells, cytotoxic T lymphocytes (CTLs) and cyclophosphamide (CY)-treated mice were investigated.
Han Wang +5 more
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Keratan sulfate, a complex glycosaminoglycan with unique functional capability
Glycobiology, 2018 From an evolutionary perspective keratan sulfate (KS) is the newest glycosaminoglycan (GAG) but the least understood. KS is a sophisticated molecule with a diverse structure, and unique functional roles continue to be uncovered for this GAG.
B. Caterson, J. Melrose
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Glycosaminoglycans and Their Mimetics [PDF]
Molecules, 2016 Glycosaminoglycans (GAGs) are linear, polyanionic polysaccharides that are ubiquitous on the mammalian cell surface and in the extracellular matrix and are generally found attached to a protein core as part of a proteoglycan.[...]
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Effect of epithelial debridement on human cornea proteoglycans
Brazilian Journal of Medical and Biological Research, 2001 Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano +3 more
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mSphere, 2017 Staphylococcus aureus is a leading cause of catheter-related bloodstream infections. Biofilms form on these implants and are held together by a matrix composed of proteins, polysaccharides, and extracellular DNA (eDNA).
Surabhi Mishra, Alexander R. Horswill
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Molecules, 2020 Glycosylation is a common and widespread post-translational modification that affects a large majority of proteins. Of these, a small minority, about 20, are specifically modified by the addition of heparan sulfate, a linear polysaccharide from the ...
Thibault Annaval +5 more
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Chondrodysplasias With Multiple Dislocations Caused by Defects in Glycosaminoglycan Synthesis
Frontiers in Genetics, 2021 Chondrodysplasias with multiple dislocations form a group of severe disorders characterized by joint laxity and multiple dislocations, severe short stature of pre- and post-natal onset, hand anomalies, and/or vertebral anomalies.
Johanne Dubail +2 more
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Bioinformatics of glycosaminoglycans
Perspectives in Science, 2017 SummaryCell surface heparan sulfates modulate many signalling pathways by binding growth factors and growth factor receptors. Expressed in a spatially and temporally regulated manner, these highly sulfated polysaccharides play important roles in all aspects of animal physiology.
Han Hu +4 more
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Molecular Therapy: Methods & Clinical Development, 2017 Sanfilippo syndrome type B (mucopolysaccharidosis IIIB), caused by inherited deficiency of α-N-acetylglucosaminidase (NAGLU), required for lysosomal degradation of heparan sulfate (HS), is a pediatric neurodegenerative disorder with no approved treatment.
Mika Aoyagi-Scharber +24 more
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