Results 41 to 50 of about 154,508 (334)

A Toxoplasma gondii thioredoxin with cell adhesion and antioxidant function

Frontiers in Cellular and Infection Microbiology
BackgroundToxoplasma gondii (T. gondii) is a widespread, zoonotic protozoan intracellular parasite with a complex life cycle, which can cause toxoplasmosis, a potentially serious disease. During the invasion process, T.
Dawei Wang, Dawei Wang, Yuyi Shi, Yuyi Shi, Ziwen Cheng, Ziwen Cheng, Like Luo, Like Luo, Kuo Cheng, Kuo Cheng, Shengqi Gan, Shengqi Gan, Che Liu, Che Liu, Zeliang Chen, Baoling Yang, Baoling Yang   +16 more
doaj   +1 more source

Clearance of Heparan Sulfate and Attenuation of CNS Pathology by Intracerebroventricular BMN 250 in Sanfilippo Type B Mice

Molecular Therapy: Methods & Clinical Development, 2017
Sanfilippo syndrome type B (mucopolysaccharidosis IIIB), caused by inherited deficiency of α-N-acetylglucosaminidase (NAGLU), required for lysosomal degradation of heparan sulfate (HS), is a pediatric neurodegenerative disorder with no approved treatment.
Mika Aoyagi-Scharber, Danielle Crippen-Harmon, Roger Lawrence, Jon Vincelette, Gouri Yogalingam, Heather Prill, Bryan K. Yip, Brian Baridon, Catherine Vitelli, Amanda Lee, Olivia Gorostiza, Evan G. Adintori, Wesley C. Minto, Jeremy L. Van Vleet, Bridget Yates, Sara Rigney, Terri M. Christianson, Pascale M.N. Tiger, Melanie J. Lo, John Holtzinger, Paul A. Fitzpatrick, Jonathan H. LeBowitz, Sherry Bullens, Brett E. Crawford, Stuart Bunting   +24 more
doaj   +1 more source

Effect of Glycosaminoglycan Replacement on Markers of Interstitial Cystitis In Vitro

Frontiers in Pharmacology, 2020
Aims: To examine the effect of three commercial intravesical formulations of glycosaminoglycan on in vitro inflammatory models of IC/BPS to better understand there effect on specific markers of disease.Methods: Human urothelial cells (HTB-4) were ...
Peadar Rooney, Christina Ryan, Christina Ryan, Barry J. McDermott, Kapil Dev, Kapil Dev, Abhay Pandit, Leo R. Quinlan, Leo R. Quinlan   +8 more
doaj   +1 more source

Restoration of the Phenotype of Dedifferentiated Rabbit Chondrocytes by Sesquiterpene Farnesol

Pharmaceutics, 2022
Osteoarthritis (OA) is a joint disorder characterized by the progressive degeneration of articular cartilage. The phenotype and metabolism behavior of chondrocytes plays crucial roles in maintaining articular cartilage function.
Guan-Xuan Wu, Chun-Yu Chen, Chun-Shien Wu, Lain-Chyr Hwang, Shan-Wei Yang, Shyh-Ming Kuo   +5 more
doaj   +1 more source

Expression of transforming growth factor-beta isoforms and their receptors in chronic tendinosis [PDF]

, 2001
Chronic tendon lesions are degenerative conditions and may represent a failure to repair or remodel the extracellular matrix after repeated micro-injury.
Curry, V, Fenwick, SA, Hackney, R, Harrall, RL, Hazleman, BL, Riley, GP   +5 more
core   +2 more sources

Pleiotrophin Interaction with Synthetic Glycosaminoglycan Mimetics

Pharmaceuticals, 2022
Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo. Some structures of PTN in solution have been solved, but no precise location of the binding site has been reported yet.
Jonathan R. Miles, Xu Wang, Jose L. de Paz, Pedro M. Nieto   +3 more
doaj   +1 more source

Physical disruption of intervertebral disc promotes cell clustering and a degenerative phenotype [PDF]

, 2019
© 2019, The Author(s). To test the hypothesis that physical disruption of an intervertebral disc disturbs cell-matrix binding, leading to cell clustering and increased expression of matrix degrading enzymes that contribute towards degenerative disc cell ...
Adams, M.A., Claireaux, H., Dolan, T., Flower, L., Harding, I.J., Lama, P., Le Maitre, Christine   +6 more
core   +1 more source

Glycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System

Pharmaceuticals, 2017
Chemokines have two types of interactions that function cooperatively to control cell migration. Chemokine receptors on migrating cells integrate signals initiated upon chemokine binding to promote cell movement.
A. Proudfoot, Z. Johnson, Pauline Bonvin, T. Handel   +3 more
semanticscholar   +1 more source

Dengue virus infection induces complement factor H but protein remains cell-associated, with changes intracellularly and in cell surface binding

Exploration of Immunology
Aim: Severe dengue is correlated with a decrease in the circulating complement regulator, factor H (FH) and prior work has shown that dengue virus (DENV) infection induces FH mRNA but not FH protein release.
Joshua G. Dubowsky, Binoy Appukuttan, Evangeline Cowell, Valeria Sanders, David L. Gordon, Jillian M. Carr   +5 more
doaj   +1 more source

Glycosaminoglycans as Biomarkers for Mucopolysaccharidoses and Other Disorders

Diagnostics, 2021
Glycosaminoglycans (GAGs) are present in proteoglycans, which play critical physiological roles in various tissues. They are known to be elevated in mucopolysaccharidoses (MPS), a group of rare inherited metabolic diseases in which the lysosomal enzyme ...
Paige C. Amendum, Shaukat Khan, Seiji Yamaguchi, Hironori Kobayashi, Yasuhiko Ago, Yasuyuki Suzuki, Betul Celik, Estera Rintz, Jobayer Hossain, Wendi Xiao, Shunji Tomatsu   +10 more
doaj   +1 more source