Results 61 to 70 of about 116,862 (285)

Knee crepitus and osteoarthritis features in young adults following traumatic knee injury

Arthritis Care &Research, Accepted Article.
Objective This study explored the association between knee crepitus and the presence, and worsening, of structural osteoarthritis features and self‐reported outcomes in young adults following traumatic knee injury. Methods One‐year following anterior cruciate ligament reconstruction (ACLR), 112 participants (41 female participants; median age 28 years)
Jamon L Couch, Brooke E Patterson, Kay M Crossley, Ali Guermazi, Matthew G King, Danilo De Oliveira Silva, Jackie L Whittaker, Michael A Girdwood, Adam G Culvenor   +8 more
wiley   +1 more source

BMP2 and TGF-β Cooperate Differently during Synovial-Derived Stem-Cell Chondrogenesis in a Dexamethasone-Dependent Manner [PDF]

, 2019
Recent studies highlighting mesenchymal stem cell (MSC) epigenetic memory suggest that a different differentiation medium may be required depending on the tissue of origin.
Alini, Mauro, Basoli, Valentina, Della Bella, Elena, Kovermann, Nikolas J., Kubosch, Eva Johanna, Lischer, Christoph, Schmal, Hagen, Stoddart, Martin J.   +7 more
core   +1 more source

The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization

Advanced Biology, EarlyView.
This study explores the use of collagen‐hyaluronic acid (HA) hydrogels for the 3D culture of macrophages, providing a useful tool for modelling macrophage behavior in tissues and diseases. It highlights how hydrogel composition, mechanical properties, and preparation methods influence macrophage behavior, revealing for the first time that HA's ...
Tiah CL Oates, Jasmin Boyd, Louise Dolan, C de Kergariou, Jingwen Zhu, Ash Toye, Adam W Perriman, Asme Boussahel   +7 more
wiley   +1 more source

A Toxoplasma gondii thioredoxin with cell adhesion and antioxidant function

Frontiers in Cellular and Infection Microbiology
BackgroundToxoplasma gondii (T. gondii) is a widespread, zoonotic protozoan intracellular parasite with a complex life cycle, which can cause toxoplasmosis, a potentially serious disease. During the invasion process, T.
Dawei Wang, Dawei Wang, Yuyi Shi, Yuyi Shi, Ziwen Cheng, Ziwen Cheng, Like Luo, Like Luo, Kuo Cheng, Kuo Cheng, Shengqi Gan, Shengqi Gan, Che Liu, Che Liu, Zeliang Chen, Baoling Yang, Baoling Yang   +16 more
doaj   +1 more source

Immunoenhancement Effects of Glycosaminoglycan from Apostichopus japonicus: In Vitro and In Cyclophosphamide-Induced Immunosuppressed Mice Studies

Marine Drugs, 2017
In this study, the immunomodulatory activities of Apostichopus japonicus glycosaminoglycan (AHG) on the nature killer (NK) cells, cytotoxic T lymphocytes (CTLs) and cyclophosphamide (CY)-treated mice were investigated.
Han Wang, Shuang Yang, Yuanhong Wang, Tingfu Jiang, Shuai Li, Zhihua Lv   +5 more
doaj   +1 more source

Home treatment of type VI mucopolysaccharidosis (Maroteaux‐Lamy syndrome) an alternative at this time of COVID‐19 pandemic: A case in Peru

Clinical Case Reports, 2020
We report a patient with mucopolysaccharidosis type VI, on long‐term enzyme replacement home therapy. Results support the efficacy and safety benefits, with additional advantage of home therapy to minimize the risk of community‐transmitted infections.
Jenny Lucy Cortez Miranda, Lincoln Blacido Trujillo, María Elena Liendo Chocano   +2 more
doaj   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Cant1 Affects Cartilage Proteoglycan Properties: Aggrecan and Decorin Characterization in a Mouse Model of Desbuquois Dysplasia Type 1

Biomolecules
Desbuquois dysplasia type 1 (DBQD1) is a recessive chondrodysplasia caused by mutations in the CANT1 gene, encoding for the Golgi Calcium-Activated Nucleotidase 1 (CANT1). The enzyme hydrolyzes UDP, the by-product of glycosyltransferase reactions, but it
Chiara Gramegna Tota, Alessandra Leone, Asifa Khan, Antonella Forlino, Antonio Rossi, Chiara Paganini   +5 more
doaj   +1 more source

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

Advanced Functional Materials, EarlyView.
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo, Chiara Arrigoni, Tobias Faehling, Antonietta Verrillo, Viviana Secci, Thomas G. P. Grünewald, Giuseppe Talò, Alexandra Kummer, Jorge Gonzalez, Vincenzo De Rosa, Christian Candrian, Andrea Barbero, Florencia Cidre‐Aranaz, Matteo Moretti   +13 more
wiley   +1 more source

Targeting of Glycosaminoglycans in Genetic and Inflammatory Airway Disease [PDF]

, 2022
Robin Caird, Michael Williamson, A. O. Yusuf, Debananda Gogoi, Michelle Casey, Noel G. McElvaney, Emer P. Reeves   +6 more
openalex   +1 more source