Results 71 to 80 of about 87,090 (247)
Marine Drugs, 2019 Therapeutic options for Alzheimer’s disease, the most common form of dementia, are currently restricted to palliative treatments. The glycosaminoglycan heparin, widely used as a clinical anticoagulant, has previously been shown to inhibit the ...
Courtney J. Mycroft-West +9 more
doaj +1 more source
Journal of Biological Chemistry, 2014 Background: The enzyme responsible for the dephosphorylation of xylose in glycosaminoglycans remains unknown. Results: A protein that removed the phosphate from the phosphorylated linkage trisaccharide and localized in the Golgi was identified ...
Toshiyasu Koike +3 more
semanticscholar +1 more source
Regulation of proBACE1 by Glycosaminoglycans [PDF]
Neurodegenerative Diseases, 2008 The β-secretase (BACE1) is initially synthesized as a partially active zymogen containing a prodomain which can be further activated through proteolytic cleavage of the prodomain by a furin-like protease. The active site of BACE1 is large and although a number of high-affinity active-site inhibitors of BACE1 have been described, most of these compounds
David W Klaver +2 more
openaire +3 more sources
Glycosaminoglycans in patellar cartilage [PDF]
Acta Orthopaedica Scandinavica, 1989 We obtained samples of patellar cartilage at the time of surgery from 20 patients: 11 with normal and 9 with macroscopic cartilaginous degeneration. The glycosaminoglycans were separated by cellulose acetate electrophoresis, and the relative content of major glycosaminoglycans was measured by optic scanning.
Trier K, Møller H, Olsen Eb
openaire +3 more sources
High-Value Components and Bioactives from Sea Cucumbers for Functional Foods—A Review
Marine Drugs, 2011 Sea cucumbers, belonging to the class Holothuroidea, are marine invertebrates, habitually found in the benthic areas and deep seas across the world. They have high commercial value coupled with increasing global production and trade.
Nazamid Saari +2 more
doaj +1 more source
Sulfated Glycosaminoglycans as Viral Decoy Receptors for Human Adenovirus Type 37
Viruses, 2019 Glycans on plasma membranes and in secretions play important roles in infection by many viruses. Species D human adenovirus type 37 (HAdV-D37) is a major cause of epidemic keratoconjunctivitis (EKC) and infects target cells by interacting with sialic ...
Naresh Chandra +10 more
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Establishment of Glycosaminoglycan Assays for Mucopolysaccharidoses
Metabolites, 2014 Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders caused by deficiency of the lysosomal enzymes essential for catabolism of glycosaminoglycans (GAGs).
S. Tomatsu +13 more
semanticscholar +1 more source
Cell Reports, 2016 The basement membrane is crucial for cell polarity, adhesion, and motility, but how it is assembled on the cell surface remains unclear. Here, we find that ablation of glycosaminoglycan (GAG) side chains of proteoglycans in the neuroretina disrupts the ...
Chenqi Tao, Xin Zhang
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A Tunable Glycosaminoglycan–Peptide Nanoparticle Platform for the Protection of Therapeutic Peptides
PharmaceuticsThe popularity of Glycosaminoglycans (GAGs) in drug delivery systems has grown as their innate ability to sequester and release charged molecules makes them adept in the controlled release of therapeutics.
Harkanwalpreet Sodhi, Alyssa Panitch
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Galactosaminoglycans from normal myometrium and leiomyoma
Brazilian Journal of Medical and Biological Research, 2001 In many tumors, the amount of chondroitin sulfate in the extracellular matrix has been shown to be elevated when compared to the corresponding normal tissue. Nevertheless, the degree of chondroitin sulfate increase varies widely.
A.G.A. Berto +3 more
doaj +1 more source