Results 251 to 260 of about 98,029 (348)

The role of glycosaminoglycans in vascular stiffness and non-osmotic sodium storage

, 2018
Kathleen Connolly
openalex   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Spatial Profiling of Glycosaminoglycans (GAGomics) From Laser Microdissected Mouse Brain. [PDF]

Mol Cell Proteomics
Mernie E, Zaia J.
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Protamine Drives Liquid and Solid Condensation of DNA and Glycosaminoglycans. [PDF]

Langmuir
van der Harten FJF, Sheikhhassani V, Mashaghi A.   +2 more
europepmc   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Change in the chondroitin/dermatan structure in distal lung tissue from COPD patients. [PDF]

Sci Rep
Alsafadi HN, Nybom A, Wagner D, Malmström A, Lindstedt S, Bjermer L, Dellgren G, Malmström J, Tykesson E, Westergren-Thorsson G, Hallgren O.   +10 more
europepmc   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Critical evaluation of compositions and clinical relevance of Wharton's jelly-derived biologics. [PDF]

J Transl Med
Marleau AM, Pearl JR, Juarez P, Almeida P, Miguel S, Olvera Felix E, Marincola FM, West R, Howard L, Guerena D, Clay E.   +10 more
europepmc   +1 more source

A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds

, 2006
Eric Farrell, Elaine Byrne, Jan Fischer, Fergal J. O’Brien, Brian O’Connell, P.J. Prendergast, Veronica A. Campbell   +6 more
openalex   +2 more sources