Results 291 to 300 of about 88,369 (330)
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Glycosaminoglycans and Neuroprotection
2011Glycosaminoglycans (GAGs) are basic building blocks of the ground substance of the extracellular matrix and present at the cellular level as an important component of the glycocalyx covering the cell membrane. In addition to the general role of GAGs in maintaining the integrity of the cell and extracellular matrix by retaining water, certain GAGs ...
B, Dudas, K, Semeniken
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Serpin–Glycosaminoglycan Interactions
2011Serpins (serine protease inhibitors) have traditionally been grouped together based on structural homology. They share common structural features of primary sequence, but not all serpins require binding to cofactors in order to achieve maximal protease inhibition. In order to obtain physiologically relevant rates of inhibition of target proteases, some
Chantelle M, Rein +2 more
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Glycosaminoglycans in Neurofibromas
The Journal of Dermatology, 1990AbstractGlycosaminoglycan (GAG) contents in neurofibromas (NFs) were examined to clarify how well they corresponded to their histological features. Eight cutaneous NFs and three plexiform NFs from five patients with Recklinghausen's (R) disease, two senile NFs, and control dermis were subjected to the isolation of GAGs.
T, Sasaki, S, Onodera
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Glycosaminoglycans in Urolithiasis
Nephron, 1992To determine if there are differences in urinary glycosaminoglycan (GAG) concentrations, 43 stone-forming patients and 37 healthy control subjects of both sexes were studied. Urinary concentrations of calcium, magnesium, creatinine, uric acid and GAGs were determined.
A, Nesse +4 more
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Brain glycosaminoglycans and glycosaminoglycan sulphotransferase in sanfilippo syndrome
Clinica Chimica Acta, 1970Analysis of various glycosaminoglycans in brain obtained from two patients with Sanfilippo syndrome indicates that the major glycosaminoglycan accumulated in brain was heparan sulphate. Dermatan sulphate was also increased in one case as compared to normal, whereas only heparan sulphate was present in the other. Chondroitin-4-sulphate sulphotransferase
E, George, B K, Bachhawat
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Glycosaminoglycans: Clinical Use
Seminars in Thrombosis and Hemostasis, 1996Heparins, dermatan sulfate (DS), and Orgaran are the only glycosaminoglycans that have been used as antithrombotic agents in man. The largest experience concerns unfractionated heparin (UH) and its low-molecular-weight derivatives (LMWHs). It is firmly established that UH is efficient and safe in the prevention and treatment of deep vein thrombosis ...
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Biochimica et Biophysica Acta, 1986
R. Farndale, D. Buttle, A. J. Barrett
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R. Farndale, D. Buttle, A. J. Barrett
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Therapeutic Applications of Glycosaminoglycans
Current Medicinal Chemistry, 2006Complex polysaccharides, hyaluronic acid or hyaluronan (HA), keratan sulfate (KS), chondroitin sulfates (CSs) and heparin (Hep)/heparan sulfate (HS), are a class of ubiquitous molecules exhibiting a wide range of biological functions. They are widely distributed as glycosaminoglycans (GAGs) sidechains of proteoglycans (PGs) in the extracellular matrix ...
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Sulfation of Glycosaminoglycans and Its Implications in Human Health and Disorders.
Annual Review of Biomedical Engineering, 2017D. Soares da Costa +2 more
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The GAGOme: a cell-based library of displayed glycosaminoglycans
Nature Methods, 2018Yen-Hsi Chen +16 more
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