Results 41 to 50 of about 16,712 (156)
Molecules, 2022 Bambusurils, BU[4] and BU[6], were used for the first time as multivalent scaffolds to link glycosidases inhibitors derived from 1-deoxynojirimycin (DNJ).
Marine Lafosse +6 more
doaj +1 more source
Annona muricata (graviola): toxic or therapeutic [PDF]
, 2008 This paper examines annona muricata (graviola): toxic or ...
Gray, A.I. +7 more
core
Characterization of the interdependency between residues that bind the substrate in a β-glycosidase [PDF]
, 2010 The manner by which effects of simultaneous mutations combine to change enzymatic activity is not easily predictable because these effects are not always additive in a linear manner. Hence, the characterization of the effects of simultaneous mutations of
GONÇALVES, L.M. +3 more
core +3 more sources
Protecting-Group-Free Synthesis of 2-Deoxy-Aza-Sugars
Molecules, 2009 The protecting-group-free asymmetric synthesis of 1,2,4-trideoxy-1,4-imino-L-xylitol is readily achieved in five steps from 2-deoxy-D-ribose and with an overall yield of 48%.
Mattie Simon Maria Timmer +3 more
doaj +1 more source
Inhibitors of the Cellular Trafficking of Ricin
Toxins, 2012 Throughout the last decade, efforts to identify and develop effective inhibitors of the ricin toxin have focused on targeting its N-glycosidase activity.
Daniel Gillet +3 more
doaj +1 more source
Microwave-Assisted Synthesis of Andrographolide Analogues as Potent β-Glycosidase Inhibitors
SynOpen, 2018 Andrographolide, a bioactive compound isolated from Andrographis paniculata exhibits multiple pharmacological activities, including anti-HIV, antiplatelet aggregation, hepatic lipid peroxidation protective, hepatoprotective, choleretic, and anticancer ...
Masood ur Rahman +4 more
doaj +1 more source
3-Hydroxypyrrolidine and (3,4)-dihydroxypyrrolidine derivatives: inhibition of rat intestinal α-glucosidase [PDF]
, 2014 Thirteen pyrrolidine-based iminosugar derivatives have been synthesized and evaluated for inhibition of α-glucosidase from rat intestine. The compounds studied were the non-hydroxy, mono-hydroxy and dihydroxypyrrolidines.
Adriano, Gizé +8 more
core +1 more source
Biomedicines, 2021 During a search for glycosidase inhibitors among marine natural products, we applied an integrated in vitro and in silico approach to evaluate the potency of some aaptamines and makaluvamines isolated from marine sponges on the hydrolyzing activity of α ...
Natalia Utkina +6 more
doaj +1 more source
Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases [PDF]
, 2016 Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native folding and impair the trafficking of enzymes, leading to premature endoplasmic reticulum (ER)-associated degradation, deficiencies of specific hydrolytic functions ...
García-Fernández, José Manuel +2 more
core +1 more source
General Intermediates for the Synthesis of 6-C-Alkylated DMDP-Related Natural Products
Molecules, 2013 Protected L-homoDMDP en-8 and its C-6 epimer en-7 were prepared through two different pathways starting from the vinylpyrrolidine en-9. Based on the NMR and X-ray analysis, the stereochemistry of homoDMDP at C-6 was confirmed to be consistent with ...
Chu-Yi Yu +3 more
doaj +1 more source