Results 51 to 60 of about 665,601 (180)

Convergent, stereoselective syntheses of the glycosidase inhibitors broussonetines D and M [PDF]

, 2009
The first syntheses of the polyhydroxylated alkaloids (iminosugars) broussonetines D and M glycosidase inhibitors of the pyrrolidine class, have been performed in a convergent, stereocontrolled way from D-serine as the chiral starting material. A cross
Falomir, Eva, Murga, Juan, Ribés Vidal, Celia, Marco, J. Alberto, Carda, Miguel, Celia Ribes, Miguel Carda, Juan Murga, J. Alberto Marco, Eva Falomir   +9 more
core   +1 more source

General Intermediates for the Synthesis of 6-C-Alkylated DMDP-Related Natural Products

Molecules, 2013
Protected L-homoDMDP en-8 and its C-6 epimer en-7 were prepared through two different pathways starting from the vinylpyrrolidine en-9. Based on the NMR and X-ray analysis, the stereochemistry of homoDMDP at C-6 was confirmed to be consistent with ...
Chu-Yi Yu, Yue-Mei Jia, Yi-Xian Li, Mu-Hua Huang   +3 more
doaj   +1 more source

Fluorinated Iminosugar Glycomimetics: Synthesis and Activity as GCase Ligands

European Journal of Organic Chemistry, EarlyView.
DAST‐mediated deoxyfluorination of suitably functionalized piperidines provided regio‐ and stereoselective access to fluorinated piperidine and pyrrolidine glycomimetics, the latter arising from an unusual ring‐contraction process. Fluorination generally enhanced β‐glucocerebrosidase (GCase) inhibitory potency, but lost PC activity toward L444P/L444P ...
Francesca Mangiavacchi, Alessio Morano, Cosimo Margheri, Cristina Faggi, Amelia Morrone, Camilla Matassini, Francesca Clemente, Andrea Goti, Martina Cacciarini, Francesca Cardona   +9 more
wiley   +1 more source

Synthesis of hybrids of D-glucose and D-galactose with pyrrolidine-based iminosugars as glycosidase inhibitors

, 2008
Sugar-iminosugar hybrid molecules made up of D-glucose and D-galactose with pyrrolidine-based iminosugars, viz. 1,4-dideoxy-1,4-imino-L-xylitol and 1,4-dideoxy-1,4-imino-L-lyxitol, are synthesized from glycal epoxides and found to be moderate glycosidase
Basak, Ranjan K., Kokatla, Hari Prasad, John Pal, A. P., Vankar, Yashwant D., Doddi, Venkata Ramana   +4 more
core   +1 more source

Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors

Molecules, 2019
A series of simple C-alkyl pyrrolidines already known as cytotoxic inhibitors of ceramide glucosylation in melanoma cells can be converted into their corresponding 6-membered analogues by means of a simple ring expansion.
Cécile Baudoin-Dehoux, Tessa Castellan, Frédéric Rodriguez, Arnaud Rives, Fabien Stauffert, Virginie Garcia, Thierry Levade, Philippe Compain, Yves Génisson   +8 more
doaj   +1 more source

Correlations Among Glycemia and Glucose Variability, Thyroid Hormones, and Albuminuria in Patients With Type 2 Diabetes Mellitus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hyperglycemia, glucose fluctuations, and thyroid dysfunction contribute to the progression of diabetic nephropathy. This study aimed to investigate the associations of glycemia, glucose variability, and thyroid hormones with albuminuria in patients with type 2 diabetes mellitus (T2DM). In total, 451 T2DM patients were included.
Na Luo, Shang‐Yong Feng, Hui Chen, Dun‐Min She, Yan Liu, Ying Li, Cai‐Feng Yan, Zhen‐Wen Zhang, Jing Chen, Xiao‐Li Cai, Gao‐Yu Zhao, Hui Yu, Yan Wang   +12 more
wiley   +1 more source

The Interaction of Anhydroalditols with Sweet-Almond β-glucosidase and Escherichia coli β-galactosidase: implications for the design of potent glycosidase inhibitors

, 1991
A range of 1,4- and 1,5-anhydroalditols have been synthesized and assessed for their ability to inhibit glycosidases. Observed inhibition indicates that aglycone-enzyme interactions contribute significantly to both the affinity and the stereoselectivity ...
Field, Robert A., Haines, Alan H., Chrystal, Ewan J. T., Chrystal, E.J.T., Haines, A.H., Field, R.A.; id_orcid, Alan H. Haines, Robert A. Field, Ewan J.T. Chrystal   +8 more
core   +1 more source

Regioselectivity in the Ring Opening of Epoxides for the Synthesis of Aminocyclitols from D-(-)-Quinic Acid

Molecules, 2012
Efficient syntheses of four aminocyclitols are reported. Each synthesis is accomplished in eight steps starting from D-(-)-quinic acid. The key step involves a highly regioselective ring opening of epoxides by sodium azide.
Shu-Yu Yang, Tzenge-Lien Shih
doaj   +1 more source

Effects of Composite Reclamation Models of Sea Buckthorn, A Pioneer Species in Semi‐Arid Regions, on Soil Quality and Microbial Communities

Land Degradation &Development, EarlyView.
ABSTRACT Open‐pit coal mining severely degrades soil and ecosystem functions, constraining regional sustainability. Vegetation‐based reclamation has therefore been widely adopted as an effective approach to promote soil recovery and ecosystem restoration.
Bo Wen, Yun Li, Haixin Yang, Pengjie Guo, Donggang Guo, Yu Lin, Xianyun Zheng, Quanxi Zhang   +7 more
wiley   +1 more source

Transition-State Mimicry by Glycosidase Inhibitors:  A Critical Kinetic Analysis

, 2016
A considerable effort has been invested in the design and synthesis of transition-state analogue inhibitors of glycosidases, particularly with respect to their potential as therapeutics.
Spencer J. Williams (180548), Stephen G. Withers (1316403), Jacqueline Wicki (719781)   +2 more
core   +1 more source