Results 71 to 80 of about 665,601 (180)

Benign by design: A paradigm shift in cosmetic ingredient development

International Journal of Cosmetic Science, EarlyView.
Benign by design strategies enable the creation of biodegradable cosmetic ingredients, reducing environmental persistence while maintaining the intended biological activity. This work compiles design rules and tools to guide the development of more sustainable molecules for the cosmetics industry.
Sandra Mota, Klaus Kümmerer, Isabel Martins de Almeida, Emília Sousa   +3 more
wiley   +1 more source

1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor [PDF]

, 2017
The essential biological roles played by glycosidases, coupled to the diverse therapeutic benefits of pharmacologically targeting these enzymes, provide considerable motivation for the development of new inhibitor classes.
Breen, I.Z., Ferraz, Maria J., Kuo, C.L., Van Der Marel, Gijsbert A., Aerts, J.M.F.G., Carme Rovira, Codee, J.D.C., Codée, Jeroen D.C., Wu, Liang, Johannes M. F. G. Aerts, Chi-Lin Kuo, Imogen Z. Breen, Davies, Gideon J., Marta Artola, Maria J. Ferraz, Raich, L., Marel, G.A. van der, Rovira, C., Overkleeft, H.S., Jeroen D. C. Codée, Gideon J. Davies, Davies, G.J., Raich, Lluís, Rovira, Carme, Liang Wu, Artola Perez de Azanza, M.E., Breen, Imogen Z., Gijsbert A. van der Marel, Wu, L., Offen, W.A., Overkleeft, Herman S., Artola, Marta, Guimaraes Da Lomba Ferraz, M.J., Aerts, Johannes M.F.G., Herman S. Overkleeft, Kuo, Chi Lin, Offen, Wendy A., Lluís Raich, Wendy A. Offen   +38 more
core   +1 more source

Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors

, 2023
International audienceCapitalizing on a previously developed Staudinger/azaWittig/Grignard (SAWG)-ring contraction sequence that furnished protected six-membered L-iminosugar C,C-glycosides bearing an allyl group and various substituents at the ...
Désiré, Jérôme, Debbah, Zakaria, Atsushi Kato, Jérôme Désiré, Marrot, Jérôme, Zakaria Debbah, Blériot, Yves, Jérôme Marrot, Gueyrard, David, Kato, Atsushi, David Gueyrard, Yves Blériot   +11 more
core   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Serum‐derived microribonucleic acids as potential novel biomarkers for slowly progressive type 1 diabetes mellitus

Journal of Diabetes Investigation, EarlyView.
This study evaluated serum miRNAs as biomarkers in adult patients with SPIDDM. Serum miRNAs were measured at the time of SPIDDM (probable) diagnosis, and miR‐150‐5p was inversely associated with CPI at the last outpatient visit, suggesting its potential utility for predicting subsequent insulin secretory decline.
Hideyuki Okuma, Takahiro Tsutsumi, Masashi Ichijo, Tetsuro Kobayashi, Kyoichiro Tsuchiya   +4 more
wiley   +1 more source

Studies into the Stereo Selective Synthesis of Glycosidase Inhibitors.

, 2004
The goal of our research was to develop an enantiopure glycosidase inhibitor. Glycosidase inhibitors are similar in structure to sugar molecules, and therefore lock up enzymes used in the consumption of sugars for respiration.
Vachher-Gnanathurai, Amit
core  

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3079-3105, November 2026.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Flexible Enantiodivergent Synthesis and Biological Activity of Mannostatin Analogues, New Cyclitol Glycosidase Inhibitors

, 2016
Mannostatin A (1) is a new cyclitol inhibitor of glycoprotein processing. 2-Epimannostatin A (12) and its enantiomer (13) as well as their positional isomers (14, 15) were designed for probing structure−activity relationships in this class of ...
Hayamitsu Adachi (1666837), Shinichi Kondo (2995791), Yoshio Nishimura (1965370), Yoji Umezawa (2455222), Tomio Takeuchi (2995788)   +4 more
core   +2 more sources

A novel CAV derived cell-penetrating peptide efficiently delivers exogenous molecules through caveolae-mediated endocytosis

Veterinary Research, 2018
Cell-penetrating peptide (CPP) is a promising cargo for delivering bioactive molecules. In this study, the N terminus of VP1 from chicken anemia virus, designated as CVP1, was found to carry enriched arginine residues with α-helix.
Gaowei Hu, Wenlv Zheng, Ao Li, Yaru Mu, Mingyu Shi, Tuofan Li, Haitao Zou, Hongxia Shao, Aijian Qin, Jianqiang Ye   +9 more
doaj   +1 more source

Precision Profiling of α‐1,4‐ Versus α‐1,6‐Glycosidase Activity Through Synthetic Linear and Branched Glycogen Tetramers Using Cyclic Ion Mobility Mass Spectrometry and High‐Performance Liquid Chromatography‐Mass Spectrometry

ChemistryEurope, Volume 4, Issue 11, November 2026.
Synthesis of glycogen‐like tetrasaccharides allowed the design of an integrated HILIC‐MS/cyclic ion mobility MS workflow to characterize glycosidase specificity. HsGDE selectively hydrolyzed α‐1,6 branches, whereas yeast α‐1,4‐glucosidase preferentially cleaved α‐1,4 linkages, and the rice enzyme showed broader regioisomeric activity.
Delphine Carry, Ruben Ananian, Zineb Chaabi, Estelle Messé, Georg Niggemeyer, Benoit Keromnes, Jean‐François Gallard, Cédric Przybylski, Peter H. Seeberger, Christian Roth, Salomé Poyer, Stéphanie Norsikian, Sébastien Vidal   +12 more
wiley   +1 more source