Results 81 to 90 of about 665,601 (180)

Aminocyclopentanols - Potential glycosidase inhibitors

, 2003
Recently several aminocyclopentanols having the aminogroup adjacent to a carbon sidechain, proved to be potent and anomer-selective glycosidase inhibitors.1 The bicyclic lactone 1, which has been synthesised in our group from sugar-derived starting ...
Lauritsen, Marie
core  

Monosaccharide and Disaccharide Mimics: New Molecular Tools for Biology and Medicine

CHIMIA, 2001
Intercellular communication is governed by interactions between surface oligosaccharides and glycoproteins. The biosynthesis of these molecules involves glycosidations catalyzed by glycosyltransferases and hydrolysis of O-glycosyl linkages ...
Pierre Vogel
doaj  

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1338-1347, November 2026.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

High Throughput Approaches in Carbohydrate‐Active Enzymology: Glycosidase and Glycosyl Transferase Inhibitors, Evolution, and Discovery

, 2019
This is the pre-peer reviewed version of the following article: "High Throughput Approaches in Carbohydrate‐Active Enzymology: Glycosidase and Glycosyl Transferase Inhibitors, Evolution, and Discovery", which has been accepted for publication and ...
Seino Jongkees, Chao, Lemeng, Lemeng Chao, Jongkees, Seino A. K.   +3 more
core   +1 more source

General Method for the Synthesis of (−)-Conduritol C and Analogs from Chiral Cyclohexadienediol Scaffolds

Molecules, 2018
An efficient and facile general method for the synthesis of conduritol C analogs, taking advantage of an enantioselective biocatalysis process of monosubstituted benzenes, is described. The absolute stereochemical patterns of the target molecules (−
Gaurao D. Tibhe, Mario A. Macías, Valeria Schapiro, Leopoldo Suescun, Enrique Pandolfi   +4 more
doaj   +1 more source

Structure based virtual screening of natural product molecules as glycosidase inhibitors. [PDF]

In Silico Pharmacol, 2021
Moorthy NSHN, Brás NF, Ramos MJ, Fernandes PA.   +3 more
europepmc   +1 more source

Plant‐Derived Probiotics From Fermented Foods: Current Evidence on Antiviral Mechanisms and Gut–Lung Axis Modulation

Food Frontiers, Volume 7, Issue 6, November 2026.
Plant‐derived probiotics from fermented foods exert anti‐respiratory virus effects via immune regulation, antiviral metabolites, and gut–lung axis, highlighting their advantages, key technologies, and application prospects. ABSTRACT Respiratory viral infections represent a major global public health threat, causing widespread morbidity, mortality, and ...
Yinghao Xing, Yaoyuan Hu, Yingying Ma, Peng Yao, Jingjing Jiang, Jiao Guo, Shuangmei Liu   +6 more
wiley   +1 more source

Stereoselective syntheses of the glycosidase inhibitors hyacinthacine A2, hyacinthacine A3 and 5-epi-hyacinthacine A3

, 2009
Stereoselective syntheses of the naturally occurring glycosidase inhibitors hyacinthacines A2 and A3 are reported. In the case of hyacinthacine A2, the pyrrolizidine system was created from an acyclic precursor via a double cyclization procedure with a ...
Falomir, Eva, Ribés Vidal, Celia, Marco, J. Alberto, Carda, Miguel, Celia Ribes, Miguel Carda, J. Alberto Marco, Eva Falomir   +7 more
core   +1 more source

Some pyrazoles derivatives: Potent carbonic anhydrase, -glycosidase, and cholinesterase enzymes inhibitors [PDF]

, 2018
WOS: 000446308600005PubMed: 30246264A series of substituteed pyrazol-4-yl-diazene derivatives were found to be effective inhibitors against -glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), butyrylcholinesterase (BChE), and ...
Taslimi, Parham, İlhami Gulçin, Fikret Turkan, Gulcin, Ilhami, Turkan, Fikret, Turkan, F., Adnan Cetin, Cetin, Adnan, Gulçin, İ., Taslimi, P., Cetin, A., Parham Taslimi, Gulçin İ.   +12 more
core   +1 more source

Design and synthesis of biologically active carbaglycosylamines: From glycosidase inhibitors to pharmacological chaperones. [PDF]

Proc Jpn Acad Ser B Phys Biol Sci, 2022
Ogawa S, Kuno S, Toyokuni T.
europepmc   +1 more source