Results 101 to 110 of about 665,601 (180)
Targeting Selectivity: Improving Golgi α-Mannosidase II (GMII) Inhibitors Through In Silico Studies
BiomoleculesAberrant glycosylation is a recognized hallmark of cancer, establishing Golgi α-mannosidase II (GMII) as strategic therapeutic target. While the natural alkaloid swainsonine demonstrated potent anticancer activity, its clinical use is hampered by ...
Nieves G. Ledesma +4 more
doaj +1 more source
Synthesis and evaluation of hydroxymethylaminocyclitols as glycosidase inhibitors [PDF]
, 2015 Four series of C7N aminocyclitol analogues of glucose were synthesized by stereocontrolled epoxide opening of hydroxyl protected forms of the cyclohexane epoxides cyclophellitol and 1,6-epi-cyclophellitol.
Egido-Gabás, Meritxell +11 more
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, 2018 In this paper, we investigated the hypothesis that pseudouridine isoxazolidinyl nucleoside analogues could act as potential inhibitors of the pseudouridine 5ʹ-monophosphate glycosidase. This purpose was pursued using molecular modeling and in silico ADME-
Damigella Arcangelo +8 more
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Acarbose versus trans-chalcone: comparing the effect of two glycosidase inhibitors on obese mice
Archives of Endocrinology and MetabolismObjective Acarbose and trans-chalcone are glucosidase inhibitors whose beneficial effects have been demonstrated in diabetes. The present study aimed at investigating their potential effects in obesity.Materials and methods NMRI male mice (n = 48) were ...
Fatemeh Jalalvand +4 more
doaj +1 more source
Results in ChemistryThis study presents the first evaluation of diverse iminosugars as inhibitors of a prokaryotic GH78 α-l-rhamnosidase. The pyrrolidine derivatives acted as enzyme competitive inhibitors.
Vladimír Puchart +2 more
doaj +1 more source
CHIMIA, 2001 This essay describes an approach facing some of the challenges of glycoscience, concentrating on the relation between structure and reactivity. This has resulted in new methods, precursors of carbohydrate-derived reactive intermediates, analysis
Andrea Vaselia
doaj
A formal total synthesis of deoxynojirimycin from D-glucitol
Journal of the Brazilian Chemical Society, 2003 This report deals with the formal synthesis of deoxynojirimycin using D-glucitol as an inexpensive starting material. Through a sequence of several selective protection/deprotection and nucleophilic substitution reactions, many isopropylidene derivatives
Braga Raquel M., Kato Lucilia
doaj
N-Alkyl Isofagomine Lactams: Synthesis, Glycosidase Inhibition, and Antimicrobial Assessments [PDF]
A series of six N-alkyl isofagomine lactam derivatives were synthesized over ten steps from D-arabinose. The compounds were evaluated as glycosidase inhibitors.
Sydnes, Magne O. +9 more
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Total Synthesis of a Lactam Glycosidase Inhibitor Precursor
, 2008 A total synthesis of an α,β-unsaturated γ-lactam is presented. This heterocycle is a precursor to a glycosidase inhibitor. Glycosidases function in the breakage of complex carbohydrates, yielding smaller sugars for cellular metabolism.
Eliasen, Anders
core
Back to (non-)Basics: An Update on Neutral and Charge-Balanced Glycosidase Inhibitors
, 2018 Glycosidases have important anti-cancer, anti-viral and anti-diabetic properties. This review covers the literature in the past 15 years since our initial review in this journal on “neutral” glycosidase inhibitors lacking a basic nitrogen found in ...
Laura J. Mares +13 more
core +1 more source