Results 51 to 60 of about 16,712 (156)

Diabetic kidney disease. new clinical and therapeutic issues. Joint position statement of the Italian Diabetes Society and the Italian Society of Nephrology on "the natural history of diabetic kidney disease and treatment of hyperglycemia in patients with type 2 diabetes and impaired renal function" [PDF]

, 2019
Recent epidemiological studies have disclosed heterogeneity in diabetic kidney disease (DKD). In addition to the classical albuminuric phenotype, two new phenotypes have emerged, i.e., “nonalbuminuric renal impairment” and “progressive renal decline ...
Barutta, Federica, De Nicola, Luca, Di Paolo, Salvatore, Gesualdo, Loreto, Natali, Andrea, Penno, Giuseppe, Pugliese, Giuseppe, Reboldi, Gianpaolo   +7 more
core   +1 more source

Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors

Molecules, 2019
A series of simple C-alkyl pyrrolidines already known as cytotoxic inhibitors of ceramide glucosylation in melanoma cells can be converted into their corresponding 6-membered analogues by means of a simple ring expansion.
Cécile Baudoin-Dehoux, Tessa Castellan, Frédéric Rodriguez, Arnaud Rives, Fabien Stauffert, Virginie Garcia, Thierry Levade, Philippe Compain, Yves Génisson   +8 more
doaj   +1 more source

Structure and activity of the Streptococcus pyogenes family GH1 6-phospho β-glycosidase, Spy1599 [PDF]

, 2013
The group A streptococcus Streptococcus pyogenes is the causative agent of a wide spectrum of invasive infections, including necrotizing fasciitis, scarlet fever and toxic shock syndrome.
Aguilar-Moncayo, Ajdić, Cantarel, Collin, Conejo, Cowtan, Cowtan, Edward J. Taylor, Emsley, Evans, Fujita, Gideon J. Davies, Gregg, Harry Brumer, Henrissat, Henrissat, Hondorp, Jens M. Eklof, Jerome Dabin, Jin, Johan P. Turkenburg, Judith Stepper, Kabsch, Kietzman, Kori, Leslie, McNicholas, Murshudov, Padilla, Pancholi, Prachumporn Kongsaeree, Preeyanuch Thongpoo, Ryan, Ryan, Seshadri, Shelburne, Shelburne, Shelburne, Sheldon, Suck, Suits, Vagin, Wiesmann, Wiesmann, Winn, Winter, Wright, Zechel   +47 more
core   +1 more source

Regioselectivity in the Ring Opening of Epoxides for the Synthesis of Aminocyclitols from D-(-)-Quinic Acid

Molecules, 2012
Efficient syntheses of four aminocyclitols are reported. Each synthesis is accomplished in eight steps starting from D-(-)-quinic acid. The key step involves a highly regioselective ring opening of epoxides by sodium azide.
Shu-Yu Yang, Tzenge-Lien Shih
doaj   +1 more source

Five-membered iminocyclitol a-glucosidase inhibitors: Synthetic,biological screening and in silico studies [PDF]

, 2013
The design and synthesis of a small library of pyrrolidine iminocyclitol inhibitors with a structural similarity to 1,4-dideoxy-1,4-imino-D-arabitol (DAB-1) is reported.
Burke, A J, Caldeira, A Teresa, Cardote, T, Carreiro, E, Fernandes, L, Guedes, R, Guerreiro, L, Moreira, R   +7 more
core   +1 more source

Evaluation of biochemical and histological indices of the pulp intactix teeth in the experimental conditions pulphyperthermia

Кубанский научный медицинский вестник, 2014
The article presents the results of experimental studies on the activity of acid lysosomal field of glycosidase inhibition (β-glucuronidase, β-glucosidase and β-N-acetylglucosaminidase) and their influence on the function of cells of the pulp in the ...
A. G. Sirak, I. M. Bykov, S. C. Sirak, A. C. Arutyunov, L. A. Parazyan, V. L. Popkov   +5 more
doaj  

Comparative genomic analysis of azasugar biosynthesis

AMB Express, 2021
Azasugars are monosaccharide analogs in which the ring oxygen is replaced with a nitrogen atom. These well-known glycosidase inhibitors are of interest as therapeutics, yet several aspects of azasugars remain unknown including their distribution ...
Hailey E. Beal, Nicole A. Horenstein
doaj   +1 more source

Novel Antioxidants and α-Glycosidase and Protein Tyrosine Phosphatase 1B Inhibitors from an Endophytic Fungus Penicillium brefeldianum F4a

Journal of Fungi, 2021
Oxidative stress plays a very important role in the progression of diabetes and its complications. A therapeutic agent that is both antidiabetic and antioxidant would be the preferred choice for the treatment of diabetes.
Yan Bai, Ping Yi, Songya Zhang, Jiangchun Hu, Huaqi Pan   +4 more
doaj   +1 more source

In vitro and in vivo protective efficacies of antibodies that neutralize the RNA N-glycosidase activity of Shiga toxin 2

BMC Immunology, 2010
Backgound Shiga toxin 2 (Stx2), one of two Stx liberated by Stx-producing Escherichia coli, is composed of an A subunit monomer and a B subunit pentamer, and is directly linked with hemolytic uremic syndrome in children. The pentameric B subunit binds to
Tzipori Saul, Lee Jongo, Singh Pradeep, Chapman-Bonofiglio Susan, Jeong Kwang-il, Sheoran Abhineet S   +5 more
doaj   +1 more source

Convergent, stereoselective syntheses of the glycosidase inhibitors broussonetines D and M [PDF]

, 2011
The first syntheses of the polyhydroxylated alkaloids (iminosugars) broussonetines D and M glycosidase inhibitors of the pyrrolidine class, have been performed in a convergent, stereocontrolled way from D-serine as the chiral starting material. A cross
Carda, Miguel, Falomir, Eva, Marco, J. Alberto, Murga, Juan, Ribés Vidal, Celia   +4 more
core   +2 more sources