A hydrophobic platform as a mechanistically relevant transition state stabilising factor appears to be present in the active centre of all glycoside hydrolases [PDF]
, 2003 An in silico survey of the −1 subsite of all known 3D-structures of O-glycoside hydrolases containing a suitably positioned ligand has led to the recognition – apparently without exceptions – of a transition state stabilising hydrophobic platform which ...
Wim Nerinckx +2 more
openalex +3 more sources
A shotgun approach to explore the bacterial diversity and a brief insight into the glycoside hydrolases of Samiti lake located in the Eastern Himalayas [PDF]
Journal of Genetic Engineering and Biotechnology, 2022 Background The Himalayas have always been an enigma and, being biodiversity hotspots, are considered extremely important from an ecological point of view. Recent advances in studies regarding high-altitude lakes have garnered relevant importance as these
Aditi Rai +3 more
doaj +2 more sources
GeneHunt for rapid domain-specific annotation of glycoside hydrolases. [PDF]
Sci Rep, 2019 The identification of glycoside hydrolases (GHs) for efficient polysaccharide deconstruction is essential for the development of biofuels. Here, we investigate the potential of sequential HMM-profile identification for the rapid and precise ...
Nguyen SN +6 more
europepmc +2 more sources
Genome-Wide Analysis of Whole Human Glycoside Hydrolases by Data-Driven Analysis in Silico. [PDF]
Int J Mol Sci, 2019 Glycans are involved in various metabolic processes via the functions of glycosyltransferases and glycoside hydrolases. Analysing the evolution of these enzymes is essential for improving the understanding of glycan metabolism and function.
Nakamura T +5 more
europepmc +2 more sources
Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases. [PDF]
J Biol Chem, 2019 During infection, the fungal pathogen Aspergillus fumigatus forms biofilms that enhance its resistance to antimicrobials and host defenses. An integral component of the biofilm matrix is galactosaminogalactan (GAG), a cationic polymer of α-1,4-linked ...
Le Mauff F +8 more
europepmc +2 more sources
Catalytic strategies of glycoside hydrolases [PDF]
, 2018 Glycoside hydrolases (GHs) are enzymes that catalyze the hydrolysis of the glycosidic bond between two carbohydrate residues or a carbohydrate unit linked to a non-carbohydrate aglycon unit. Despite years of research dedicated to GHs, there are still several mechanistic details, relevant for individual GH enzymes, that remain to be investigated.
Petersen, Luis
openaire +6 more sources
Transglycosylation by Glycoside Hydrolases - Production and modification of alkyl glycosides [PDF]
, 2015 To enable the transition to a green, bio-based economy, an extensive enzymatic toolbox competitive to traditional chemical procedures is needed. One strong area for enzymes is carbohydrate chemistry, due to the over-functionalized nature of carbohydrates, difficult to handle in traditional chemistry.
Lundemo, Pontus
openaire +4 more sources
Bioprospecting metagenomics of decaying wood: mining for new glycoside hydrolases [PDF]
Biotechnology for Biofuels, 2011 Background To efficiently deconstruct recalcitrant plant biomass to fermentable sugars in industrial processes, biocatalysts of higher performance and lower cost are required.
Li Luen-Luen +12 more
doaj +4 more sources
Targeted discovery of glycoside hydrolases from a switchgrass-adapted compost community. [PDF]
PLoS ONE, 2010 Development of cellulosic biofuels from non-food crops is currently an area of intense research interest. Tailoring depolymerizing enzymes to particular feedstocks and pretreatment conditions is one promising avenue of research in this area.
Martin Allgaier +10 more
doaj +3 more sources
Chitosanases from Family 46 of Glycoside Hydrolases: From Proteins to Phenotypes
Marine Drugs, 2015 Chitosanases, enzymes that catalyze the endo-hydrolysis of glycolytic links in chitosan, are the subject of numerous studies as biotechnological tools to generate low molecular weight chitosan (LMWC) or chitosan oligosaccharides (CHOS) from native, high
Pascal Viens +2 more
doaj +2 more sources