Results 21 to 30 of about 15,361 (204)

Increase of intestinal bacterial sialidase activity exacerbates acute colitis in mice

Frontiers in Molecular Biosciences, 2022
The availability of endogenous and dietary carbohydrates in the gastrointestinal tract influences the composition of the gut microbiota. Carbohydrate foraging requires the action of bacterially-encoded glycoside hydrolases, which release mono- and ...
Tobias Hasler, Leticia Tavares-Gomes, Sereina Gut, Meghna Swayambhu, Mario Gysi, Martin Hausmann, Natasha Arora, Thierry Hennet   +7 more
doaj   +1 more source

Two distinct catalytic pathways for GH43 xylanolytic enzymes unveiled by X-ray and QM/MM simulations

Nature Communications, 2021
Family 43 glycoside hydrolases (GH43) are involved in the breakdown of hemicellulose. Functional, structural and computational characterization of a GH43 enzyme, including a snapshot of an active Michaelis complex, reveal the hydrolysis mechanism and ...
Mariana A. B. Morais, Joan Coines, Mariane N. Domingues, Renan A. S. Pirolla, Celisa C. C. Tonoli, Camila R. Santos, Jessica B. L. Correa, Fabio C. Gozzo, Carme Rovira, Mario T. Murakami   +9 more
doaj   +1 more source

VdGAL4 Modulates Microsclerotium Formation, Conidial Morphology, and Germination To Promote Virulence in Verticillium dahliae

Microbiology Spectrum, 2023
Verticillium dahliae Kleb is a typical soilborne pathogen that can cause vascular wilt disease on more than 400 plants. Functional analysis of genes related to the growth and virulence is crucial to revealing the molecular mechanism of the pathogenicity ...
Yu Wen, Jinglong Zhou, Hongjie Feng, Wanqing Sun, Yalin Zhang, Lihong Zhao, Yong Cheng, Zili Feng, Heqin Zhu, Feng Wei   +9 more
doaj   +1 more source

A mutation map for human glycoside hydrolase genes [PDF]

Glycobiology, 2020
Abstract Glycoside hydrolases (GHs) are found in all domains of life, and at least 87 distinct genes encoding proteins related to GHs are found in the human genome. GHs serve diverse functions from digestion of dietary polysaccharides to breakdown of intracellular oligosaccharides, glycoproteins, proteoglycans and glycolipids. Congenital
Bernard Henrissat, Bernard Henrissat, Oluf Pedersen, Torben Hansen, Eric P. Bennett, Hans H. Wandall, Hassan Y. Naim, Mitali A. Tambe, Hudson H. Freeze, Birthe Gericke, Diab M Husein, Henrik Clausen, Lars Hansen   +12 more
openaire   +5 more sources

Glycoside hydrolase gene transcription by Alicyclobacillus acidocaldarius during growth on wheat arabinoxylan and monosaccharides: a proposed xylan hydrolysis mechanism

Biotechnology for Biofuels, 2018
Background Metabolism of carbon bound in wheat arabinoxylan (WAX) polysaccharides by bacteria requires a number of glycoside hydrolases active toward different bonds between sugars and other molecules.
Brady D. Lee, William A. Apel, Peter P. Sheridan, Linda C. DeVeaux   +3 more
doaj   +1 more source

Functional exploration of the glycoside hydrolase family GH113

PLOS ONE, 2022
β-Mannans are a heterogeneous group of polysaccharides with a common main chain of β-1,4-linked mannopyranoside residues. The cleavage of β-mannan chains is catalyzed by glycoside hydrolases called β-mannanases. In the CAZy database, β-mannanases are grouped by sequence similarity in families GH5, GH26, GH113 and GH134.
Couturier, Marie, Touvrey-Loiodice, Mélanie, Terrapon, Nicolas, Drula, Elodie, Buon, Laurine, Chirat, Christine, Henrissat, Bernard, Helbert, William   +7 more
openaire   +6 more sources

Annotation and comparative analysis of the glycoside hydrolase genes in Brachypodium distachyon

BMC Genomics, 2010
Background Glycoside hydrolases cleave the bond between a carbohydrate and another carbohydrate, a protein, lipid or other moiety. Genes encoding glycoside hydrolases are found in a wide range of organisms, from archea to animals, and are relatively ...
Wu Jiajie, Bragg Jennifer N, Tyler Ludmila, Yang Xiaohan, Tuskan Gerald A, Vogel John P   +5 more
doaj   +1 more source

Genomic and Transcriptomic Evidence for Carbohydrate Consumption Among Microorganisms in a Cold Seep Brine Pool

Frontiers in Microbiology, 2016
The detailed lifestyle of microorganisms in deep-sea brine environments remains largely unexplored. Using a carefully calibrated genome binning approach, we reconstructed partial to nearly-complete genomes of 51 microorganisms in biofilms from the Thuwal
Weipeng Zhang, Wei Ding, Bo Yang, Renmao Tian, Shuo Gu, Haiwei Luo, Pei-Yuan Qian   +6 more
doaj   +1 more source

Structural changes and molecular mechanism study on the inhibitory activity of epigallocatechin against α-glucosidase and α-amylase

Frontiers in Nutrition, 2022
In this study, the inhibition and mechanism of epigallocatechin (EGC) on two key glycoside hydrolases (α-glucosidase, α-amylase) were explored from the molecular structure level.
Ziyi Man, Yi Feng, Jibo Xiao, Hailong Yang, Xiangting Wu   +4 more
doaj   +1 more source

The evolutionary advantage of an aromatic clamp in plant family 3 glycoside exo-hydrolases

Nature Communications, 2022
Barley β-d-glucan glucohydrolase is a glycoside hydrolase family 3 (GH3) enzyme critical for growth and development. Here the authors carryout mutagenesis, structural analyses and multi-scale molecular dynamics to examine the binding and conformational ...
Sukanya Luang, Xavier Fernández-Luengo, Alba Nin-Hill, Victor A. Streltsov, Julian G. Schwerdt, Santiago Alonso-Gil, James R. Ketudat Cairns, Stéphanie Pradeau, Sébastien Fort, Jean-Didier Maréchal, Laura Masgrau, Carme Rovira, Maria Hrmova   +12 more
doaj   +1 more source