Results 41 to 50 of about 15,361 (204)

Glycoside Hydrolases for Extraction and Modification of Polyphenolic Antioxidants [PDF]

, 2013
Antioxidants are important molecules that are widely used by humans, both as dietary supplements and as additives to different types of products. In this chapter, we review how flavonoids, a class of polyphenolic antioxidants that are often found in glycosylated forms in many natural resources, can be extracted and modified using glycoside hydrolases ...
Gulshan Kazi, Zubaida, Khan, Sami, Kulkarni, Tejas, Pozzo, Tania, Nordberg Karlsson, Eva   +4 more
openaire   +4 more sources

Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action

Nature Communications, 2019
Sialidases are glycoside hydrolases that cleave sialosides. Here the authors define the 3-D structure, alone and in complex with products and inhibitors, of the CAZy family GH156 sialidase, EnvSia156, showing it displays a catalytical (β/α) 8-barrel ...
Pedro Bule, Léa Chuzel, Elena Blagova, Liang Wu, Melissa A. Gray, Bernard Henrissat, Erdmann Rapp, Carolyn R. Bertozzi, Christopher H. Taron, Gideon J. Davies   +9 more
doaj   +1 more source

Gut microbiome-derived hydrolases—an underrated target of natural product metabolism

Frontiers in Cellular and Infection Microbiology
In recent years, there has been increasing interest in studying gut microbiome-derived hydrolases in relation to oral drug metabolism, particularly focusing on natural product drugs.
Jiaxin He, Xiaofeng Liu, Junming Zhang, Rong Wang, Xinyuan Cao, Xinyuan Cao, Ge Liu   +6 more
doaj   +1 more source

In silico Approach for Unveiling the Glycoside Hydrolase Activities in Faecalibacterium prausnitzii Through a Systematic and Integrative Large-Scale Analysis

Frontiers in Microbiology, 2019
This work presents a novel in silico approach to the prediction and characterization of the glycolytic capacities of the beneficial intestinal bacterium Faecalibacterium prausnitzii. Available F.
Guillermo Blanco, Guillermo Blanco, Guillermo Blanco, Borja Sánchez, Florentino Fdez-Riverola, Florentino Fdez-Riverola, Florentino Fdez-Riverola, Abelardo Margolles, Anália Lourenço, Anália Lourenço, Anália Lourenço, Anália Lourenço   +11 more
doaj   +1 more source

Mechanism-Based Allylic Carbasugar Chlorides That Form Covalent Intermediates with α- and β-Galactosidases

Molecules
Glycoside hydrolases have been implicated in a wide range of human conditions including lysosomal storage diseases. Consequently, many researchers have directed their efforts towards identifying new classes of glycoside hydrolase inhibitors, both ...
Oluwafemi Akintola, Sandeep Bhosale, Andrew J. Bennet   +2 more
doaj   +1 more source

Exploring the hemicellulolytic properties and safety of Bacillus paralicheniformis as stepping stone in the use of new fibrolytic beneficial microbes

Scientific Reports, 2023
Bacillus strains from the Moroccan Coordinated Collections of Microorganisms (CCMM) were characterised and tested for fibrolytic function and safety properties that would be beneficial for maintaining intestinal homeostasis, and recommend beneficial ...
Serigne Inssa Ngom, Soufiane Maski, Bahia Rached, Taha Chouati, Lydie Oliveira Correia, Catherine Juste, Thierry Meylheuc, Bernard Henrissat, Elmostafa El Fahime, Mohamed Amar, Christel Béra-Maillet   +10 more
doaj   +1 more source

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

Nature Communications, 2020
Epithelial cells that line the gut secrete complex glycoproteins that form a mucus layer to protect the gut wall from enteric pathogens. Here, the authors provide a comprehensive characterisation of endo-acting glycoside hydrolases expressed by mucin ...
Lucy I. Crouch, Marcelo V. Liberato, Paulina A. Urbanowicz, Arnaud Baslé, Christopher A. Lamb, Christopher J. Stewart, Katie Cooke, Mary Doona, Stephanie Needham, Richard R. Brady, Janet E. Berrington, Katarina Madunic, Manfred Wuhrer, Peter Chater, Jeffery P. Pearson, Robert Glowacki, Eric C. Martens, Fuming Zhang, Robert J. Linhardt, Daniel I. R. Spencer, David N. Bolam   +20 more
doaj   +1 more source

Genomic Insights into the Fungal Lignocellulolytic Machinery of Flammulina rossica

Microorganisms, 2019
Next-generation sequencing (NGS) of the Flammulina rossica (wood-rotting basidiomycete) genome was performed to identify its carbohydrate-active enzymes (CAZymes).
Young-Jin Park, Chang-Soo Lee, Won-Sik Kong   +2 more
doaj   +1 more source

Disaccharide phosphorylases: Structure, catalytic mechanisms and directed evolution

Synthetic and Systems Biotechnology, 2021
Disaccharide phosphorylases (DSPs) are carbohydrate-active enzymes with outstanding potential for the biocatalytic conversion of common table sugar into products with attractive properties. They are modular enzymes that form active homo-oligomers. From a
Shangshang Sun, Chun You
doaj  

Purification, Molecular Cloning and Expression of Three Key Saponin Hydrolases from Trichoderma reesei, Trichoderma viride and Aspergillus fumigatus [PDF]

Nature Environment and Pollution Technology, 2019
Microbial transformation is an environment-friendly approach to produce diosgenin from natural plant tubers. However, improving the bioconversion efficiency of this process remains a challenge.
Jiamin Huang, Yangyang Wang, Linshan Fang, JiaojunJin, Suhui Ye, Wenjing Dun and Yuling Zhu
doaj