Results 41 to 50 of about 162,319 (334)

A mutation map for human glycoside hydrolase genes [PDF]

Glycobiology, 2020
Abstract Glycoside hydrolases (GHs) are found in all domains of life, and at least 87 distinct genes encoding proteins related to GHs are found in the human genome. GHs serve diverse functions from digestion of dietary polysaccharides to breakdown of intracellular oligosaccharides, glycoproteins, proteoglycans and glycolipids. Congenital
Bernard Henrissat, Bernard Henrissat, Oluf Pedersen, Torben Hansen, Eric P. Bennett, Hans H. Wandall, Hassan Y. Naim, Mitali A. Tambe, Hudson H. Freeze, Birthe Gericke, Diab M Husein, Henrik Clausen, Lars Hansen   +12 more
openaire   +7 more sources

Two distinct catalytic pathways for GH43 xylanolytic enzymes unveiled by X-ray and QM/MM simulations

Nature Communications, 2021
Family 43 glycoside hydrolases (GH43) are involved in the breakdown of hemicellulose. Functional, structural and computational characterization of a GH43 enzyme, including a snapshot of an active Michaelis complex, reveal the hydrolysis mechanism and ...
Mariana A. B. Morais, Joan Coines, Mariane N. Domingues, Renan A. S. Pirolla, Celisa C. C. Tonoli, Camila R. Santos, Jessica B. L. Correa, Fabio C. Gozzo, Carme Rovira, Mario T. Murakami   +9 more
doaj   +1 more source

VdGAL4 Modulates Microsclerotium Formation, Conidial Morphology, and Germination To Promote Virulence in Verticillium dahliae

Microbiology Spectrum, 2023
Verticillium dahliae Kleb is a typical soilborne pathogen that can cause vascular wilt disease on more than 400 plants. Functional analysis of genes related to the growth and virulence is crucial to revealing the molecular mechanism of the pathogenicity ...
Yu Wen, Jinglong Zhou, Hongjie Feng, Wanqing Sun, Yalin Zhang, Lihong Zhao, Yong Cheng, Zili Feng, Heqin Zhu, Feng Wei   +9 more
doaj   +1 more source

Glycoside hydrolase gene transcription by Alicyclobacillus acidocaldarius during growth on wheat arabinoxylan and monosaccharides: a proposed xylan hydrolysis mechanism

Biotechnology for Biofuels, 2018
Background Metabolism of carbon bound in wheat arabinoxylan (WAX) polysaccharides by bacteria requires a number of glycoside hydrolases active toward different bonds between sugars and other molecules.
Brady D. Lee, William A. Apel, Peter P. Sheridan, Linda C. DeVeaux   +3 more
doaj   +1 more source

Functional exploration of the glycoside hydrolase family GH113

PLOS ONE, 2022
β-Mannans are a heterogeneous group of polysaccharides with a common main chain of β-1,4-linked mannopyranoside residues. The cleavage of β-mannan chains is catalyzed by glycoside hydrolases called β-mannanases. In the CAZy database, β-mannanases are grouped by sequence similarity in families GH5, GH26, GH113 and GH134.
Marie Couturier, Mélanie Touvrey-Loiodice, Nicolas Terrapon, Elodie Drula, Laurine Buon, Christine Chirat, Bernard Henrissat, William Helbert   +7 more
openaire   +6 more sources

Exploration and Characterization of Novel Glycoside Hydrolases from the Whole Genome of Lactobacillus ginsenosidimutans and Enriched Production of Minor Ginsenoside Rg3(S) by a Recombinant Enzymatic Process

Biomolecules, 2020
Background: Several studies have reported that ginsenoside Rg3(S) is effective in treating metastatic diseases, obesity, and various cancers, however, its presence in white ginseng cannot be estimated, and only a limited amount is present in red ginseng.
M. Siddiqi, S. Srinivasan, H. Park, W. Im   +3 more
semanticscholar   +1 more source

Complementary Metagenomic Approaches Improve Reconstruction of Microbial Diversity in a Forest Soil. [PDF]

, 2020
Soil ecosystems harbor diverse microorganisms and yet remain only partially characterized as neither single-cell sequencing nor whole-community sequencing offers a complete picture of these complex communities.
Alteio, LV, Blanchard, JL, Bowers, RM, Eichorst, SA, Goudeau, D, Katz, LA, Malmstrom, RR, Rodriguez-Reillo, W, Ryan, E, Schulz, F, Seshadri, R, Varghese, N, Woyke, T   +12 more
core   +3 more sources

Identification of Carbohydrate Metabolism Genes in the Metagenome of a Marine Biofilm Community Shown to Be Dominated by Gammaproteobacteria and Bacteroidetes [PDF]

, 2010
Polysaccharides are an important source of organic carbon in the marine environment and degradation of the insoluble and globally abundant cellulose is a major component of the marine carbon cycle.
Connolly, John, Cox, Michael, Edwards, Clive, Edwards, Jennifer, Joint, Ian, McCarthy, Alan, McDonald, James, Smith, Darren   +7 more
core   +2 more sources

Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase. [PDF]

, 2014
BackgroundBacteroides spp. form a significant part of our gut microbiome and are well known for optimized metabolism of diverse polysaccharides. Initial analysis of the archetypal Bacteroides thetaiotaomicron genome identified 172 glycosyl hydrolases and
Axelrod, Herbert L, Chang, Yuanyuan, Eberhardt, Ruth Y, Godzik, Adam, Li, Zhanwen, Rigden, Daniel J, Sheydina, Anna, Zmasek, Christian C   +7 more
core   +2 more sources

The evolutionary advantage of an aromatic clamp in plant family 3 glycoside exo-hydrolases

Nature Communications, 2022
Barley β-d-glucan glucohydrolase is a glycoside hydrolase family 3 (GH3) enzyme critical for growth and development. Here the authors carryout mutagenesis, structural analyses and multi-scale molecular dynamics to examine the binding and conformational ...
Sukanya Luang, Xavier Fernández-Luengo, Alba Nin-Hill, Victor A. Streltsov, Julian G. Schwerdt, Santiago Alonso-Gil, James R. Ketudat Cairns, Stéphanie Pradeau, Sébastien Fort, Jean-Didier Maréchal, Laura Masgrau, Carme Rovira, Maria Hrmova   +12 more
doaj   +1 more source