Results 51 to 60 of about 162,319 (334)

Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of glycoside hydrolase. [PDF]

, 2014
BackgroundGut microbiome metagenomics has revealed many protein families and domains found largely or exclusively in that environment. Proteins containing the GxGYxYP domain are over-represented in the gut microbiota, and are found in Polysaccharide ...
Chang, Yuanyuan, Eberhardt, Ruth Y, Gilbert, Harry J, Godzik, Adam, Rigden, Daniel J, Xu, Qingping   +5 more
core   +2 more sources

Loop optimization of Trichoderma reesei endoglucanases for balancing the activity–stability trade‐off through cross‐strategy between machine learning and the B‐factor analysis

GCB Bioenergy, Volume 15, Issue 2, Page 128-142, February 2023., 2023
A cross‐strategy combination of machine learning and B‐factor analysis was used to predict beneficial amino acid substitution in endoglucanase (EG) loop optimization. Experimental validation showed single‐site mutated EG concomitantly improved enzymatic activity and thermal properties by 17.21%–18.06% and 49.85%–62.90%, respectively, compared with wild‐
Le Gao, Qi Guo, Ruinan Xu, Haofan Dong, Chichun Zhou, Zhuohang Yu, Zhaokun Zhang, Lixian Wang, Xiaoyi Chen, Xin Wu   +9 more
wiley   +1 more source

Structural changes and molecular mechanism study on the inhibitory activity of epigallocatechin against α-glucosidase and α-amylase

Frontiers in Nutrition, 2022
In this study, the inhibition and mechanism of epigallocatechin (EGC) on two key glycoside hydrolases (α-glucosidase, α-amylase) were explored from the molecular structure level.
Ziyi Man, Yi Feng, Jibo Xiao, Hailong Yang, Xiangting Wu   +4 more
doaj   +1 more source

How a Glycoside Hydrolase Recognizes a Helical Polyglucan [PDF]

Structure, 2017
Similarly to other biopolymers, linear polysaccharides can form double- or triple-helical structures. How enzymes recognize and manage this quaternary structure is an unresolved question. In this issue of Structure, Pluvinage et al. (2017) shed light on the structural complementarity between family GH81 glycoside hydrolase and the quaternary structure ...
Bernard Henrissat, Bernard Henrissat, Bernard Henrissat, Marie-Line Garron, Marie-Line Garron   +4 more
openaire   +6 more sources

Preparation of two glycoside hydrolases for use in micro-aqueous media [PDF]

, 2014
Enzymatic synthesis of alkyl glycosides using glycoside hydrolases is well studied, but has yet to reach industrial scale, primarily due to limited yields.
Adlercreutz, Patrick, Lundemo, Pontus, Nordberg Karlsson, Eva   +2 more
core   +2 more sources

Enzyme Similarity Networks [PDF]

arXiv, 2022
There is a crescent use of enzymes in multiple industries and sciences, ranging from materials and fuel synthesis to pharmaceutical and food production. Their applicability in this variety of fields depends not only on their biochemical function but also on their physicochemical properties.
arxiv  

Link between allosteric signal transduction and functional dynamics in a multi-subunit enzyme: S-adenosylhomocysteine hydrolase [PDF]

J. Am. Chem. Soc. (2011) vol. 133, 19807-19815, 2011
S-adenosylhomocysteine hydrolase (SAHH), a cellular enzyme that plays a key role in methylation reactions including those required for maturation of viral mRNA, is an important drug target in the discovery of antiviral agents. While targeting the active site is a straightforward strategy of enzyme inhibition, evidences of allosteric modulation of ...
arxiv   +1 more source

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of β-N-acetylglucosaminidases [PDF]

, 2007
The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of β-N-acetylglucosaminidases are described.
Adrian Scaffidi, Backvall, Bailey, Beer, Chen, Chretien, David J. Vocadlo, Davies, Davies, Dennis, Dong, Dorfmueller, Edward J. Taylor, Emsley, Esnouf, Fairweather, Gideon J. Davies, Horsch, Junge, Kappes, Keith A. Stubbs, Knapp, Kraulis, Legler, Lin, Liu, Liu, Macauley, Mark, Money, Murshudov, Namiki, Nicotra, Ogawa, Rana, Rao, Rebecca J. Dennis, Robert V. Stick, Salleh, Scaffidi, Shanmugasundaram, Shitara, Sigurskjold, Stubbs, Stubbs, Svensson, Tanaka, Terinek, Tews, Vocadlo   +49 more
core   +1 more source

Draft Genome Sequence of the Lignocellulose Decomposer Thermobifida fusca Strain TM51. [PDF]

, 2013
Here, we present the complete genome sequence of Thermobifida fusca strain TM51, which was isolated from the hot upper layer of a compost pile in Hungary. T.
Beki, Cantarel, Dhawan, Fekete, Hilge, Irwin, Jung, Kim, Kukolya, Lykidis, Moraïs, Posta, Wilson, Yang, Zhang   +14 more
core   +1 more source

Transcriptome Profiling-Based Analysis of Carbohydrate-Active Enzymes in Aspergillus terreus Involved in Plant Biomass Degradation

Frontiers in Bioengineering and Biotechnology, 2020
Given the global abundance of plant biomass residues, potential exists in biorefinery-based applications with lignocellulolytic fungi. Frequently isolated from agricultural cellulosic materials, Aspergillus terreus is a fungus efficient in secretion of ...
Camila L. Corrêa, Glaucia E. O. Midorikawa, Edivaldo Ximenes Ferreira Filho, Eliane Ferreira Noronha, Gabriel S. C. Alves, Roberto Coiti Togawa, Orzenil Bonfim Silva-Junior, Marcos Mota do Carmo Costa, Priscila Grynberg, Robert N. G. Miller   +9 more
doaj   +1 more source