Results 81 to 90 of about 28,465 (236)

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

Nature Communications, 2020
Epithelial cells that line the gut secrete complex glycoproteins that form a mucus layer to protect the gut wall from enteric pathogens. Here, the authors provide a comprehensive characterisation of endo-acting glycoside hydrolases expressed by mucin ...
Lucy I. Crouch, Marcelo V. Liberato, Paulina A. Urbanowicz, Arnaud Baslé, Christopher A. Lamb, Christopher J. Stewart, Katie Cooke, Mary Doona, Stephanie Needham, Richard R. Brady, Janet E. Berrington, Katarina Madunic, Manfred Wuhrer, Peter Chater, Jeffery P. Pearson, Robert Glowacki, Eric C. Martens, Fuming Zhang, Robert J. Linhardt, Daniel I. R. Spencer, David N. Bolam   +20 more
doaj   +1 more source

Advancements in Mass Spectrometry‐Based Glycomics in Food and Nutritional Science

Mass Spectrometry Reviews, EarlyView.
ABSTRACT This review highlights advancements in mass spectrometry (MS)‐based glycomics in food and nutritional science. Carbohydrates, which are vital for human health, exhibit complex structures, making their analysis challenging. MS has become an indispensable tool for elucidating the structures of carbohydrates, including glycans, through soft ...
JaeHui Song, HyunJi Lee, Youngshik Choe, Hyeyoung Lee   +3 more
wiley   +1 more source

Exploring the hemicellulolytic properties and safety of Bacillus paralicheniformis as stepping stone in the use of new fibrolytic beneficial microbes

Scientific Reports, 2023
Bacillus strains from the Moroccan Coordinated Collections of Microorganisms (CCMM) were characterised and tested for fibrolytic function and safety properties that would be beneficial for maintaining intestinal homeostasis, and recommend beneficial ...
Serigne Inssa Ngom, Soufiane Maski, Bahia Rached, Taha Chouati, Lydie Oliveira Correia, Catherine Juste, Thierry Meylheuc, Bernard Henrissat, Elmostafa El Fahime, Mohamed Amar, Christel Béra-Maillet   +10 more
doaj   +1 more source

Structural snapshots for mechanism-based inactivation of a glycoside hydrolase by cyclopropyl carbasugars [PDF]

, 2016
This work was supported by an NSERC Discovery Grant (AJB: #121348-2012), a Wellcome Trust Career Development Fellowship (TMG: grant 095828), a Wellcome Trust Institutional Strategic Support award (TMG and RJP), a MSFHR Career Investigator Award (RB), a ...
Bergeron-Brlek, Bergeron-Brlek, Bergeron-Brlek, Blakemore, Chakladar, Doyle, Friedrich, Grondal, Grondal, Lowry, Merceron, Michal, Schramm, Schramm, Schramm, Schwarz, Sinnott, Sinnott, Sinnott, Vocadlo, Vocadlo, Withers, Wolfenden, Wolfenden   +23 more
core   +1 more source

Novel applications of the tomato microbiome: Roles and considerations for agriculture, human health, and society

PLANTS, PEOPLE, PLANET, EarlyView.
Plants, like humans, have a microbiome that helps them grow, defend themselves against pathogens, acquire nutrients, and protect themselves against environmental stresses. The microbiome of tomatoes, a staple crop grown worldwide, could be utilized not only to reduce fertilizer and pesticide applications, but also to clean up harmful pollutants ...
Sean Lindert, Kathryn Kingsley, Peerapol Chiaranunt, James F. White   +3 more
wiley   +1 more source

Draft Genome Sequence of Botrytis cinerea BcDW1, Inoculum for Noble Rot of Grape Berries. [PDF]

, 2013
Botrytized wines are produced from grape berries infected by Botrytis cinerea under specific environmental conditions. Here, we report the draft genome sequence of B. cinerea BcDW1, a strain isolated from Sémillon grapes in Napa Valley in 1992 that ...
Allen, Greg, Blanco-Ulate, Barbara, Cantu, Dario, Powell, Ann LT   +3 more
core   +1 more source

In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini, Simona Saporiti, Crescenzo Coppa, Mara Rossi, Fabio Centola, Alessandro Arcovito   +5 more
wiley   +1 more source

NMR Line Shape Analysis of a Multi-state Ligand Binding Mechanism in Chitosanase [PDF]

, 2017
Chitosan interaction with chitosanase was examined through analysis of spectral line shapes in the NMR HSQC titration experiments. We established that the substrate, chitosan hexamer, binds to the enzyme through the three-state induced-fit mechanism with
Brzezinski, Ryszard, Fukamizo, Tamo, Furuita, Kyoko, Ghinet, Mariana G., Kojima, Chojiro, Kovrigin, Evgeni, Shah, Sneha, Shinya, Shoko   +7 more
core   +1 more source

Molecular and bioinformatics analyses reveal two differentially expressed intracellular GH1 β-glucosidases from the rare alkalophilic fungus Stachybotrys microspora [PDF]

, 2019
The present study reports the isolation and analysis of two novel GH1 β-glucosidases from the alkalophilic fungus Stachybotrys microspora, using PCR and Nested-PCR.
Abdeljalil, Salma, Borgi, Ines, Carvalho, Sandra, Gargouri, Ali, Jmal-Hammami, Lamia   +4 more
core   +2 more sources

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source