Results 1 to 10 of about 31,833 (220)

DANGO: An MS data annotation tool for glycolipidomics [PDF]

BBA Advances
Glycosphingolipids are essential components of all eukaryotic cells and play a major role in a broad range of cellular and biological processes, including growth, cell signaling, survival, differentiation, and disease.
Masaaki Matsubara, Mayumi Ishihara, Michael Tiemeyer, Kazuhiro Aoki, René Ranzinger   +4 more
doaj   +2 more sources

Specific Detection of Sialyltransferase ST3GAL3 Towards Lipid Acceptors by Liquid Chromatography Coupled with Tandem Mass Spectrometry Indicates Total Loss of Enzyme Activity in ST3GAL3 Pathogenic Variants [PDF]

Biomedicines
Background: Pathogenic ST3GAL3 variants cause neurological and cognitive impairment, defining a distinct congenital disorder of glycosylation (ST3GAL3-CDG). Nonetheless, limited enzyme characterization exists due to the lack of a non-radiochemical assay.
Sara Penati, Michele Dei Cas, Linda Montavoci, Anna Caretti, Marco Trinchera   +4 more
doaj   +2 more sources

Revealing the roles of glycosphingolipid metabolism pathway in the development of keloid: a conjoint analysis of single-cell and machine learning

Frontiers in Immunology, 2023
Keloid is a pathological scar formed by abnormal wound healing, characterized by the persistence of local inflammation and excessive collagen deposition, where the intensity of inflammation is positively correlated with the size of the scar formation ...
Binyu Song, Yu Zheng, Hao Chi, Yuhan Zhu, Zhiwei Cui, Lin Chen, Guo Chen, Botao Gao, Yichen Du, Zhou Yu, Baoqiang Song   +10 more
doaj   +1 more source

GOLM1 depletion modifies cellular sphingolipid metabolism and adversely affects cell growth

Journal of Lipid Research, 2022
Golgi membrane protein 1 (GOLM1) is a Golgi-resident type 2 transmembrane protein known to be overexpressed in several cancers, including hepatocellular carcinoma (HCC), as well as in viral infections.
Meghana Nagaraj, Marcus Höring, Maria A. Ahonen, Van Dien Nguyen, You Zhou, Helena Vihinen, Eija Jokitalo, Gerhard Liebisch, P.A. Nidhina Haridas, Vesa M. Olkkonen   +9 more
doaj   +1 more source

The Involvement of Lactosylceramide in Central Nervous System Inflammation Related to Neurodegenerative Disease

Frontiers in Aging Neuroscience, 2021
Neurodegenerative diseases are a class of slow-progressing terminal illnesses characterized by neuronal lesions, such as multiple sclerosis [MS, Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS)]. Their incidence
Wen Yu, Wen Yu, Jun Ying, Jun Ying, Xifeng Wang, Xing Liu, Xing Liu, Tiancheng Zhao, Sungtae Yoon, Qingcui Zheng, Qingcui Zheng, Yang Fang, Yang Fang, Danying Yang, Danying Yang, Fuzhou Hua, Fuzhou Hua   +16 more
doaj   +1 more source

Structure Elucidation of Calyxoside B, a Bipolar Sphingolipid from a Marine Sponge Cladocroce sp. through the Use of Beckmann Rearrangement

Marine Drugs, 2021
Marine sponges are an excellent source of biologically active secondary metabolites. We focus on deep-sea sponges for our discovery study. A marine sponge Cladocroce sp. exhibited cytotoxic activity in the bioactivity screening.
Kenji Sugawara, Hiroshi Watarai, Yuji Ise, Hisayoshi Yokose, Yasuhiro Morii, Nobuhiro Yamawaki, Shigeru Okada, Shigeki Matsunaga   +7 more
doaj   +1 more source

The Cellular and Chemical Biology of Endocytic Trafficking and Intracellular Delivery—The GL–Lect Hypothesis

Molecules, 2021
Lipid membranes are common to all forms of life. While being stable barriers that delimitate the cell as the fundamental organismal unit, biological membranes are highly dynamic by allowing for lateral diffusion, transbilayer passage via selective ...
Ludger Johannes
doaj   +1 more source

Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease

Frontiers in Neurology, 2021
Parkinson's disease (PD) is a movement disorder attributed to the loss of dopaminergic (DA) neurons mainly in the substantia nigra pars compacta. Motor symptoms include resting tremor, rigidity, and bradykinesias, while non-motor symptoms include ...
Albert Frank Magnusen, Shelby Loraine Hatton, Reena Rani, Manoj Kumar Pandey, Manoj Kumar Pandey   +4 more
doaj   +1 more source

Nanobody mediated inhibition of attachment of F18 fimbriae expressing Escherichia coli [PDF]

, 2014
Post-weaning diarrhea and edema disease caused by F18 fimbriated E. coli are important diseases in newly weaned piglets and lead to severe production losses in farming industry.
Coddens, Annelies, Cox, Eric, De Greve, Henri, De Kerpel, Maia, Moonens, Kristof, Pardon, Els, Remaut, Han   +6 more
core   +8 more sources

Effect of Glycosphingolipids on Osteoclastogenesis and Osteolytic Bone Diseases

Frontiers in Endocrinology, 2012
Alterations in glycosphingolipid production results in lysosomal storage disorders associated with neurodegenerative changes. In Gauchers disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in ...
Adel eErsek, Anastasios eKaradimitris, Nicole eHorwood   +2 more
doaj   +1 more source