Results 1 to 10 of about 35,445 (258)

Cytokine-driven glycosphingolipid metabolism modulates endoplasmic reticulum calcium homeostasis in primary human renal mesangial cells [PDF]

Frontiers in Immunology
IntroductionGlycosphingolipids (GSLs), including hexosylceramides (HexCers), lactosylceramides (LacCers), and gangliosides composed of one or more sugar residues attached to ceramide, are essential components of cell membranes.
Mariia Stefanenko, Mariia Stefanenko, Tessa M. Ortiz, Sandra G. Mungaray, Mykhailo Fedoriuk, Oleg Palygin, Stefano Berto, Drew Moore, Tamara K. Nowling   +8 more
doaj   +2 more sources

Revealing the roles of glycosphingolipid metabolism pathway in the development of keloid: a conjoint analysis of single-cell and machine learning

Frontiers in Immunology, 2023
Keloid is a pathological scar formed by abnormal wound healing, characterized by the persistence of local inflammation and excessive collagen deposition, where the intensity of inflammation is positively correlated with the size of the scar formation ...
Binyu Song, Yu Zheng, Hao Chi, Yuhan Zhu, Zhiwei Cui, Lin Chen, Guo Chen, Botao Gao, Yichen Du, Zhou Yu, Baoqiang Song   +10 more
doaj   +1 more source

GOLM1 depletion modifies cellular sphingolipid metabolism and adversely affects cell growth

Journal of Lipid Research, 2022
Golgi membrane protein 1 (GOLM1) is a Golgi-resident type 2 transmembrane protein known to be overexpressed in several cancers, including hepatocellular carcinoma (HCC), as well as in viral infections.
Meghana Nagaraj, Marcus Höring, Maria A. Ahonen, Van Dien Nguyen, You Zhou, Helena Vihinen, Eija Jokitalo, Gerhard Liebisch, P.A. Nidhina Haridas, Vesa M. Olkkonen   +9 more
doaj   +1 more source

Glycosphingolipid Levels in Urine Extracellular Vesicles Enhance Prediction of Therapeutic Response in Lupus Nephritis

Metabolites, 2022
The development of nephritis increases the risk of morbidity and mortality in systemic lupus erythematosus (SLE) patients. While standard induction therapies, such as mycophenolate mofetil (MMF) induce clinical remission (i.e., complete response) in ...
Brian Troyer, Jessalyn Rodgers, Bethany J. Wolf, James C. Oates, Richard R. Drake, Tamara K. Nowling   +5 more
doaj   +1 more source

The role of neuraminidase 1 (NEU1) in cytokine release by primary mouse mesangial cells and disease outcomes in murine lupus nephritis

Autoimmunity, 2021
The importance of altered glycosphingolipid (GSL) metabolism is increasingly gaining attention as a characteristic of multiple chronic kidney diseases. Previously, we reported elevated levels of GSLs and neuraminidase (NEU) enzyme activity/expression in ...
Jessalyn Rodgers, Kamala Sundararaj, Evelyn Bruner, Bethany Wolf, Tamara K. Nowling   +4 more
doaj   +1 more source

Dimeric Lectin Chimeras as Novel Candidates for Gb3-Mediated Transcytotic Drug Delivery through Cellular Barriers

Pharmaceutics, 2023
Receptor-mediated transcytosis is an elegant and promising strategy for drug delivery across biological barriers. Here, we describe a novel ligand–receptor pair based on a dimeric, engineered derivative of the Pseudomonas aeruginosa lectin LecA, here ...
Maokai Xu, Maria Antonova, Pavel Salavei, Katharina Illek, Ana Valeria Meléndez, Ramin Omidvar, Roland Thuenauer, Olga Makshakova, Winfried Römer   +8 more
doaj   +1 more source

Disialoganglioside GD2-Targeted Near-Infrared Photoimmunotherapy (NIR-PIT) in Tumors of Neuroectodermal Origin

Pharmaceutics, 2022
Disialoganglioside (GD2) is a subtype of glycolipids that is highly expressed in tumors of neuroectodermal origins, such as neuroblastoma and osteosarcoma.
Fuyuki F. Inagaki, Takuya Kato, Aki Furusawa, Ryuhei Okada, Hiroaki Wakiyama, Hideyuki Furumoto, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi   +8 more
doaj   +1 more source

The Involvement of Lactosylceramide in Central Nervous System Inflammation Related to Neurodegenerative Disease

Frontiers in Aging Neuroscience, 2021
Neurodegenerative diseases are a class of slow-progressing terminal illnesses characterized by neuronal lesions, such as multiple sclerosis [MS, Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS)]. Their incidence
Wen Yu, Wen Yu, Jun Ying, Jun Ying, Xifeng Wang, Xing Liu, Xing Liu, Tiancheng Zhao, Sungtae Yoon, Qingcui Zheng, Qingcui Zheng, Yang Fang, Yang Fang, Danying Yang, Danying Yang, Fuzhou Hua, Fuzhou Hua   +16 more
doaj   +1 more source

Structure Elucidation of Calyxoside B, a Bipolar Sphingolipid from a Marine Sponge Cladocroce sp. through the Use of Beckmann Rearrangement

Marine Drugs, 2021
Marine sponges are an excellent source of biologically active secondary metabolites. We focus on deep-sea sponges for our discovery study. A marine sponge Cladocroce sp. exhibited cytotoxic activity in the bioactivity screening.
Kenji Sugawara, Hiroshi Watarai, Yuji Ise, Hisayoshi Yokose, Yasuhiro Morii, Nobuhiro Yamawaki, Shigeru Okada, Shigeki Matsunaga   +7 more
doaj   +1 more source

Nanobody mediated inhibition of attachment of F18 fimbriae expressing Escherichia coli [PDF]

, 2014
Post-weaning diarrhea and edema disease caused by F18 fimbriated E. coli are important diseases in newly weaned piglets and lead to severe production losses in farming industry.
Coddens, Annelies, Cox, Eric, De Greve, Henri, De Kerpel, Maia, Moonens, Kristof, Pardon, Els, Remaut, Han   +6 more
core   +8 more sources