A hemolytic anti‐LKE associated with a rare LKE‐negative, “weak P” red blood cell phenotype: alloanti‐LKE and alloanti‐P recognize galactosylgloboside and monosialogalactosylgloboside (LKE) antigens [PDF]
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110583/1/trf12772 ...
Cooling, Laura +6 more
core +1 more source
ORMDL proteins in the endoplasmic reticulum (ER) negatively regulate serine palmitoyltransferase (SPT) activity in response to the rate of de novo sphingolipid synthesis. Disruption of ceramide homeostasis by myriocin or fumonisin B1 (FB1) appears to destabilize the ORMDL‐SPT complex, leading to ORMDL degradation as a feedback mechanism.
Michal Mrkacek +7 more
wiley +1 more source
Long-chain GM1 gangliosides alter transmembrane domain registration through interdigitation [PDF]
Extracellular and cytosolic leaflets in cellular membranes are distinctly different in lipid composition, yet they contribute together to signaling across the membranes.
Gabius, Hans-Joachim +5 more
core +4 more sources
Laurdan: Clarifying Photophysics and Advancing the Characterization of Extracellular Vesicles
Biophysical properties of extracellular vesicles (EVs) reflect their composition and membrane organization. We introduce a novel approach using time‐resolved emission spectra (TRES) phasor analysis of the polarity‐sensitive probe Laurdan to characterize membranes with complex compositions.
Petra Riegerová +8 more
wiley +1 more source
Although detergents are often essential in protocols, they are usually incompatible with further biochemical analysis. There are several methods for detergent removal, but the procedures are complicated or suffer from sample loss.
Yusuke Suzuki, Kazuya Kabayama
doaj +1 more source
The Microbiota Shapes Central Nervous System Myelination in Early Life
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch +13 more
wiley +1 more source
Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. [PDF]
Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.
Misto, Alessandra +3 more
core +1 more source
Dihydromyricetin Regulates PANoptosis to Protect Salmonella Typhimurium‐Infected Weaned Piglets
After DHM pretreatment, piglets were subjected to Salmonella infection. Serum and ileocecal samples from the piglets were collected for TUNEL assay, Western blotting analysis, and metabolomics analysis. The results collectively indicated that DHM could protect piglets from Salmonella infection.
Tingting Xiao +6 more
wiley +1 more source
Human glycolipid transfer protein (GLTP) genes: organization, transcriptional status and evolution [PDF]
Background Glycolipid transfer protein is the prototypical and founding member of the new GLTP superfamily distinguished by a novel conformational fold and glycolipid binding motif.
Xianqiong Zou +6 more
core +2 more sources
This study proposes the upcycling of oriental melon (Cucumis melo var. makuwa) stems, typically discarded as agricultural waste, into a bioactive extract with functional potential. CMSE ameliorates high‐fat‐diet‐induced obesity and fatty liver, contributing to the restoration of metabolic health by enhancing the expression of thermogenesis‐related ...
Myeong‐Jin Kim +10 more
wiley +1 more source

