Results 121 to 130 of about 26,122 (235)
Acta Ophthalmologica, Volume 104, Issue S293, Page S4-S35, October 2026.ENGLISH SUMMARY In developed countries, age‐related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. Understanding of its pathogenesis is limited and the number of patients is predicted to continue rising. AMD is classified into two main forms: dry and neovascular AMD (dAMD and nAMD, respectively).
Hanna Heloterä
wiley +1 more source
Protein O‐Glycosylation Shapes Lymphatic Endothelia and Lymph Node Macrophage Populations
The FASEB Journal, Volume 40, Issue 18, 30 September 2026.To study the functional roles of O‐glycans on lymphatic endothelia, we deleted Cosmc, the chaperone required for core‐1 O‐glycan synthesis. Loss of core‐1 O‐glycans entailed major changes in glycoprotein composition of lymphatic endothelial cells (LEC), including reduced podoplanin (Pdpn), CD44, and Lyve‐1, and increased ICAM‐1; reduced CD44 was caused
Jasmin Frey +11 more
wiley +1 more source
Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential
Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber +4 more
wiley +1 more source
Data for: Global Glycosphingolipid Analysis in Urine and Plasma of Female Fabry Disease Patients
Spreadsheets of measured glycosphingolipid isoforms in urine and fabry disease along with patient clinical and demograhic ...
Heywood, W
core +1 more source
Glucosylceramide flippases contribute to cellular glucosylceramide homeostasis
Journal of Lipid ResearchLipid transport is an essential cellular process with importance to human health, disease development, and therapeutic strategies. Type IV P-type ATPases (P4-ATPases) have been identified as membrane lipid flippases by utilizing nitrobenzoxadiazole (NBD)-
Natsuki Kita +7 more
doaj +1 more source
QCM-D studies of norovirus and glycosphingolipid interactions
, 2009 Susceptibility to norovirus infection has been linked to secretor status. Norovirus virus-like particles (VLPs; 0- 20 microg/mL) from the Norwalk (GI.1) and Dijon (GII.4) strains were assayed for binding to H type 1 and Lewis a pentaglycosylceramides ...
Dahlin, Andreas +3 more
core
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease MonitoringINTRODUCTION Whether circulating levels of sphingolipids are prospectively associated with cognitive decline and dementia risk is uncertain. METHODS We measured 14 sphingolipid species in plasma samples from 4488 participants (mean age 76.2 years; 40 ...
Kristine F. Moseholm +10 more
doaj +1 more source
DiagnosticsObjective: Metabolic reprogramming serves as a distinctive feature of cancer, impacting proliferation and metastasis, with aberrant glycosphingolipid expression playing a crucial role in malignancy.
Qinwen Ba, Xiong Wang, Hui Hu, Yanjun Lu
doaj +1 more source
The Glycosphingolipid Hydrolases in the Central Nervous System
, 2014 Glycosphingolipids are a large group of complex lipids particularly abundant in the outer layer of the neuronal plasma membranes. Qualitative and quantitative changes in glycosphingolipids have been reported along neuronal differentiation and aging ...
M. Aureli +7 more
core +1 more source
Editorial: Bioactive sphingolipids in health and disease
Frontiers in Molecular Biosciences, 2022 Mutay Aslan, Yesim Oztas, Liana C. Silva
doaj +1 more source