Results 111 to 120 of about 26,122 (235)

Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Metabolic dysregulation is a hallmark of Alzheimer's disease (AD), with numerous studies characterizing metabolic pathways associated with AD onset and progression. A limitation of these studies has been a focus on non‐Hispanic white participants.
Annalise Schweickart, Richa Batra, Kevin Huynh, Collette Blach, Alexandra Kueider‐Paisley, Joseph S. Reddy, David A. Bennett, Peter J. Meikle, Bin Zhang, Philip L. De Jager, Laura Heath, Jaclyn Beck, Jo Scanlan, Nicholas T. Seyfried, Dennis W. Dickson, Nilüfer Ertekin‐Taner, Alzheimer's Disease Metabolomics Consortium, Rima Kaddurah‐Daouk, Matthias Arnold, Jan Krumsiek   +19 more
wiley   +1 more source

Modifications of glycosphingolipid profile and synthesis in normal rat fibroblasts and in syngeneic neoplastic cells at different subculture stages

, 2000
Glycosphingolipids are plasma membrane macromolecules involved in diversified recognition functions on the cell surface resulting in modulation of cell adhesion and differentiation.
B. Berra, M. A. Meloni, P. Pippia, I. Colombo, Colombo, Irma, Meloni, Maria Antonia, Sottocornola, Elena, Moretti, Simona, E. Sottocornola, Pippia, Proto Gavino, S. Moretti, Berra, Bruno   +11 more
core   +1 more source

Acetylation‐like H2BK109Q attenuates acute brain injury and preserves axon‐myelin integrity after intracerebral hemorrhage

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
After intracerebral hemorrhage, reduced pan‐H2B acetylation is linked to acute brain injury and axon–myelin damage. The acetylation‐mimetic H2BK109Q substitution attenuates injury and preserves axon–myelin integrity. Regional Galc knockdown diminishes this protection, identifying GALC as a primary contributing effector. ABSTRACT Aims Axon–myelin damage
Sinan Jin, Meng Yang, Jincheng Meng, Ziyi Han, Yousef Rastegar‐Kashkooli, Pengtian Lu, Junmin Wang, Jian Wang, He Wu   +8 more
wiley   +1 more source

Graph attention network‐driven single‐cell omics analysis reveals how B4GALNT1‐mediated glycosylation remodelling of the ferroptosis–pyroptosis network promotes drug resistance in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Summary: B4GALNT1‐driven ganglioside/raft remodelling links ferroptosis suppression with restricted caspase‐1/GSDMD signalling during sorafenib resistance. Note: Schematic summary of the proposed B4GALNT1–ganglioside–lipid‐raft axis linking ferroptosis protection, restricted caspase‐1/GSDMD‐associated membrane permeabilisation, and sorafenib resistance.
Lihan Bie, Biao Xu, Haitao Shen, Shuwen Ren, Xiaoyang Yao, Zhouhong Xiang, Zheng Xu   +6 more
wiley   +1 more source

Glycolipids from sponges. 19. Terpioside from the marine sponge Terpios sp., the first glycosphingolipid having an L-fucofuranose unit

, 2008
The new diglycosylceramide terpioside has been isolated from the marine sponge Terpios sp. Terpioside is a diglycosylated glycosphingolipid which is the first example of a natural glycosphingolipid having an L-fucofuranose unit.
IMPERATORE, CONCETTA, Valeria Costantino, TETA, ROBERTA, Ernesto Fattorusso, Alfonso Mangoni, Roberta Teta, FATTORUSSO, ERNESTO, MANGONI, ALFONSO, COSTANTINO, VALERIA, Concetta Imperatore   +9 more
core   +1 more source

Discovery of Avian TCRVβ2+ T Cells Recognizing the Endogenous Ganglioside via a chCD1.1‐Dependent Pathway

European Journal of Immunology, Volume 56, Issue 10, October 2026.
We present the first report of chicken lipid‐reactive, NKT‐like TCRVβ2+ T cells that recognize the endogenous ganglioside GM3 presented by chCD1.1 on live antigen‐presenting cells. This activation induces a rapid cytokine response from avian lipid‐reactive T cells, offering a universal target for lipid‐adjuvanted poultry vaccines.
Nitin Kamble, Faisal R Anjum, Shahriar Behboudi   +2 more
wiley   +1 more source

Human Gb3/CD77 synthase: a glycosyltransferase at the crossroads of immunohematology, toxicology, and cancer research

Cellular & Molecular Biology Letters
Human Gb3/CD77 synthase (α1,4-galactosyltransferase, P1/Pk synthase, UDP-galactose: β-d-galactosyl-β1-R 4-α-d-galactosyltransferase, EC 2.4.1.228) forms Galα1 → 4Gal structures on glycosphingolipids and glycoproteins.
Katarzyna Szymczak-Kulus, Marcin Czerwinski, Radoslaw Kaczmarek   +2 more
doaj   +1 more source

Maturation‐Dependent Constraints in the Ability of Human Monocytes to Initiate Trained Immunity

MedComm, Volume 7, Issue 10, October 2026.
In premature infants, innate immune memory may serve as an important compensatory mechanism for the underdeveloped adaptive immune system. However, monocytes derived from prematurely born individuals display abnormal metabolic and insufficient transcriptomic responses to β‐glucan‐induced training.
Michael Eigenschink, Elsa Davogg, Manuel Pristner, David Seki, Marcus Arzmüller, Herbert Kiss, Alex Farr, Angelika Berger, David Berry, Benedikt Warth, Lukas Wisgrill   +10 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Specific Detection of Sialyltransferase ST3GAL3 Towards Lipid Acceptors by Liquid Chromatography Coupled with Tandem Mass Spectrometry Indicates Total Loss of Enzyme Activity in ST3GAL3 Pathogenic Variants

Biomedicines
Background: Pathogenic ST3GAL3 variants cause neurological and cognitive impairment, defining a distinct congenital disorder of glycosylation (ST3GAL3-CDG). Nonetheless, limited enzyme characterization exists due to the lack of a non-radiochemical assay.
Sara Penati, Michele Dei Cas, Linda Montavoci, Anna Caretti, Marco Trinchera   +4 more
doaj   +1 more source