Results 101 to 110 of about 26,122 (235)

Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain

Journal of Lipid Research, 2012
Synthesis inhibition is the basis for the treatment of type 1 Gaucher disease by the glucosylceramide synthase (GCS) inhibitor eliglustat tartrate. However, the extended use of eliglustat and related compounds for the treatment of glycosphingolipid ...
Scott D. Larsen, Michael W. Wilson, Akira Abe, Liming Shu, Christopher H. George, Paul Kirchhoff, H. D. Hollis Showalter, Jianming Xiang, Richard F. Keep, James A. Shayman   +9 more
doaj   +1 more source

Increased CSF sulfatide levels and serum glycosphingolipid antibody levels in healthy siblings of multiple sclerosis patients

, 2013
A proportion of healthy siblings of multiple sclerosis (MS) patients have an oligodonal immunological reaction in their cerebrospinal fluid (CSF) termed the "MS oligoclonal trait".
Nilsson, Staffan, Lekman, Annika,, Haghighi, Sara, Blomqvist, Maria K., Haghighi, Sara,, Andersen, Oluf,, Lekman, Annika, Nilsson, Staffan,, Andersen, Oluf, Blomqvist, Maria K.,   +9 more
core   +1 more source

Inhibiting glycosphingolipids alleviates cardiac hypertrophy by reducing reactive oxygen species and restoring autophagic homeostasis

Frontiers in Pharmacology
IntroductionCardiac hypertrophy is a compensatory stress response produced by a variety of factors, and pathologic hypertrophy can lead to irreversible, severe cardiac disease.
Chunxin Jiang, Menglei Tan, Lunmeng Lai, Yanping Wang, Zijun Chen, Qing Xie, Yunsen Li   +6 more
doaj   +1 more source

Thematic Review Series: Sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a*

Journal of Lipid Research, 2008
Gangliosides are sialic acid-containing glycosphingolipids that have long been associated with tumor malignancy and metastasis. Mounting evidence suggests that gangliosides also modulate tumor angiogenesis.
Purna Mukherjee, Anthony C. Faber, Laura M. Shelton, Rena C. Baek, Thomas C. Chiles, Thomas N. Seyfried   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, Volume 600, Issue 19, Page 2961-2971, October 2026.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Glycosphingolipid Disorders of the Brain

, 2008
Glycosphingolipids, comprising a ceramide lipid backbone linked to one/more saccharides, are particularly abundant on the outer leaflet of the eukaryotic plasma membrane and play a role in a wide variety of essential cellular processes. Biosynthesis and subsequently degradation of these lipids is tightly regulated via the involvement of numerous ...
Boomkamp, S, Butters, T
openaire   +2 more sources

New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases.

, 2003
Glycosphingolipid lysosomal storage diseases are a small but challenging group of human disorders to treat. Although these appear to be monogenic disorders where the catalytic activity of enzymes in glycosphingolipid catabolism is impaired, the ...
Platt, Frances, Platt, FM, Dwek, RA, Butters, TD   +3 more
core  

Adhesion analysis of breast cancer cell lines after glycosphingolipid biosynthesis inhibition.

, 2016
(A) Visualization of glycosphingolipid synthesis inhibition. In control condition, MDA-MB-231 expressed the glycosphingolipid GM1 (green) at the cell surface (left panel).
Philippe Delannoy (405518), Caroline Mysiorek (2557951), Aurore Drolez (2557954), Roméo Cecchelli (124873), Fabien Gosselet (2557948), Elodie Vandenhaute (2557960), Joy Burchell (2557957), Marie-Pierre Dehouck (579152), Sylvain Julien (405517)   +8 more
core   +1 more source

Glycosphingolipids as Receptors for Non-Enveloped Viruses

Viruses, 2010
Glycosphingolipids are ubiquitous molecules composed of a lipid and a carbohydrate moiety. Their main functions are as antigen/toxin receptors, in cell adhesion/recognition processes, or initiation/modulation of signal transduction pathways.
Stefan Taube, Mengxi Jiang, Christiane E. Wobus   +2 more
doaj   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source