Results 191 to 200 of about 26,122 (235)

Glycosphingolipids and insulin resistance

Progress in Lipid Research, 2009
Obesity is associated with an increased risk for insulin resistance, a state characterized by impaired responsiveness of liver, muscle and adipose tissue to insulin. One class of lipids involved in the development of insulin resistance are the (glyco)sphingolipids. Ceramide, the most simple sphingolipid, directly inhibits phosphorylation of the insulin
Mirjam, Langeveld, Johannes M F G, Aerts
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Soluble Adamantyl Glycosphingolipid Analogs as Probes of Glycosphingolipid Function

2006
Despite the extensive structural characterization of glycosphingolipids (GSLs), their functions in cell physiology and pathobiology remain elusive. This is largely owing to the fact that they are difficult to handle, being insoluble in aqueous media, and that no one gene alone determines their synthesis. The heterogeneity of the lipid moiety provides a
Clifford, Lingwood, Skanda, Sadacharan, Maan, Abul-Milh, Murugespillai, Mylvaganum, Marcus, Peter   +4 more
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Topology of glycosphingolipid degradation

Trends in Cell Biology, 1996
Glycosphingolipids (GSLs) form cell-type-specific patterns on the surface of eukaryotic cells. Degradation of plasma-membrane-derived GSLs in the lysosomes after internalization through the endocytic pathway is achieved through the concerted actions of hydrolysing enzymes and sphingolipid activator proteins.
K, Sandhoff, T, Kolter
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Glycosphingolipids in membrane architecture

Journal of Supramolecular Structure, 1977
AbstractAs part of a program to investigate the behavior and interactions of glycolipids in biological membranes we have synthesized spin‐labeled derivatives of 2 families of carbohydrate‐bearing ceramides (glycosphingolipids): simple neutral glycolipids and gangliosides.
F J, Sharom, C W, Grant
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Glycosphingolipids as toxin receptors

Seminars in Cell & Developmental Biology, 2004
A number of proteins produced by certain bacteria and plants are potently toxic to mammalian cells. This toxicity results from their ability to catalytically modify macromolecules that are required for essential cellular functions such as vesicular trafficking, cytoskeletal assembly, signalling or protein synthesis.
Daniel C, Smith, J Michael, Lord, Lynne M, Roberts, Ludger, Johannes   +3 more
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Biosynthesis and Catabolism of Glycosphingolipids

1982
Publisher Summary This chapter focuses on the advances made in the biosynthesis and catabolism of sugar chains in glycosphingolipids during the past two decades. Glycosphingolipids in animal cells have been shown to reflect tissue and species specificity.
Y T, Li, S C, Li
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The Degradation of Glycosphingolipids by Air

Journal of Biochemistry, 1997
Exposure of glycosphingolipids to air irreversibly destroys the integrity of these lipids within a few hours. It was established that among the natural constituents of air, ozone, at commonly observed daytime levels, is responsible for the observed degradation.
R, Jennemann, B L, Bauer, H, Wiegandt
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Glycosphingolipids of human plasma

Archives of Biochemistry and Biophysics, 1985
A number of glycosphingolipids, including 10 gangliosides, not previously identified in human plasma have been characterized. The plasma contains 2 micrograms of lipid-bound sialic acid/ml plasma and 54% of the gangliosides are monosialo, 30% disialo, 10% trisialo, and 6% tetrasialo.
S K, Kundu, I, Diego, S, Osovitz, D M, Marcus   +3 more
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Molecular arrangements in glycosphingolipids

Chemistry and Physics of Lipids, 1972
Abstract A number of homogeneous glycosphingolipids have been prepared and their structural behaviour studied in the solid state as well as in lipid-water systems and in surface films. Mainly X-ray diffraction techniques have been used in the phase analyses. A very complex phase pattern is usually found — e.g.
Sixten Abrahamsson, Irmin Pascher, Kåre Larsson, Karl-Anders Karlsson   +3 more
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Traveling for the glycosphingolipid path

Glycoconjugate Journal, 2000
Our studies on glycosphingolipids (GSLs) were initiated through isolation and structural characterization of lacto-series type 1 and 2 GSLs, and globo-series GSLs. Lacto-series structures included histo-blood group ABH and I/i antigens. Our subsequent studies were focused on GSL changes associated with: (i) ontogenic development and differentiation ...
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