Differential binding patterns of anti-sulfatide antibodies to glial membranes [PDF]
, 2018 Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may ...
Barrie, Jennifer A. +8 more
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Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells
Frontiers in Immunology, 2017 Invariant natural killer T (iNKT) cells represent a unique population of CD1d-restricted T lymphocytes expressing an invariant T cell receptor encoded by Vα14-Jα18 and Vα24-Jα18 gene segments in mice and humans, respectively.
Zoran V. Popovic +7 more
doaj +1 more source
Multiple Roles of Glycans in Hematological Malignancies
Frontiers in Oncology, 2018 The three types of blood cells (red blood cells for carrying oxygen, white blood cells for immune protection, and platelets for wound clotting) arise from hematopoietic stem/progenitor cells in the adult bone marrow, and function in physiological ...
Xingchen Pang +5 more
doaj +1 more source
Porcine iGb3s gene silencing provides minimal benefit for clinical xenotransplantation [PDF]
, 2016 Background The Galα(1,3)Gal epitope (α-GAL), created by α-1,3-glycosyltransferase-1 (GGTA1), is a major xenoantigen causing hyperacute rejection in pig-to-primate and pig-to-human xenotransplantation.
Butler, James R. +9 more
core +1 more source
Membrane dynamics and cell polarity: the role of sphingolipids
Journal of Lipid Research, 2003 In recent years, glycosphingolipids (GSLs) have attracted widespread attention due to the appreciation that this class of lipids has a major impact on biological life.
Dick Hoekstra +4 more
doaj +1 more source
Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease
Frontiers in Molecular Neuroscience, 2018 Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes related to their structural diversity, and based on this can be broadly classified into five categories; fatty acids, triacylglycerols (TAGs ...
Timothy J. Tracey +5 more
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Alterations in the properties of the cell membrane due to glycosphingolipid accumulation in a model of Gaucher disease [PDF]
, 2018 K
Batta, Gyula +7 more
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On the structure of cytolipin R, a ceramide tetrahexoside hapten from rat lymphosarcoma
Journal of Lipid Research, 1972 Cytolipin R, a ceramide tetrahexoside isolated from rat lymphosarcoma, was studied by sequential hydrolysis with specific glycosidases which revealed the anomeric configurations of the glycosidic bonds.
R. Laine +4 more
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Pathophysiological Role of Caveolae in Hypertension [PDF]
, 2019 Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1-4, EHD2, pacsin2, and dynamin 2.
Daumke, Oliver +4 more
core +2 more sources
Journal of Lipid Research, 2012 Endoglycoceramidase (EGCase) is a glycosidase capable of hydrolyzing the β -glycosidic linkage between the oligosaccharides and ceramides of glycosphingolipids (GSLs).
Yohei Ishibashi +7 more
doaj +1 more source