Results 31 to 40 of about 17,138 (226)

Sphingolipids: Effectors and Achilles Heals in Viral Infections?

Cells, 2021
As viruses are obligatory intracellular parasites, any step during their life cycle strictly depends on successful interaction with their particular host cells.
Sibylle Schneider-Schaulies, Fabian Schumacher, Dominik Wigger, Marie Schöl, Trushnal Waghmare, Jan Schlegel, Jürgen Seibel, Burkhard Kleuser   +7 more
doaj   +1 more source

Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice

Journal of Lipid Research, 2008
Glycosphingolipids (GSLs) have been implicated as potential atherogenic lipids. Studies in apolipoprotein E-null (apoE−/−) mice indicate that exacerbated tissue GSL accumulation resulting from α-galactosidase deficiency promotes atherosclerosis, whereas ...
Elias N. Glaros, Woojin S. Kim, Kerry-Anne Rye, James A. Shayman, Brett Garner   +4 more
doaj   +1 more source

Galectin-3 Interactions with Glycosphingolipids

, 2014
Galectins have essential roles in pathological states including cancer, inflammation, angiogenesis and microbial infections. Endogenous receptors include members of the lacto- and neolacto-series glycosphingolipids present on mammalian cells and contain ...
Yu, Xing, Blanchard, Helen, Bum-Erdene, Khuchtumur, Collins, Patrick, Bum-Erdene, KB, Collins, Patrick M   +5 more
core   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]

, 2008
Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Furukawa, K., Plomp, J.J., Willison, H.J., Willison, HJ, Verschuuren, JJ, Todorov, B, Furukawa, K, Jacobs, B.C., Zitman, FMP, Todorov, B., Zitman, F.M.P., Verschuuren, J.J., Plomp, JJ   +12 more
core   +1 more source

Porcine intestinal glycosphingolipids recognized by Brachyspira hyodysenteriae

, 2023
Swine dysentery caused by Brachyspira hyodysenteriae is a disease present worldwide with an important economic impact on the farming business, resulting in an increased use of antibiotics.
Zalem, Dani,, Teneberg, Susann,, Lindén, Sara K.,, Quintana-Hayashi, Macarena P,   +3 more
core   +1 more source

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, Accepted Article.
Background Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. Immunoglobulin G (IgG) from LN patients displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source

New Results On Glycosphingolipids

, 1992
The occurrence of glycoconjugates (glycosphingolipids, glycoproteins, and glycosyl phosphates) as integral constituents of membranes and cell walls has recently stimulated great research activities.
Escher, B, Schmidt, RR
core   +1 more source

Ganglioside GM2: a potential biomarker for cholangiocarcinoma

Journal of International Medical Research, 2020
Objective To investigate the expression of glycosphingolipids in serum and tissue from patients with cholangiocarcinoma compared with healthy controls. Methods Nanospray ionization-linear ion trap mass spectrometry (NSI-MS n ) was used to demonstrate the
Krajang Talabnin, Chutima Talabnin, Tadahiro Kumagai, Nuchanard Sutatum, Juthamas Khiaowichit, Chawaboon Dechsukhum, Mayumi Ishihara, Parastoo Azadi, Banchob Sripa   +8 more
doaj   +1 more source

Apprehending ganglioside diversity: a comprehensive methodological approach[S]

Journal of Lipid Research, 2015
Gangliosides (GGs) make a wide family of glycosphingolipids ubiquitously expressed in mammalian tissues and particularly abundant in the brain and nervous system.
ElodieA.Y. Masson, Estelle Sibille, Lucy Martine, Fanny Chaux-Picquet, Lionel Bretillon, Olivier Berdeaux   +5 more
doaj   +1 more source