Results 11 to 20 of about 14,058 (187)

Biochemical studies on sphingolipids of Artemia franciscana: novel neutral glycosphingolipids[S]

open access: yesJournal of Lipid Research, 2011
Neutral glycosphingolipids containing one to six sugars in their oligosaccharide chains have been isolated from cysts of the brine shrimp Artemia franciscana.
Hisao Kojima   +5 more
doaj   +1 more source

Erythrocyte and porcine intestinal glycosphingolipids recognized by F4 fimbriae of enterotoxigenic Escherichia coli.

open access: yesPLoS ONE, 2011
Enterotoxigenic F4-fimbriated Escherichia coli is associated with diarrheal disease in neonatal and postweaning pigs. The F4 fimbriae mediate attachment of the bacteria to the pig intestinal epithelium, enabling an efficient delivery of diarrhea-inducing
Annelies Coddens   +6 more
doaj   +1 more source

Ganglioside GM2: a potential biomarker for cholangiocarcinoma

open access: yesJournal of International Medical Research, 2020
Objective To investigate the expression of glycosphingolipids in serum and tissue from patients with cholangiocarcinoma compared with healthy controls. Methods Nanospray ionization-linear ion trap mass spectrometry (NSI-MS n ) was used to demonstrate the
Krajang Talabnin   +8 more
doaj   +1 more source

Glycosphingolipids within membrane contact sites influence their function as signaling hubs in neurodegenerative diseases

open access: yesFEBS Open Bio, 2023
Intracellular organelles carry out many of their functions by engaging in extensive interorganellar communication through specialized membrane contact sites (MCSs) formed where two organelles tether to each other or to the plasma membrane (PM) without ...
Jason Andrew Weesner   +3 more
doaj   +1 more source

Role of Globotriaosylceramide in Physiology and Pathology

open access: yesFrontiers in Molecular Biosciences, 2022
At first glance, the biological function of globoside (Gb) clusters appears to be that of glycosphingolipid (GSL) receptors for bacterial toxins that mediate host-pathogen interaction.
Ana Beatriz Celi   +6 more
doaj   +1 more source

Determination of long-chain base in glycosphingolipids with fluorescamine

open access: yesJournal of Lipid Research, 1974
A method is described for determining the longchain base content of glycosphingolipids after acid hydrolysis, using the new reagent fluorescamine. The reaction is sensitive and can be used to characterize or measure glycosphingolipids in quantities ...
Alemka Kisic, Maurice M. Rapport
doaj   +1 more source

Modulation of phospholipase A2 by electrostatic fields and dipole potential of glycosphingolipids in monolayers

open access: yesJournal of Lipid Research, 1999
Phospholipase A2 activity against mixed monolayers of dilauroylphosphatidic acid or dilauroylphosphatidylcholine with glycosphingolipids can be reversibly modulated by external constant electrostatic fields.
Bruno Maggio
doaj   +1 more source

Review and Proposal of Alternative Technologies for Comprehensive and Reliable Newborn Screening Using Paper Borne Urine Samples for Lysosomal Storage Disorders: Glycosphingolipid Disorders

open access: yesJournal of Inborn Errors of Metabolism and Screening, 2021
Few current methods are efficient to detect a high number of lysosomal storage disorders (LSDs) in newborn screening. Therefore, we propose a stepwise procedure that starts with the use of paper borne urine samples (Berry-Woolf specimen) for the ...
José Ramón Alonso-Fernández   +1 more
doaj   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

open access: yesAngewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster   +13 more
wiley   +2 more sources

Distribution of glycosphingolipids in the serum lipoproteins of normal human subjects and patients with hypo- and hyperlipidemias

open access: yesJournal of Lipid Research, 1976
Five glycosphingolipids (GSL), glucosylceramide, lactosylceramide, trihexosylceramide, globoside, and hematoside (GM3) were studied in serum from normal human subjects and patients with dyslipoproteinemia and found to be exclusively associated with the ...
G Dawson, A W Kruski, A M Scanu
doaj   +1 more source

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