Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy
Advanced Science, EarlyView.ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang +10 more
wiley +1 more source
How shall we use the proteomics toolbox for biomarker discovery? [PDF]
, 2007 Biomarker discovery for clinical purposes is one of the major areas in which proteomics is used. However, despite considerable effort, the successes have been relatively scarce.
Hochstrasser, Denis +2 more
core +5 more sources
Nonenzymatic glycosylation of human serum albumin alters its conformation and function.
Journal of Biological Chemistry, 1984 Approximately 10% of the albumin in normal human serum is modified by nonenzymatic glycosylation, primarily at the epsilon-amino group of lysine residue 525. Incubation of albumin with glucose under physiological conditions in vitro resulted in glycosylation of the same residue.
N, Shaklai, R L, Garlick, H F, Bunn
openaire +2 more sources
Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles
Advanced NanoBiomed Research, EarlyView.This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley +1 more source
Application Value of Serum Metabolic Markers for Cognitive Prediction in Elderly Epilepsy
Neuropsychiatric Disease and Treatment, 2022 Hong Wei,1 Dandan Liu,1,2 Leiyu Geng,1 Yun Liu,1 Huiqin Wang,1 Fuling Yan1 1Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, People’s Republic of China; 2Department of Neurology, The People’s ...
Wei H +5 more
doaj
Topographical mapping of epitopes on the glycoproteins of murine hepatitis virus-4 (strain JHM): correlation with biological activities. [PDF]
, 1984 Monoclonal hybridoma antibodies (MAb) of defined polypeptide specificity and biological activity were used in a competition binding assay to identify antibody binding sites (epitopes) on the glycoproteins of murine hepatitis virus-4 strain JHM (MHV-4 ...
Buchmeier, MJ +3 more
core
Matrix metalloproteinases-2,-3,-7,-9 and-10, but not MMP-11, are differentially expressed in normal, benign tumorigenic and malignant human keratinocyte cell lines [PDF]
, 2000 In order to investigate the correlations between constitutive proteinase expression and the degree of tumorigenicity of cancer cells we have studied a model system of three keratinocyte cell lines.
Bachmeier, B. E. +4 more
core +1 more source
cDNA Cloning Demonstrates the Expression of Pregnancy-Specific Glycoprotein Genes, a Subgroup of the Carcinoembryonic Antigen Gene Family, in Fetal Liver [PDF]
, 1989 The pregnancy-specific glycoprotein (PSG) genes constitute a subgroup of the carcinoembryonic antigen (CEA) gene family. Here we report the cloning of four cDNAs coding for different members of the PSG family from a human fetal liver cDNA library.
Thompson, John A. +2 more
core +1 more source
Measurement of Non-Enzymatic Glycosylated Serum Proteins (GSP) by Improved Thiobarbitoric Acid Assay
پزشکی بالینی ابن سینا, 1999 Several classes of protein may undergo non-enzymetic addition of glucose derived product. Hemoglobin was the first protein shown to be modified. Subsequent studies have demonstrated a similar effect of glucose on lens crystalline, collagen, erythrocyte ...
Iraj Khodadadi, Mahin Zahraei
doaj
The role of interleukin-19 in diabetic nephropathy
The Egyptian Journal of Internal Medicine, 2019 Background Proinflammatory cytokines play an important role in the establishment of arteriolosclerosis and kidney injury. Inflammatory cytokines are involved in the development of microvascular diabetic complications, including diabetic nephropathy (DN).
Khaled A Elhefnawy +2 more
doaj +1 more source